(Q40794489)

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Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity

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scholarly article

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Europe PubMed Central

PubMed publication ID

23 September 2017

Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity (English)

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

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Robey R

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Europe PubMed Central

PubMed publication ID

23 September 2017

Mikhail Blagosklonny

4

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Blagosklonny MV

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23 September 2017

author name string

Giannakakou P

1

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Europe PubMed Central

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23 September 2017

Fojo T

3

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23 September 2017

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publication date

1 June 2001

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23 September 2017

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23 September 2017

20

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23 September 2017

29

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Europe PubMed Central

PubMed publication ID

23 September 2017

3806-3813

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Europe PubMed Central

PubMed publication ID

23 September 2017

Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition

1 reference

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21 January 2018

Involvement of p21 in mitotic exit after paclitaxel treatment in MCF-7 breast adenocarcinoma cell line

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21 January 2018

Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

Loss of function and p53 protein stabilization

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

Molecular effects of paclitaxel: myths and reality (a critical review).

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21 January 2018

Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

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21 January 2018

A p53-dependent mouse spindle checkpoint

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21 January 2018

Driving p53 response to Bax activation greatly enhances sensitivity to taxol by inducing massive apoptosis.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

WAF1, a potential mediator of p53 tumor suppression

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21 January 2018

A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

Abnormal centrosome amplification in the absence of p53.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

Mechanism of action of taxol

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

Microtubules and actin filaments: dynamic targets for cancer chemotherapy

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

T antigen is bound to a host protein in SY40-transformed cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

Characterization of the p53-dependent postmitotic checkpoint following spindle disruption

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

Paclitaxel (taxol)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

p53 activation in response to microtubule disruption is mediated by integrin-Erk signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

p53 mutations do not predict response to paclitaxel/radiation for nonsmall cell lung carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

The cellular response to p53: the decision between life and death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

One mechanism for cell type-specific regulation of the bax promoter by the tumor suppressor p53 is dictated by the p53 response element

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

Differential Taxol-dependent arrest of transformed and nontransformed cells in the G1 phase of the cell cycle, and specific-related mortality of transformed cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

Inactivation of p53 in a human ovarian cancer cell line increases the sensitivity to paclitaxel by inducing G2/M arrest and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

p53: death star

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

Induction of apoptosis by taxol and cisplatin and effect on cell cycle-related proteins in cisplatin-sensitive and -resistant human ovarian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

Role of BAX in the apoptotic response to anticancer agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

21 January 2018

p53 is associated with cellular microtubules and is transported to the nucleus by dynein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

7 January 2021

based on heuristic

inferred from DOI database lookup

Japan split over US aid for spy satellites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

7 January 2021

based on heuristic

inferred from DOI database lookup

Overexpression of p21(waf1) decreases G2-M arrest and apoptosis induced by paclitaxel in human sarcoma cells lacking both p53 and functional Rb protein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential modulation of paclitaxel-mediated apoptosis by p21Waf1 and p27Kip1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

7 January 2021

based on heuristic

inferred from DOI database lookup

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

7 January 2021

based on heuristic

inferred from DOI database lookup

Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 and chemosensitivity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204487

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.ONC.1204487

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Dimensions Publication ID

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

ResearchGate publication ID

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