(Q43662797)

English

A (beta)-strand in the (gamma)2 subunit lines the benzodiazepine binding site of the GABA A receptor: structural rearrangements detected during channel gating.

scientific article published in July 2001

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11438573%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

A (beta)-strand in the (gamma)2 subunit lines the benzodiazepine binding site of the GABA A receptor: structural rearrangements detected during channel gating (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11438573%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Jeremy Teissére

1

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J A Teissére

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11438573%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

author name string

C Czajkowski

2

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Europe PubMed Central

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9 November 2019

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publication date

1 July 2001

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11438573%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11438573%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

21

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11438573%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

14

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11438573%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

4977-4986

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11438573%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Enhancement of GABA binding by benzodiazepines and related anxiolytics

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The benzodiazepine binding pocket of recombinant alpha1beta2gamma2 gamma-aminobutyric acidA receptors: relative orientation of ligands and amino acid side chains

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subtle changes in residue 77 of the gamma subunit of alpha1beta2gamma2 GABAA receptors drastically alter the affinity for ligands of the benzodiazepine binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A point mutation in the gamma2 subunit of gamma-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two invariant tryptophans on the alpha1 subunit define domains necessary for GABA(A) receptor assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Empirical Predictions of Protein Conformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping the agonist binding site of the GABAA receptor: evidence for a beta-strand.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactivity of small thiolate anions and cysteine-25 in papain toward methyl methanethiosulfonate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photoaffinity labeling of the benzodiazepine binding site of alpha1beta3gamma2 gamma-aminobutyric acidA receptors with flunitrazepam identifies a subset of ligands that interact directly with His102 of the alpha subunit and predicts orientation of t

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Key amino acids in the gamma subunit of the gamma-aminobutyric acidA receptor that determine ligand binding and modulation at the benzodiazepine site.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benzodiazepines induce a conformational change in the region of the gamma-aminobutyric acid type A receptor alpha(1)-subunit M3 membrane-spanning segment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric receptors after 30 years

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The benzodiazepine binding site of GABAA receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular dissection of benzodiazepine binding and allosteric coupling using chimeric gamma-aminobutyric acidA receptor subunits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of external loop topology in the serotonin transporter by site-directed chemical labeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potassium currents expressed from Drosophila and mouse eag cDNAs in Xenopus oocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of benzodiazepine binding site residues in the gamma2 subunit of the gamma-aminobutyric acid(A) receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural requirements for ligand interactions at the benzodiazepine recognition site of the GABA(A) receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zn2+ inhibition of recombinant GABAA receptors: an allosteric, state-dependent mechanism determined by the gamma-subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substituted-cysteine accessibility method

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of transduction elements for benzodiazepine modulation of the GABA(A) receptor: three residues are required for allosteric coupling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and dynamics of the GABA binding pocket: A narrowing cleft that constricts during activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.21-14-04977.2001

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11438573%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11438573%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11438573%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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