(Q40661662)

English

Cytosolic enzymes from rat tissues that activate the cooked meat mutagen metabolite N-Hydroxyamino-1-methyl-6- phenylimidazo[4,5-b]pyridine (N-OH-PhIP).

scientific article published on September 2001

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Cytosolic enzymes from rat tissues that activate the cooked meat mutagen metabolite N-Hydroxyamino-1-methyl-6- phenylimidazo[4,5-b]pyridine (N-OH-PhIP). (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

author name string

J G. Dubuisson

1

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

W S. Murph

2

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

S R. Griffin

3

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

J W. Gaubatz

4

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

publication date

1 September 2001

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Journal of Nutritional Biochemistry

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

518-528

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Cooked-food mutagens: current knowledge of formation and biological significance

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Carcinogenicities of heterocyclic amines in cooked food

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DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis

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Mutagenicity of pan residues and gravy from fried meat.

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Risk of death from cancer and ischaemic heart disease in meat and non-meat eaters

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Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research

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A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

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DNA modification by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats

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Metabolic activation pathway for the formation of DNA adducts of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rat extrahepatic tissues.

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Removal of DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the male Fischer-344 rat

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Analysis of DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine in rat and human tissues by alkaline hydrolysis and gas chromatography/electron capture mass spectrometry: validation by comparison with 32P-postlabeling

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DNA-binding and disposition of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat

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Inhibition of DNA adduct formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3-methylimidazo[4,5-f]quinoline by dietary indole-3-carbinol in female rats.

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Dose-dependence of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) carcinogenicity in rats.

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Carcinogenic factors in food with relevance to colon cancer development

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The formation of heart DNA adducts in F344 rat following dietary administration of heterocyclic amines

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Cardiotoxicity of heterocyclic amine food mutagens in cultured myocytes and in rats

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Heterocyclic amine-induced cancer and myocardial lesions in nonhuman primates

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7 January 2021

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Differential rates of metabolic activation and detoxication of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by different cytochrome P450 enzymes

1 reference

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7 January 2021

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Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon

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Enzymatic acetylation and sulfation of N-hydroxyarylamines in bacteria and rat livers.

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7 January 2021

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Role of sulfation and acetylation in the activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine to intermediates which bind DNA

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7 January 2021

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Enzymatic phase II activation of the N-hydroxylamines of IQ, MeIQx and PhIP by various organs of monkeys and rats.

1 reference

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7 January 2021

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Bioactivation of the proximal food mutagen 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) to DNA-binding species by human mammary gland enzymes

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Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Cross-striations, ultrastructure, and chronotropic response to isoproterenol

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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32P-postlabeling analysis of DNA adducts persisting for up to 42 weeks in the skin, epidermis and dermis of mice treated topically with 7,12-dimethylbenz[a]anthracene.

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Formation of DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in male Fischer-344 rats

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7 January 2021

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32P-postlabeling analysis of IQ, MeIQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MeIQx- and PhIP-treated monkeys.

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Detection of guanine-C8-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine adduct as a single spot on thin-layer chromatography by modification of the 32P-postlabeling method.

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Effect of glutathione depletion and inhibition of glucuronidation and sulfation on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism, PhIP-DNA adduct formation and unscheduled DNA synthesis in primary rat hepatocytes

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International Commission for Protection Against Environmental Mutagens and Carcinogens. ICPEMC Working Paper 7/1/3. Animal studies suggesting involvement of mutagen/carcinogen exposure in atherosclerosis

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1 reference

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Identification of N-(Deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine as the major adduct formed by the food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, with DNA

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Identifiers

10.1016/S0955-2863(01)00168-1

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

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