(Q40575722)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15034210%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

title

Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo (English)

1 reference

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26 December 2019

7

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26 December 2019

Greg N. Brooke

3

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26 December 2019

author name string

D M Vigushin

1

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26 December 2019

N Mirsaidi

2

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26 December 2019

C Sun

4

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26 December 2019

P Pace

5

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26 December 2019

L Inman

6

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26 December 2019

R C Coombes

8

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26 December 2019

language of work or name

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1 January 2004

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26 December 2019

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26 December 2019

volume

21

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26 December 2019

issue

1

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26 December 2019

page(s)

21-30

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https://scigraph.springernature.com/pub.10.1385/mo:21:1:21

26 December 2019

exact match

0 references

cites work

Incidence of activating ras oncogene mutations associated with primary and metastatic human breast cancer

1 reference

12 December 2020

Mechanism of action of gliotoxin: elimination of activity by sulfhydryl compounds

1 reference

12 December 2020

Acute toxicity of gliotoxin in hamsters

1 reference

12 December 2020

Enzymatic modification of proteins with a geranylgeranyl isoprenoid

1 reference

12 December 2020

New colorimetric cytotoxicity assay for anticancer-drug screening

1 reference

12 December 2020

Effects of gliotoxin on Langerhans' cell function: contact hypersensitivity responses and skin graft survival

1 reference

12 December 2020

Antireverse transcriptase activity of gliotoxin analogs

1 reference

12 December 2020

The crystal structure of gliotoxin

1 reference

12 December 2020

Response of nitrosomethylurea-induced rat mammary tumor to endocrine therapy and comparison with clinical response

1 reference

12 December 2020

All ras proteins are polyisoprenylated but only some are palmitoylated

1 reference

12 December 2020

Gliotoxin inactivates alcohol dehydrogenase by either covalent modification or free radical damage mediated by redox cycling.

1 reference

12 December 2020

Protein prenylation: molecular mechanisms and functional consequences

1 reference

12 December 2020

Specific inhibition of influenza virus-induced ribonucleic acid polymerase by gliotoxin

1 reference

12 December 2020

Gliotoxin induces apoptosis in macrophages unrelated to its antiphagocytic properties.

1 reference

12 December 2020

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

1 reference

12 December 2020

Protein farnesyltransferase: measurement of enzymatic activity in 96-well format using TopCount microplate scintillation counting technology

1 reference

12 December 2020

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

1 reference

12 December 2020

Inhibition of farnesyl-protein transferase by gliotoxin and acetylgliotoxin

1 reference

12 December 2020

Immunosuppression in vitro by a metabolite of a human pathogenic fungus

1 reference

12 December 2020

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1 reference

12 December 2020

Assays for inhibitors of CAAX farnesyltransferase in vitro and in intact cells

1 reference

12 December 2020

Effects of an Antibiotic From Aspergillus fumigatus Fresenius on Tumor Cells in Vitro, and Its Possible Identity With Gliotoxin

1 reference

12 December 2020

Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.

1 reference

12 December 2020

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

1 reference

12 December 2020

Selective resistance of bone marrow-derived hemopoietic progenitor cells to gliotoxin.

1 reference

12 December 2020

In vivo immunosuppressive activity of gliotoxin, a metabolite produced by human pathogenic fungi

1 reference

12 December 2020

Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2

1 reference

12 December 2020

Amplified expression of p21 ras protein in hormone-dependent mammary carcinomas of humans and rodents

1 reference

12 December 2020

Gliotoxin Stimulates Ca2+ Release from Intact Rat Liver Mitochondria

1 reference

12 December 2020

DNA fragmentation induced in macrophages by gliotoxin does not require protein synthesis and is preceded by raised inositol triphosphate levels

1 reference

12 December 2020

Human lamin B contains a farnesylated cysteine residue

1 reference

12 December 2020

Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

1 reference

12 December 2020

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

1 reference

12 December 2020

Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice

1 reference

12 December 2020

1 reference

12 December 2020

Ras farnesyltransferase inhibitors suppress the phenotype resulting from an activated ras mutation in Caenorhabditis elegans

1 reference

12 December 2020

ras oncogenes in human cancer: a review

1 reference

12 December 2020

Apoptosis induced by gliotoxin is preceded by phosphorylation of histone H3 and enhanced sensitivity of chromatin to nuclease digestion

1 reference

12 December 2020

Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues

1 reference

12 December 2020

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1 reference

12 December 2020

Investigation of the potential use of immunosuppressive agent gliotoxin in organ transplantation

1 reference

12 December 2020

ras gene mutations are absent in NMU-induced mammary carcinomas from aging rats

1 reference

12 December 2020

Structural relationship of epipolythiodioxopiperazines and their immunomodulating activity

1 reference

12 December 2020

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

1 reference

12 December 2020

Evidence that gliotoxin enhances lymphocyte activation and induces apoptosis by effects on cyclic AMP levels

1 reference

12 December 2020

Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation

1 reference

12 December 2020

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

1 reference

12 December 2020

The chemistry and biology of the immunomodulating agent gliotoxin and related epipolythiodioxopiperazines

1 reference

12 December 2020

Cellular uptake and release of the immunomodulating fungal toxin gliotoxin

1 reference

12 December 2020

Comparison of potential markers of farnesyltransferase inhibition

1 reference

12 December 2020

The immunomodulating agent gliotoxin causes genomic DNA fragmentation.

1 reference

12 December 2020

The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB.

1 reference

12 December 2020

Manumycin and gliotoxin derivative KT7595 block Ras farnesylation and cell growth but do not disturb lamin farnesylation and localization in human tumour cells

1 reference

12 December 2020

Prognostic significance of the expression of a ras protein with a molecular weight of 21,000 by human breast cancer

1 reference

12 December 2020

Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus

1 reference

12 December 2020

Identifiers

DOI

10.1385/MO:21:1:21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15034210%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

26 December 2019

0 references

1 reference