(Q40612687)

English

Divergent C-terminal transactivation domains of Rel/NF-kappa B proteins are critical determinants of their oncogenic potential in lymphocytes

scientific article published on February 2004

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scholarly article

1 reference

Europe PubMed Central

22 September 2017

Divergent C-terminal transactivation domains of Rel/NF-kappa B proteins are critical determinants of their oncogenic potential in lymphocytes (English)

1 reference

Europe PubMed Central

22 September 2017

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author name string

Yongjun Fan

1

1 reference

Europe PubMed Central

22 September 2017

Béatrice Rayet

2

1 reference

Europe PubMed Central

22 September 2017

Céline Gélinas

3

1 reference

Europe PubMed Central

22 September 2017

language of work or name

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publication date

1 February 2004

1 reference

Europe PubMed Central

22 September 2017

1 reference

Europe PubMed Central

22 September 2017

23

1 reference

Europe PubMed Central

22 September 2017

1030-1042

1 reference

Europe PubMed Central

22 September 2017

5

1 reference

Europe PubMed Central

22 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1207221

0 references

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells

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IkappaBalpha overexpression delays tumor formation in v-rel transgenic mice.

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Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells

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Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity

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Genetic analysis of NF- B/Rel transcription factors defines functional specificities

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

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NF-kappaB in cancer: from innocent bystander to major culprit

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relA over-expression reduces tumorigenicity and activates apoptosis in human cancer cells.

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Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells

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Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IkappaBalpha

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Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer

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Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

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Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.

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The v-rel oncogene encodes a kappa B enhancer binding protein that inhibits NF-kappa B function

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Control of apoptosis by Rel/NF-kappaB transcription factors

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Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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High-efficiency transformation of mammalian cells by plasmid DNA

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Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA

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A novel DNA recognition mode by the NF-kappa B p65 homodimer

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A new group of conserved coactivators that increase the specificity of AP-1 transcription factors

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Selective activation of NF-kappa B subunits in human breast cancer: potential roles for NF-kappa B2/p52 and for Bcl-3

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Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1 A resolution

1 reference

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Differential pp40I kappa B-beta inhibition of DNA binding by rel proteins

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High mutation rate of a spleen necrosis virus-based retrovirus vector

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New retrovirus helper cells with almost no nucleotide sequence homology to retrovirus vectors

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Immortalized embryonic mouse fibroblasts lacking the RelA subunit of transcription factor NF-kappaB have a malignantly transformed phenotype

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Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: analyses using tissue microarrays

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Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases

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Structure of NF-kappa B p50 homodimer bound to a kappa B site

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Rel/NF-kappa B/I kappa B signal transduction in the generation and treatment of human cancer

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Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel

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Malignant transformation of primary chicken spleen cells by human transcription factor c-Rel

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Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.

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X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2

1 reference

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c-rel activates but v-rel suppresses transcription from kappa B sites

1 reference

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Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2.

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Activation of NF-kappaB/Rel occurs early during neoplastic transformation of mammary cells

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Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells.

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AP-1 factors play an important role in transformation induced by the v-rel oncogene

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Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells.

1 reference

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The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein

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1 reference

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Differences in kappaB DNA-binding properties of v-Rel and c-Rel are the result of oncogenic mutations in three distinct functional regions of the Rel protein

1 reference

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1 reference

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1 reference

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1 reference

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Aberrant rel/nfkb genes and activity in human cancer

1 reference

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vRel is an inactive member of the Rel family of transcriptional activating proteins

1 reference

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Mouse mammary tumor virus c-rel transgenic mice develop mammary tumors

1 reference

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Loss of IkappaB alpha-mediated control over nuclear import and DNA binding enables oncogenic activation of c-Rel

1 reference

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1 reference

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1 reference

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Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

1 reference

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1 reference

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inferred from DOI database lookup

Deletion of either C-terminal transactivation subdomain enhances the in vitro transforming activity of human transcription factor REL in chicken spleen cells

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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10.1038/SJ.ONC.1207221

1 reference

Europe PubMed Central

22 September 2017

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1 reference

Europe PubMed Central

22 September 2017

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