(Q40617515)

22 September 2017

On the benzodiazepine binding pocket in GABAA receptors (English)

1 reference

22 September 2017

On the Benzodiazepine Binding Pocket in GABAA Receptors (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

31 March 2024

1 reference

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

31 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

31 March 2024

author name string

Dmytro Berezhnoy

1

1 reference

22 September 2017

Yves Nyfeler

2

1 reference

22 September 2017

Anne Gonthier

3

1 reference

22 September 2017

Hervé Schwob

4

1 reference

22 September 2017

Maurice Goeldner

5

1 reference

22 September 2017

Erwin Sigel

6

1 reference

22 September 2017

language of work or name

English

0 references

publication date

11 November 2003

1 reference

full work available at URL

22 September 2017

http://www.jbc.org/content/279/5/3160.full.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14612433

https://api.elsevier.com/content/article/PII:S0021925820751070?httpAccept=text/xml

31 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

https://api.elsevier.com/content/article/PII:S0021925820751070?httpAccept=text/plain

31 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

https://syndication.highwire.org/content/doi/10.1074/jbc.M311371200

31 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

Journal of Biological Chemistry

31 March 2024

published in

1 reference

22 September 2017

279

1 reference

22 September 2017

3160-3168

1 reference

22 September 2017

5

1 reference

22 September 2017

GABAA receptor channels

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

From ion currents to genomic analysis: recent advances in GABAA receptor research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

A novel class of GABAA receptor subunit in tissues of the reproductive system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Molecular and functional diversity of the expanding GABA-A receptor gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Which GABAA-receptor subtypes really occur in the brain?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

The effect of subunit composition of rat brain GABAA receptors on channel function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Stoichiometry of a ligand-gated ion channel determined by fluorescence energy transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Subunit arrangement of gamma-aminobutyric acid type A receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Forced subunit assembly in alpha1beta2gamma2 GABAA receptors. Insight into the absolute arrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

gamma-Aminobutyric acid type A receptor point mutation increases the affinity of compounds for the benzodiazepine site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

The major site of photoaffinity labeling of the gamma-aminobutyric acid type A receptor by [3H]flunitrazepam is histidine 102 of the alpha subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

A point mutation in the gamma2 subunit of gamma-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Subtle changes in residue 77 of the gamma subunit of alpha1beta2gamma2 GABAA receptors drastically alter the affinity for ligands of the benzodiazepine binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Key amino acids in the gamma subunit of the gamma-aminobutyric acidA receptor that determine ligand binding and modulation at the benzodiazepine site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Structural requirements for imidazobenzodiazepine binding to GABA(A) receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

GABA(A) receptor beta 2 Tyr97 and Leu99 line the GABA-binding site. Insights into mechanisms of agonist and antagonist actions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

The GABAA receptor alpha 1 subunit Pro174-Asp191 segment is involved in GABA binding and channel gating

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Anxiety over GABA(A) receptor structure relieved by AChBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Preservation and staining of myelinated nerve fibers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Interaction of non-competitive blockers within the gamma-aminobutyric acid type A chloride channel using chemically reactive probes as chemical sensors for cysteine mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Evaluation and biological properties of reactive ligands for the mapping of the glycine site on the N-methyl-D-aspartate (NMDA) receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Mapping the agonist binding site of the nicotinic acetylcholine receptor. Orientation requirements for activation by covalent agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Specific binding sites for alcohols and anesthetics on ligand-gated ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Structural Model of the N-Methyl-D-aspartate Receptor Glycine Site Probed by Site-directed Chemical Coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Identification of the binding sites of the SR49059 nonpeptide antagonist into the V1a vasopressin receptor using sulfydryl-reactive ligands and cysteine mutants as chemical sensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Cysteine mutants as chemical sensors for ligand-receptor interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

GABAA-receptor expressed from rat brain alpha- and beta-subunit cDNAs displays potentiation by benzodiazepine receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

High-efficiency transformation of mammalian cells by plasmid DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

The relative amount of cRNA coding for gamma2 subunits affects stimulation by benzodiazepines in GABA(A) receptors expressed in Xenopus oocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Properties of single sodium channels translated by Xenopus oocytes after injection with messenger ribonucleic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Electrophysiological evidence for the coexistence of alpha1 and alpha6 subunits in a single functional GABA(A) receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

m-Sulfonate benzene diazonium chloride: a powerful affinity label for the gamma-aminobutyric acid binding site from rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Identification of the bovine gamma-aminobutyric acid type A receptor alpha subunit residues photolabeled by the imidazobenzodiazepine [3H]Ro15-4513.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Comparative modeling of GABA(A) receptors: limits, insights, future developments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Selective antagonists of benzodiazepines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Amino acid residue 200 on the alpha1 subunit of GABA(A) receptors affects the interaction with selected benzodiazepine binding site ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Molecular determinants of recognition and activation at the cerebellar benzodiazepine receptor site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311371200

Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties [corrected; erratum to be published]

21 January 2018

6

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

31 March 2024

Pharmacological Reviews

9

50

291

Barnard

1998

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum.

31 March 2024

10

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

Stoichiometry of a recombinant GABAA receptor.

31 March 2024

16

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

Stoichiometry and assembly of a recombinant GABAA receptor subtype.

31 March 2024

17

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

31 March 2024

Pharmacological Reviews

21

47

181

Sieghart

1995

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

Residues at positions 206 and 209 of the alpha1 subunit of gamma-aminobutyric AcidA receptors influence affinities for benzodiazepine binding site ligands

31 March 2024

28

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

Two tyrosine residues on the alpha subunit are crucial for benzodiazepine binding and allosteric modulation of gamma-aminobutyric acidA receptors

31 March 2024

30

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

A (beta)-strand in the (gamma)2 subunit lines the benzodiazepine binding site of the GABA A receptor: structural rearrangements detected during channel gating.

31 March 2024

34

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

Point mutations affecting antagonist affinity and agonist dependent gating of GABAA receptor channels.

31 March 2024

35

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

Mapping the agonist binding site of the GABAA receptor: evidence for a beta-strand.

31 March 2024

39

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

Structure and dynamics of the GABA binding pocket: A narrowing cleft that constricts during activation.

31 March 2024

41

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

31 March 2024

Molecular Pharmacology

46

31

334

Borea

1987

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

31 March 2024

Molecular Pharmacology

47

36

589

Villar

1989

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

The benzodiazepine binding pocket of recombinant alpha1beta2gamma2 gamma-aminobutyric acidA receptors: relative orientation of ligands and amino acid side chains

31 March 2024

50

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

Photoaffinity labeling of the benzodiazepine binding site of alpha1beta3gamma2 gamma-aminobutyric acidA receptors with flunitrazepam identifies a subset of ligands that interact directly with His102 of the alpha subunit and predicts orientation of t

31 March 2024

51

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

Substituted-cysteine accessibility method

31 March 2024

52

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

Scanning mutagenesis identifies amino acid side chains in transmembrane domain 5 of the M(1) muscarinic receptor that participate in binding the acetyl methyl group of acetylcholine

31 March 2024

55

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

Functional characteristics and sites of gene expression of the alpha 1, beta 1, gamma 2-isoform of the rat GABAA receptor

31 March 2024

63

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

31 March 2024

Molecular Pharmacology

75

56

768

Dunn

1999

1 reference

https://api.crossref.org/works/10.1074/JBC.M311371200

31 March 2024

Identifiers

1 reference

22 September 2017

1 reference