(Q40662972)

English

Regulation of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus at concentrations that inhibit calcineurin activity and involving the transcription factor CREB.

scientific article published on 20 February 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Regulation of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus at concentrations that inhibit calcineurin activity and involving the transcription factor CREB. (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

1 reference

based on heuristic

inferred from title

author name string

Elke Oetjen

1

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Daniela Grapentin

2

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Roland Blume

3

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Michael Seeger

4

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Doris Krause

5

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Anke Eggers

6

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Willhart Knepel

7

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

publication date

20 February 2003

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Naunyn-Schmiedeberg's Archives of Pharmacology

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Europe PubMed Central

PubMed publication ID

22 September 2017

367

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

227-236

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Cyclosporin A stimulation of glucose-induced insulin secretion in MIN6 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription factors of the NFAT family: regulation and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Luciferase reporter gene vectors for analysis of promoters and enhancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of insulin gene expression by glucose and calcium in transfected primary islet cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct properties of the cAMP-responsive element of the rat insulin I gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New perspectives into the molecular pathogenesis and treatment of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-transplant diabetes mellitus. The role of immunosuppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The immunosuppressive drugs cyclosporin A and FK506 inhibit calcineurin phosphatase activity and gene transcription mediated through the cAMP-responsive element in a nonimmune cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of insulin gene transcription by a Ca(2+)-responsive pathway involving calcineurin and nuclear factor of activated T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dominant repressor of cyclic adenosine 3',5'-monophosphate (cAMP)-regulated enhancer-binding protein activity inhibits the cAMP-mediated induction of the somatostatin promoter in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A protein kinase inhibitor gene reduces both basal and multihormone-stimulated prolactin gene transcription.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes mellitus and islet cell specific autoimmunity as adverse effects of immunsuppressive therapy by FK506/tacrolimus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mechanism of action of cyclosporin A and FK506.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nutrient regulation of insulin gene expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection. European FK506 Multicentre Liver Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of cyclic AMP response element-binding protein/cyclic AMP response element-mediated transcription by the immunosuppressive drugs cyclosporin A and FK506 depends on the promoter context.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-Jun represses the human insulin promoter activity that depends on multiple cAMP response elements

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription factor IID

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Successful islet transplantation for patients with diabetes--fact or fantasy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional regulation by the phosphorylation-dependent factor CREB

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatostatin gene upstream enhancer element activated by a protein complex consisting of CREB, Isl-1-like, and alpha-CBF-like transcription factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a novel calcium response element in the glucagon gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose regulation of gene transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane depolarization and calcium influx induce glucagon gene transcription in pancreatic islet cells through the cyclic AMP-responsive element

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of cAMP-responsive element-mediated gene transcription by cyclosporin A and FK506 after membrane depolarization

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of insulin gene transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Comparison of Tacrolimus (FK 506) and Cyclosporine for Immunosuppression in Liver Transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NFAT regulates insulin gene promoter activity in response to synergistic pathways induced by glucose and glucagon-like peptide-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diminished insulin secretory reserve in diabetic pancreas transplant and nondiabetic kidney transplant recipients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoplasmic calcium ions and other signalling events in insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic B cells are bursting, but how?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the Ca(2+)-dependent phosphatase calcineurin in gene transcription that is stimulated by cAMP through cAMP response elements

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene-specific transcriptional activity of the insulin cAMP-responsive element is conferred by NF-Y in combination with cAMP response element-binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the immunosuppressive drugs CsA and FK506 on intracellular signalling and gene regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of glucose-stimulated insulin release from beta TC3 cells and rodent islets by an analog of FK506

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic effects of cyclosporin A and FK 506 in liver transplant recipients

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644894

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00210-003-0694-7

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

release_3bwd5ga3bfhkjnvi6hu54mha64

1 reference

https://api.fatcat.wiki/v0/release/3bwd5ga3bfhkjnvi6hu54mha64

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

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