(Q61463938)

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Neurotoxic APP C-terminal and β-amyloid domains colocalize in the nuclei of substantia nigra pars reticulata neurons undergoing delayed degeneration

scientific article published on 01 August 2000

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10960598%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Neurotoxic APP C-terminal and beta-amyloid domains colocalize in the nuclei of substantia nigra pars reticulata neurons undergoing delayed degeneration (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10960598%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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inferred from title

substantia nigra

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based on heuristic

inferred from title

4

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9 November 2019

5

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9 November 2019

author name string

L A DeGiorgio

1

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9 November 2019

N DeGiorgio

2

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9 November 2019

T A Milner

3

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9 November 2019

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1 August 2000

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9 November 2019

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9 November 2019

874

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9 November 2019

2

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9 November 2019

137-146

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9 November 2019

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

1 reference

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Human A beta-amyloid and amyloid precursor protein accumulates in rat brain cells after cultured human leptomeningeal fibroblast implants.

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Dizocilpine maleate, MK-801, but not 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline, NBQX, prevents transneuronal degeneration of nigral neurons after neurotoxic striatal-pallidal lesion

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Histological and temporal characteristics of nigral transneuronal degeneration after striatal injury.

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Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

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Expression of a carboxy-terminal region of the beta-amyloid precursor protein in a heterogeneous culture of neuroblastoma cells: evidence for altered processing and selective neurotoxicity

1 reference

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Overexpression of a C-terminal portion of the beta-amyloid precursor protein in mouse brains by transplantation of transformed neuronal cells

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Characterization of alternative routes for processing of the Alzheimer beta/A4-amyloid precursor protein. Differential effects of phorbol esters and chloroquine

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A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion

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Interleukin-1beta and glutamate activate the NF-kappaB/Rel binding site from the regulatory region of the amyloid precursor protein gene in primary neuronal cultures.

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Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro

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Intracortical Glutamate Perfusionin VivoInduces Cellular Alterations in Specific Protein Kinase C Isoforms and Amyloid Precursor Protein

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7 January 2021

Accumulation of apolipoprotein E and beta-amyloid-like protein in a trace of the hippocampal CA1 pyramidal cell layer after ischaemic delayed neuronal death.

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7 January 2021

Nuclear and cytoplasmic localization of the beta-amyloid peptide (1-43) in transfected 293 cells

1 reference

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7 January 2021

Neurotoxicity of a carboxyl-terminal fragment of the Alzheimer's amyloid precursor protein.

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7 January 2021

Apoptosis in substantia nigra following developmental striatal excitotoxic injury

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Membrane surface ruffling in cells that over-express Alzheimer amyloid beta/A4 C-terminal peptide.

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7 January 2021

Neuroprotective signal transduction: relevance to stroke

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Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease

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7 January 2021

Pathogenesis of decreased glucose turnover and oxidative phosphorylation in ischemic and trauma-induced dementia of the Alzheimer type

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7 January 2021

Hippocampal alpha2a-adrenergic receptors are located predominantly presynaptically but are also found postsynaptically and in selective astrocytes

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7 January 2021

Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.

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7 January 2021

Brain transplants of cells expressing the carboxyl-terminal fragment of the Alzheimer amyloid protein precursor cause specific neuropathology in vivo

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7 January 2021

Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein.

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7 January 2021

Immunocytochemical localization of amyloid precursor protein in rat brain

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7 January 2021

Prevention of transneuronal degeneration of neurons in the substantia nigra reticulata by ablation of the subthalamic nucleus

1 reference

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7 January 2021

Neurodegeneration and gliosis in transgenic mice overexpressing a carboxy-terminal fragment of Alzheimer amyloid-beta protein precursor

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7 January 2021

Normal and abnormal biology of the beta-amyloid precursor protein

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Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

1 reference

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7 January 2021

Behavioral and neuropathologic changes induced by central injection of carboxyl-terminal fragment of beta-amyloid precursor protein in mice.

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Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the beta-amyloid precursor protein

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Intraneuronal beta-amyloid immunoreactivity in the CNS.

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Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat

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Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

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Cytotoxic fragment of amyloid precursor protein accumulates in hippocampus after global forebrain ischemia.

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Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein.

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Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain

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Membrane currents induced in Xenopus oocytes by the C-terminal fragment of the beta-amyloid precursor protein.

1 reference

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based on heuristic

inferred from DOI database lookup

Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury

1 reference

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7 January 2021

based on heuristic

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Identifiers

10.1016/S0006-8993(00)02545-2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10960598%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10960598%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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