(Q40697653)

22 September 2017

title

Involvement of NADPH: cytochrome P450 reductase in the activation of indoloquinone EO9 to free radical and DNA damaging species (English)

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22 September 2017

Bailey SM

1

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22 September 2017

Lewis AD

2

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22 September 2017

Patterson LH

3

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22 September 2017

Fisher GR

4

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22 September 2017

Knox RJ

5

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22 September 2017

Workman P

6

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22 September 2017

language of work or name

English

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publication date

1 August 2001

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22 September 2017

published in

Biochemical Pharmacology

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22 September 2017

volume

62

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22 September 2017

issue

4

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22 September 2017

page(s)

461-468

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EO9: a novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models

22 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900674-8

A randomized phase II study with two schedules of the novel indoloquinone EO9 in non-small-cell lung cancer: a study of the EORTC Early Clinical Studies Group (ECSG)

7 January 2021

1 reference

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Phase I and pharmacologic study of the novel indoloquinone bioreductive alkylating cytotoxic drug E09.

7 January 2021

1 reference

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Reduction of the indoloquinone anticancer drug EO9 by purified DT-diaphorase: a detailed kinetic study and analysis of metabolites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900674-8

Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900674-8

DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900674-8

The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900674-8

EO9: relationship between DT-diaphorase levels and response in vitro and in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900674-8

Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900674-8

DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900674-8

Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900674-8

Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900674-8

Relative importance of DT-diaphorase and hypoxia in the bioactivation of EO9 by human lung tumor cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900674-8

Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900674-8

Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900674-8

NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900674-8

Free radical formation and DNA strand breakage during metabolism of diaziquone by NAD(P)H quinone-acceptor oxidoreductase (DT-diaphorase) and NADPH cytochrome c reductase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900674-8

The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900674-8

The autoxidation of the reduced forms of EO9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900674-8

Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: indoloquinones and diaziridinyl benzoquinones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900674-8

10.1016/S0006-2952(01)00674-8

7 January 2021

Identifiers

DOI

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22 September 2017

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