(Q40726065)

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The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status.

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12058275%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12058275%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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9 November 2019

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Crespo NC

1

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9 November 2019

Delarue F

2

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9 November 2019

Carrico D

4

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9 November 2019

Hamilton AD

5

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9 November 2019

Sebti SM

6

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9 November 2019

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1 July 2002

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9 November 2019

Cell Death & Differentiation

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9 November 2019

9

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9 November 2019

7

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9 November 2019

702-709

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9 November 2019

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401023

0 references

Protein prenylation: molecular mechanisms and functional consequences

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

Inhibition of Ras and related guanosine triphosphate-dependent proteins as a therapeutic strategy for blocking malignant glioma growth: II--preclinical studies in a nude mouse model.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

CENP-E function at kinetochores is essential for chromosome alignment.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

Cytoplasmic dynein plays a role in mammalian mitotic spindle formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

21 January 2018

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401023

7 January 2021

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10.1038/SJ.CDD.4401023

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12058275%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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24 November 2022

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12058275%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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