(Q40669367)

English

An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512.

scientific article published on 3 August 2015

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scholarly article

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Europe PubMed Central

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22 September 2017

An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512. (English)

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Europe PubMed Central

PubMed publication ID

22 September 2017

1

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31 May 2020

10

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31 May 2020

author name string

Elirosa Minniti

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26234198%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Maria Laura Greco

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26234198%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Laura Riccardi

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26234198%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Elena Simoni

5

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31 May 2020

Marino Convertino

6

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31 May 2020

Chiara Marchetti

7

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31 May 2020

Michela Rosini

8

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31 May 2020

Claudia Sissi

9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26234198%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Marco De Vivo

11

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31 May 2020

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publication date

3 August 2015

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22 September 2017

Chemical Communications

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31 May 2020

51

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31 May 2020

76

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31 May 2020

14310-14313

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31 May 2020

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

Topoisomerases and site-specific recombinases: similarities in structure and mechanism.

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

Recent developments of DNA poisons--human DNA topoisomerase IIα inhibitors--as anticancer agents

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

DNA Topology and Topoisomerases: Teaching a "Knotty" Subject

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

DNA topoisomerases and their poisoning by anticancer and antibacterial drugs

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

Drugging topoisomerases: lessons and challenges

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

F14512, a polyamine-vectorized anti-cancer drug, currently in clinical trials exhibits a marked preclinical anti-leukemic activity.

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

Contemporary challenges in the design of topoisomerase II inhibitors for cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

The use of divalent metal ions by type II topoisomerases.

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

Catalytic metal ions and enzymatic processing of DNA and RNA.

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

Molecular Simulations Highlight the Role of Metals in Catalysis and Inhibition of Type II Topoisomerase

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

Effects of magnesium and related divalent metal ions in topoisomerase structure and function.

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

Single-molecule pulling simulations can discern active from inactive enzyme inhibitors

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

Structural basis of gate-DNA breakage and resealing by type II topoisomerases

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

Bridging quantum mechanics and structure-based drug design

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

Novel DNA topoisomerase IIα inhibitors from combined ligand- and structure-based virtual screening

1 reference

https://api.crossref.org/works/10.1039%2FC5CC05065K

21 January 2018

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