(Q40630837)

English

Inhibition of Net HepG2 Cell Apolipoprotein B Secretion by the Citrus Flavonoid Naringenin Involves Activation of Phosphatidylinositol 3-Kinase, Independent of Insulin Receptor Substrate-1 Phosphorylation

scientific article published on October 1, 2003

In more languages

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Inhibition of Net HepG2 Cell Apolipoprotein B Secretion by the Citrus Flavonoid Naringenin Involves Activation of Phosphatidylinositol 3-Kinase, Independent of Insulin Receptor Substrate-1 Phosphorylation (English)

1 reference

10.2337/DIABETES.52.10.2554

https://api.crossref.org/works/10.2337/DIABETES.52.10.2554

15 March 2024

phosphorylation

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

0 references

internal medicine

1 reference

10.2337/DIABETES.52.10.2554

https://api.crossref.org/works/10.2337/DIABETES.52.10.2554

15 March 2024

author name string

Nica M. Borradaile

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14514640

15 March 2024

Linda E. de Dreu

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14514640

15 March 2024

Murray W. Huff

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14514640

15 March 2024

language of work or name

0 references

publication date

1 October 2003

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

full work available at URL

https://diabetesjournals.org/diabetes/article-pdf/52/10/2554/370191/db1003002554.pdf

Portable Document Format

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14514640

15 March 2024

https://journals.org/diabetes/diabetes/article-pdf/52/10/2554/370191/db1003002554.pdf

Portable Document Format

1 reference

10.2337/DIABETES.52.10.2554

https://api.crossref.org/works/10.2337/DIABETES.52.10.2554

15 March 2024

https://diabetesjournals.org/diabetes/article-pdf/52/10/2554/370191/db1003002554.pdf

Portable Document Format

1 reference

10.2337/DIABETES.52.10.2554

https://api.crossref.org/works/10.2337/DIABETES.52.10.2554

15 March 2024

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

52

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

2554-2561

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Dietary flavonoids: bioavailability, metabolic effects, and safety

2

1 reference

10.2337/DIABETES.52.10.2554

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Antihyperlipidemic effect of flavonoids from Prunus davidiana

3

1 reference

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Improvement of hyperglycemia and hyperlipemia in streptozotocin-diabetic rats by a methanolic extract of Prunus davidiana stems and its main component, prunin

4

1 reference

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Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A:cholesterol acyltransferase in rats

5

1 reference

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15 March 2024

Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy-3-methyl-glutaryl-CoA reductase and acyl CoA: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids

6

1 reference

10.2337/DIABETES.52.10.2554

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15 March 2024

Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits

8

1 reference

10.2337/DIABETES.52.10.2554

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15 March 2024

Regulation of HepG2 cell apolipoprotein B metabolism by the citrus flavanones hesperetin and naringenin

9

1 reference

10.2337/DIABETES.52.10.2554

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15 March 2024

Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins

10

1 reference

10.2337/DIABETES.52.10.2554

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The activity of microsomal triglyceride transfer protein is essential for accumulation of triglyceride within microsomes in McA-RH7777 cells. A unified model for the assembly of very low density lipoproteins

11

1 reference

10.2337/DIABETES.52.10.2554

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15 March 2024

Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation

12

1 reference

10.2337/DIABETES.52.10.2554

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15 March 2024

Hepatocyte apoB-containing lipoprotein secretion is decreased by the grapefruit flavonoid, naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulation

13

1 reference

10.2337/DIABETES.52.10.2554

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15 March 2024

Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly

14

1 reference

10.2337/DIABETES.52.10.2554

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15 March 2024

Inhibition of hepatocyte apoB secretion by naringenin: enhanced rapid intracellular degradation independent of reduced microsomal cholesteryl esters.

15

1 reference

10.2337/DIABETES.52.10.2554

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15 March 2024

The role of the LDL receptor in apolipoprotein B secretion

16

1 reference

10.2337/DIABETES.52.10.2554

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Regulation of low-density-lipoprotein-receptor mRNA by insulin in human hepatoma Hep G2 cells

18

1 reference

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Insulin signalling and the regulation of glucose and lipid metabolism

19

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Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes.

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.

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ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose

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1 reference

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The role of SREBP-1c in nutritional regulation of lipogenic enzyme gene expression

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SREBP-1 mediates activation of the low density lipoprotein receptor promoter by insulin and insulin-like growth factor-I.

27

1 reference

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Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

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Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms

29

1 reference

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ApoB100 secretion from HepG2 cells is decreased by the ACAT inhibitor CI-1011: an effect associated with enhanced intracellular degradation of ApoB

30

1 reference

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Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands

32

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Insulin-mediated inhibition of apolipoprotein B secretion requires an intracellular trafficking event and phosphatidylinositol 3-kinase activation: studies with brefeldin A and wortmannin in primary cultures of rat hepatocytes

34

1 reference

10.2337/DIABETES.52.10.2554

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Phosphoinositide 3-kinase activity is necessary for insulin-dependent inhibition of apolipoprotein B secretion by rat hepatocytes and localizes to the endoplasmic reticulum

35

1 reference

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Insulin inhibits the maturation phase of VLDL assembly via a phosphoinositide 3-kinase-mediated event

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Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion.

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Normal production rate of apolipoprotein B in LDL receptor-deficient mice

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1 reference

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Insulin suppression of VLDL apo B secretion is not mediated by the LDL receptor

40

1 reference

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Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes

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Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

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Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit

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Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors

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2'-Hydroxymatteucinol, a new C-methyl flavanone derivative from Matteccia orientalis; potent hypoglycemic activity in streptozotocin (STZ)-induced diabetic rat

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Identifiers

10.2337/DIABETES.52.10.2554

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

ResearchGate publication ID

0 references

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