(Q40571639)

English

ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder

scientific article published on November 2003

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Europe PubMed Central

PubMed publication ID

21 September 2017

ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder (English)

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Europe PubMed Central

PubMed publication ID

21 September 2017

blood–brain barrier

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8

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Manfred Uhr

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Europe PubMed Central

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21 September 2017

Florian Holsboer

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Florian Holsboer

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21 September 2017

Elisabeth Binder

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Elisabeth B Binder

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Europe PubMed Central

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21 September 2017

Rainer Landgraf

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Rainer Landgraf

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21 September 2017

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Marianne B Müller

1

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Europe PubMed Central

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21 September 2017

Martin E Keck

2

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21 September 2017

Adelheid E Kresse

4

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21 September 2017

Thomas P Hagemeyer

5

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21 September 2017

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publication date

1 November 2003

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21 September 2017

Neuropsychopharmacology

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21 September 2017

28

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21 September 2017

11

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21 September 2017

1991-1999

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21 September 2017

Corticotropin releasing hormone, receptor regulation and the stress response.

1 reference

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Endocrine profile and neuroendocrine challenge tests in transgenic mice expressing antisense RNA against the glucocorticoid receptor

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Corticosteroids and cognition

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Neurobiology of the stress response early in life: evolution of a concept and the role of corticotropin releasing hormone

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The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

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Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities

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Enhanced cerebral uptake of receptor ligands by modulation of P-glycoprotein function in the blood-brain barrier

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Tissue-specific regulation of pituitary proopiomelanocortin gene transcription by corticotropin-releasing hormone, 3',5'-cyclic adenosine monophosphate, and glucocorticoids

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The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders

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Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

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The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety

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The corticosteroid receptor hypothesis of depression

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Corticosteroid actions in the hippocampus

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Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders

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Corticosteroids in relation to fear, anxiety and psychopathology.

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Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain after a single audiogenic seizure

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Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure

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Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress

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Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice.

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Genetic modification of corticosteroid receptor signalling: novel insights into pathophysiology and treatment strategies of human affective disorders

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Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus.

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Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment

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A novel prednisolone suppression test for the hypothalamic-pituitary-adrenal axis

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Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression

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Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

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P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

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Corticosterone modulation of ACTH secretogogue gene expression in the paraventricular nucleus

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Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-Glycoprotein gene disruption

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Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins

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Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption

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Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin

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In vivo model systems in P-glycoprotein-mediated multidrug resistance

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P-glycoprotein transports corticosterone and is photoaffinity-labeled by the steroid

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Corticosteroid receptor function is decreased in depressed patients

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Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids

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Long-term repetitive transcranial magnetic stimulation increases the expression of brain-derived neurotrophic factor and cholecystokinin mRNA, but not neuropeptide tyrosine mRNA in specific areas of rat brain

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Mrp1 multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells.

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Nucleotide sequence and expression of the mouse corticotropin-releasing hormone gene

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Identifiers

10.1038/SJ.NPP.1300257

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

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