(Q40647900)

22 September 2017

title

Evaluation of optimal expression cassette in retrovirus vector for beta-thalassemia gene therapy (English)

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22 September 2017

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Wen-Ji Dong

1

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22 September 2017

Bin Li

2

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22 September 2017

De-Pei Liu

3

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22 September 2017

Zhen-Xiang Zu

4

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22 September 2017

Jia Li

5

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22 September 2017

De-Long Hao

6

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22 September 2017

Guang Liu

7

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22 September 2017

Zhi-Chen Guo

8

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22 September 2017

Chih-Chuan Liang

9

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22 September 2017

publication date

1 June 2003

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22 September 2017

published in

Molecular Biotechnology

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22 September 2017

volume

24

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22 September 2017

issue

2

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22 September 2017

page(s)

127-140

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https://scigraph.springernature.com/pub.10.1385/mb:24:2:127

22 September 2017

exact match

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cites work

Full activity from human beta-globin locus control region transgenes requires 5'HS1, distal beta-globin promoter, and 3' beta-globin sequences.

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A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region

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12 December 2020

Position-independent, high-level expression of the human beta-globin gene in transgenic mice

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12 December 2020

Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene

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12 December 2020

[Retroviral transfer of a human beta-globin gene linked to beta locus control region hypersensitive site 2 into murine hematopoietic stem cells]

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12 December 2020

Evaluation of beta-globin gene therapy constructs in single copy transgenic mice.

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12 December 2020

Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression

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12 December 2020

Production of genetically stable high-titer retroviral vectors that carry a human gamma-globin gene under the control of the alpha-globin locus control region

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12 December 2020

Comparison of two kinds of methods to determine the titer of recombinant retrovirus containing beta-globin gene based on G418 selection

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12 December 2020

Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF

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12 December 2020

Adeno-associated virus 2-mediated transduction and erythroid lineage-restricted long-term expression of the human beta-globin gene in hematopoietic cells from homozygous beta-thalassemic mice

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12 December 2020

Preselection of retrovirally transduced bone marrow avoids subsequent stem cell gene silencing and age-dependent extinction of expression of human beta-globin in engrafted mice.

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12 December 2020

A major positive regulatory region located far upstream of the human alpha-globin gene locus

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12 December 2020

Analysis of adeno-associated virus-mediated ex vivo transferred human beta-globin gene in bone marrow engrafted mice

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12 December 2020

The expression of human alpha -like globin genes in transgenic mice mediated by bacterial artificial chromosome.

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12 December 2020

Long-term transfer and expression of the human beta-globin gene in a mouse transplant model

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12 December 2020

Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structure

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12 December 2020

Development of viral vectors for gene therapy of beta-chain hemoglobinopathies: optimization of a gamma-globin gene expression cassette

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12 December 2020

The major regulatory element upstream of the alpha-globin gene has classical and inducible enhancer activity.

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12 December 2020

High-level beta-globin expression after retroviral transfer of locus activation region-containing human beta-globin gene derivatives into murine erythroleukemia cells

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12 December 2020

Proper developmental control of human globin genes reproduced by transgenic mice containing a 160-kb BAC carrying the human beta-globin locus

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12 December 2020

Understanding alpha globin gene expression: a step towards effective gene therapy.

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12 December 2020

A majority of mice show long-term expression of a human beta-globin gene after retrovirus transfer into hematopoietic stem cells

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12 December 2020

Locus control regions of mammalian beta-globin gene clusters: combining phylogenetic analyses and experimental results to gain functional insights

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12 December 2020

Lineage-specific expression of a human beta-globin gene in murine bone marrow transplant recipients reconstituted with retrovirus-transduced stem cells

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12 December 2020

Generation of stable recombinant retroviruses containing the beta-globin genes linked to complex regulatory elements by using transient transfection

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12 December 2020

Development of a condensed locus control region cassette and testing in retrovirus vectors for A gamma-globin.

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12 December 2020

Recent advances in diagnosis of hemoglobinopathies

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12 December 2020

Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes.

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12 December 2020

Analysis of gamma-globin expression cassettes in retrovirus vectors

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12 December 2020

Characterization of the major regulatory element upstream of the human alpha-globin gene cluster

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12 December 2020

Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin

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12 December 2020

A functional enhancer suppresses silencing of a transgene and prevents its localization close to centrometric heterochromatin.

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12 December 2020

In vivo silencing of the human gamma-globin gene in murine erythroid cells following retroviral transduction

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12 December 2020

Improved retroviral vectors for gene transfer and expression

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12 December 2020

Conserved E boxes function as part of the enhancer in hypersensitive site 2 of the beta-globin locus control region. Role of basic helix-loop-helix proteins.

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12 December 2020

Identifiers

DOI

10.1385/MB:24:2:127

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Dimensions Publication ID

22 September 2017

1002506795

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