(Q42160313)

English

Insulin-mediated inhibition of apolipoprotein B secretion requires an intracellular trafficking event and phosphatidylinositol 3-kinase activation: studies with brefeldin A and wortmannin in primary cultures of rat hepatocytes

scientific article published on January 1996

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Insulin-mediated inhibition of apolipoprotein B secretion requires an intracellular trafficking event and phosphatidylinositol 3-kinase activation: studies with brefeldin A and wortmannin in primary cultures of rat hepatocytes (English)

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

1 reference

based on heuristic

inferred from title

author name string

J D Sparks

1

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

T L Phung

2

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

M Bolognino

3

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

C E Sparks

4

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

language of work or name

0 references

publication date

1 January 1996

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Biochemical Journal

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

313 ( Pt 2)

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

567-574

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Monitoring of changes in hepatic fatty acid and glycerolipid metabolism during the starved-to-fed transition in vivo. Studies on awake, unrestrained rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

The insulin signaling system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Studies on the assembly of apolipoprotein B-100- and B-48-containing very low density lipoproteins in McA-RH7777 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Effect of fatty acids on lipid and apoprotein secretion and association in hepatocyte cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Role of insulin in lipoprotein secretion by cultured rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Apolipoprotein B: Structural and Metabolic Heterogeneity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

The production and utility of monoclonal antibodies to rat apolipoprotein B lipoproteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Compartmentation of the Golgi complex: brefeldin-A distinguishes trans-Golgi cisternae from the trans-Golgi network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Degradation of newly synthesized apolipoprotein B-100 in a pre-Golgi compartment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Insulin inhibits apolipoprotein B secretion in isolated human hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Cell-penetrating inhibitors of calpain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Brefeldin A: insights into the control of membrane traffic and organelle structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Inhibition of cysteine proteinases in lysosomes and whole cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Impaired hepatic apolipoprotein B and E translation in streptozotocin diabetic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

26 October 2017

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

29 May 2018

Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

29 May 2018

Inhibition of secretion of truncated apolipoproteins B by monomethylethanolamine is independent of the length of the apolipoprotein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

29 May 2018

Effects of insulin on lipoprotein secretion in rat hepatocyte cultures. The role of the insulin receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

29 May 2018

Secretion of high and low molecular weight phosphorylated apolipoprotein B by hepatocytes from control and diabetic rats. Phosphorylation of APO BH and APO BL.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

29 May 2018

Phosphatidylinositol-3-kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

29 May 2018

The role of pancreatic hormones in the regulation of lipid storage, oxidation and secretion in primary cultures of rat hepatocytes. Short- and long-term effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

29 May 2018

An essential role for a protein and lipid kinase complex in secretory protein sorting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

17 August 2018

Effects of acute hyperinsulinemia on VLDL triglyceride and VLDL apoB production in normal weight and obese individuals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

17 August 2018

Movement of apolipoprotein B into the lumen of microsomes from hepatocytes is disrupted in membranes enriched in phosphatidylmonomethylethanolamine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

17 August 2018

Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1216945

17 August 2018

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolysis and lipid-facilitated translocation are distinct but competitive processes that regulate secretion of apolipoprotein B in Hep G2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrahepatic assembly of very low density lipoproteins. Rate of transport out of the endoplasmic reticulum determines rate of secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Obese Zucker (fa/fa) Rats Are Resistant to Insulin′s Inhibitory Effect on Hepatic APO B Secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brefeldin A does not inhibit the movement of phosphatidylethanolamine from its sites for synthesis to the cell surface

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin effects on apolipoprotein B lipoprotein synthesis and secretion by primary cultures of rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The apolipoprotein B gene is constitutively expressed in HepG2 cells: regulation of secretion by oleic acid, albumin, and insulin, and measurement of the mRNA half-life

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of oleate and insulin on the production rates and cellular mRNA concentrations of apolipoproteins in HepG2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of proteinase inhibitors and amines on the lysosomal and non-lysosomal pathways of protein degradation in isolated rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the Protein Defect in Abetalipoproteinemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin modulation of hepatic synthesis and secretion of apolipoprotein B by rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver regrowth and apolipoprotein B secretion by rat hepatocytes following partial hepatectomy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein B is both integrated into and translocated across the endoplasmic reticulum membrane. Evidence for two functionally distinct pools

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies of the sites of intracellular degradation of apolipoprotein B in Hep G2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma very low density lipoproteins contain a single molecule of apolipoprotein B

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrahepatic assembly of very low density lipoproteins. Effect of fatty acids on triacylglycerol and apolipoprotein synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased sensitivity to the inhibitory effect of insulin on the secretion of very-low-density lipoprotein in cultured hepatocytes from fructose-fed rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunolocalization, quantitation and cellular heterogeneity of apolipoprotein B in rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8573094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ3130567

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

ResearchGate publication ID

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