(Q40604578)

22 September 2017

title

Potent killing of paclitaxel- and doxorubicin-resistant breast cancer cells by calphostin C accompanied by cytoplasmic vacuolization (English)

1 reference

22 September 2017

Baoqing Guo

1

1 reference

22 September 2017

Stacey L Hembruff

2

1 reference

22 September 2017

David J Villeneuve

3

1 reference

22 September 2017

Angie F Kirwan

4

1 reference

22 September 2017

Amadeo M Parissenti

5

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22 September 2017

language of work or name

English

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publication date

1 November 2003

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Breast Cancer Research and Treatment

22 September 2017

published in

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22 September 2017

volume

82

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22 September 2017

issue

2

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22 September 2017

page(s)

125-141

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https://scigraph.springernature.com/pub.10.1023/b:brea.0000003969.21267.81

22 September 2017

exact match

0 references

cites work

Inhibitors of multidrug resistance to antitumor agents (MDR).

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

Human long-term bone marrow culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

Taxol suppresses dynamics of individual microtubules in living human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities

21 January 2018

2 references

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

21 January 2018

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Inhibition of transcription by adriamycin is a consequence of the loss of negative superhelicity in DNA mediated by topoisomerase II

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

Induction of multidrug resistance in MOLT-4 cells by anticancer agents is closely related to increased expression of functional P-glycoprotein and MDR1 mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Multidrug resistance in cancer: role of ATP-dependent transporters

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

The drug resistance-related protein LRP is the human major vault protein

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

P-glycoprotein--a mediator of multidrug resistance in tumour cells

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Multidrug resistance transporters and modulation

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Molecular and pharmacological strategies to overcome multidrug resistance

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Mechanisms of multidrug resistance in cancer treatment

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Integrins and extracellular matrix: a novel mechanism of multidrug resistance

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Deficient activation of the CD95 (APO-1/Fas) system in drug-resistant cells

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Inhibition of the membrane translocation and activation of protein kinase C, and potentiation of doxorubicin-induced apoptosis of hepatocellular carcinoma cells by tamoxifen

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Characterization of newly established human myeloid leukemia cell line (KF-19) and its drug resistant sublines

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Apoptosis and resistance to daunorubicin in human leukemic cells.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Down-regulation of apoptosis-related bcl-2 but not bcl-xL or bax proteins in multidrug-resistant MCF-7/Adr human breast cancer cells

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Modulation of multidrug resistance: at the threshold

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Clinical studies with modulators of multidrug resistance.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Cytotoxic effects of 27 anticancer drugs in HeLa and MDR1-overexpressing derivative cell lines

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Role of specific apoptotic pathways in the restoration of paclitaxel-induced apoptosis by valspodar in doxorubicin-resistant MCF-7 breast cancer cells

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Nonanthracycline containing docetaxel-based combinations in metastatic breast cancer

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Effect of Calphostin C (PKC inhibitor) on daunorubicin resistance in P388/ADR and HL60/AR cells: reversal of drug resistance possibly via P-glycoprotein

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

In vitro evaluation of calphostin C as a novel agent for photodynamic therapy of bladder cancer

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Differential modulation of P-glycoprotein transport by protein kinase inhibition.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Effects of protein kinase C modulators on multidrug resistance in human glioma cells

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Paclitaxel-induced apoptosis in MCF-7 breast-cancer cells

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Mechanism of action of taxol

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Differential spindle assembly checkpoint response in human lung adenocarcinoma cells.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Survival of docetaxel-resistant prostate cancer cells in vitro depends on phenotype alterations and continuity of drug exposure

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

A multistep model for paclitaxel-induced apoptosis in human breast cancer cell lines

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Apoptosis as a mechanism of cell death induced by different chemotherapeutic drugs in human leukemic T-lymphocytes

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Protein kinase C effectors bind to multidrug ABC transporters and inhibit their activity

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Morphological aspects of glucocorticoid-induced cell death in human lymphoblastoid cells

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Protein kinase C-epsilon associates with the Raf-1 kinase and induces the production of growth factors that stimulate Raf-1 activity.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Raf meets Ras: completing the framework of a signal transduction pathway

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Evidence that protein kinase Cepsilon mediates phorbol ester inhibition of calphostin C- and tumor necrosis factor-alpha-induced apoptosis in U937 histiocytic lymphoma cells

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas?

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Level of protein kinase C activity correlates directly with resistance to adriamycin in murine fibrosarcoma cells.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Orthotopic and ectopic organ environments differentially influence the sensitivity of murine colon carcinoma cells to doxorubicin and 5-fluorouracil.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Modulation of multidrug resistance in human ovarian cancer cell lines by inhibition of P-glycoprotein 170 and PKC isoenzymes with antisense oligonucleotides

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Apoptosis of human glioma cells in response to calphostin C, a specific protein kinase C inhibitor

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Calphostin C-mediated translocation and integration of Bax into mitochondria induces cytochrome c release before mitochondrial dysfunction.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Deoxycholic acid-induced apoptosis is switched to necrosis by bcl-2 and calphostin C

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

An alternative, nonapoptotic form of programmed cell death

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Differential phosphorylation of sites in the linker region of P-glycoprotein by protein kinase C isozymes alpha, betaI, betaII, gamma, delta, epsilon, eta, and zeta.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Correlation of protein kinase C translocation, P-glycoprotein phosphorylation and reduced drug accumulation in multidrug resistant human KB cells

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Protein kinase C-mediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoprotein

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Potent direct inhibition of mammalian phospholipase D isoenzymes by calphostin-c

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Calpain involvement in calphostin C-induced apoptosis

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

Protein kinase C inhibitor calphostin C prevents cytokine-induced angiogenesis in the rat

1 reference

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7 January 2021

Pharmacokinetic features and metabolism of calphostin C, a naturally occurring perylenequinone with antileukemic activity

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000003969.21267.81

7 January 2021

10.1023/B:BREA.0000003969.21267.81

Identifiers

DOI

1 reference

Dimensions Publication ID

22 September 2017

1046832067

0 references

1 reference