(Q40588143)

English

Translocation of amyloid precursor protein C-terminal fragment(s) to the nucleus precedes neuronal death due to thiamine deficiency-induced mild impairment of oxidative metabolism

scientific article published on 4 March 2008

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Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

21 September 2017

Translocation of amyloid precursor protein C-terminal fragment(s) to the nucleus precedes neuronal death due to thiamine deficiency-induced mild impairment of oxidative metabolism (English)

1 reference

Europe PubMed Central

PMC publication ID

21 September 2017

author name string

Saravanan S Karuppagounder

1

1 reference

Europe PubMed Central

PMC publication ID

21 September 2017

Hui Xu

2

1 reference

Europe PubMed Central

PMC publication ID

21 September 2017

David Pechman

3

1 reference

Europe PubMed Central

PMC publication ID

21 September 2017

Lian H Chen

4

1 reference

Europe PubMed Central

PMC publication ID

21 September 2017

Lorraine A DeGiorgio

5

1 reference

Europe PubMed Central

PMC publication ID

21 September 2017

Gary E Gibson

6

1 reference

Europe PubMed Central

PMC publication ID

21 September 2017

publication date

4 March 2008

1 reference

Europe PubMed Central

PMC publication ID

21 September 2017

Neurochemical Research

1 reference

Europe PubMed Central

PMC publication ID

21 September 2017

33

1 reference

Europe PubMed Central

PMC publication ID

21 September 2017

7

1 reference

Europe PubMed Central

PMC publication ID

21 September 2017

1365-1372

1 reference

Europe PubMed Central

PMC publication ID

21 September 2017

https://scigraph.springernature.com/pub.10.1007/s11064-008-9594-z

0 references

Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

22 September 2017

Gene expression changes in thalamus and inferior colliculus associated with inflammation, cellular stress, metabolism and structural damage in thiamine deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

22 September 2017

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

22 September 2017

Pathophysiological roles of amyloidogenic carboxy-terminal fragments of the beta-amyloid precursor protein in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

22 September 2017

Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

22 September 2017

Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

22 September 2017

Actin in the nucleus: what form and what for?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

22 September 2017

Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

22 September 2017

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

22 September 2017

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

22 September 2017

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

22 September 2017

Proteolytic processing and cell biological functions of the amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

22 September 2017

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

22 September 2017

Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

22 September 2017

Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

22 September 2017

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

25 September 2017

Ionic effects of the Alzheimer's disease beta-amyloid precursor protein and its metabolic fragments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

25 September 2017

Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

17 June 2018

Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

17 June 2018

Thiamine deficiency alters APP but not presenilin-1 immunoreactivity in vulnerable brain regions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

17 June 2018

Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retina.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

20 August 2018

Pyrithiamine as a substrate for thiamine pyrophosphokinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

20 August 2018

Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

20 August 2018

CD40-CD40L interactions promote neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

20 August 2018

Tricarboxylic acid cycle enzymes following thiamine deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

20 August 2018

Increased brain endothelial nitric oxide synthase expression in thiamine deficiency: relationship to selective vulnerability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

20 August 2018

Reversal of thiamine deficiency-induced neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

20 August 2018

Amyloid precursor protein gene disruption attenuates degeneration of substantia nigra compacta neurons following axotomy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

20 August 2018

APP knockout attenuates microglial activation and enhances neuron survival in substantia nigra compacta after axotomy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

20 August 2018

Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

20 August 2018

Vascular factors are critical in selective neuronal loss in an animal model of impaired oxidative metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

20 August 2018

Oxidative stress is associated with region-specific neuronal death during thiamine deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

20 August 2018

Alpha-ketoglutarate dehydrogenase in Alzheimer brains bearing the APP670/671 mutation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2870991

20 August 2018

Neurotoxic APP C-terminal and β-amyloid domains colocalize in the nuclei of substantia nigra pars reticulata neurons undergoing delayed degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/18317926

12 December 2020

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10.1007/S11064-008-9594-Z

1 reference

Europe PubMed Central

PMC publication ID

21 September 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 September 2017

ResearchGate publication ID

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