(Q40822072)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26798039%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

Ceramide inhibits PKCθ by regulating its phosphorylation and translocation to lipid rafts in Jurkat cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26798039%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26798039%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

author name string

Rouba Hage-Sleiman

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26798039%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Asmaa B Hamze

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26798039%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Aimée F El-Hed

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26798039%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Lina Kozhaya

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26798039%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Sarah Kabbani

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26798039%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Ghassan Dbaibo

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26798039%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

publication date

1 August 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26798039%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26798039%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

volume

64

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26798039%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26798039%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

page(s)

869-886

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26798039%20AND%20SRC:MED&resulttype=core&format=json

Selective modulation of protein kinase C-theta during T-cell activation

5 March 2020

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BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2

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Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation

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Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation

21 January 2018

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The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

21 January 2018

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Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation

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Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells

21 January 2018

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PKC-θ function at the immunological synapse: prospects for therapeutic targeting

21 January 2018

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PKC theta ablation improves healing in a mouse model of muscular dystrophy

21 January 2018

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Targeting PKCθ in alloreactivity and graft-versus-host-disease: unanswered questions and therapeutic potential

21 January 2018

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PKCθ: a new target for selective immunosuppression.

21 January 2018

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The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells

21 January 2018

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Regulation of PKC-θ function by phosphorylation in T cell receptor signaling

21 January 2018

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Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation

21 January 2018

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Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes.

21 January 2018

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Characterization of protein kinase C theta activation loop autophosphorylation and the kinase domain catalytic mechanism

21 January 2018

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Germinal center kinase-like kinase overexpression in T cells as a novel biomarker in rheumatoid arthritis

21 January 2018

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Ceramide inhibits IL-2 production by preventing protein kinase C-dependent NF-kappaB activation: possible role in protein kinase Ctheta regulation.

21 January 2018

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21 January 2018

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21 January 2018

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Role for ceramide in cell cycle arrest.

21 January 2018

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Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest

21 January 2018

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21 January 2018

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Ceramide generation by two distinct pathways in tumor necrosis factor alpha-induced cell death

21 January 2018

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21 January 2018

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CD95(Fas/APO-1) signals ceramide generation independent of the effector stage of apoptosis

21 January 2018

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Ceramide is the key mediator of oxidative stress-induced apoptosis in retinal photoreceptor cells.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Selective involvement of ceramide in cytokine-induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappaB.

21 January 2018

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

21 January 2018

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21 January 2018

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Ceramide inhibition of NF-kappaB activation involves reverse translocation of classical protein kinase C (PKC) isoenzymes: requirement for kinase activity and carboxyl-terminal phosphorylation of PKC for the ceramide response

21 January 2018

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Ceramide inactivates cellular protein kinase Calpha

21 January 2018

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Cutting edge: quantitative imaging of raft accumulation in the immunological synapse

21 January 2018

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Phorbol 12-myristate 13-acetate protects Jurkat cells from methylglyoxal-induced apoptosis by preventing c-Jun N-terminal kinase-mediated leakage of cytochrome c in an extracellular signal-regulated kinase-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Sphingomyelin clustering is essential for the formation of microvilli.

21 January 2018

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Functional rafts in cell membranes

21 January 2018

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Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor

21 January 2018

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Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters

21 January 2018

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Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

21 January 2018

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Ceramide selectively displaces cholesterol from ordered lipid domains (rafts): implications for lipid raft structure and function

21 January 2018

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Ceramide displaces cholesterol from lipid rafts and decreases the association of the cholesterol binding protein caveolin-1.

21 January 2018

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Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis

21 January 2018

1 reference

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Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

21 January 2018

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Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes.

21 January 2018

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Molecular mechanisms of ceramide-mediated CD95 clustering

21 January 2018

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Ceramide enables fas to cap and kill.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Role of sphingomyelinase and ceramide in modulating rafts: do biophysical properties determine biologic outcome?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Raft ceramide in molecular medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Ceramide-enriched membrane domains--structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Regulation of protein kinase cascades by protein phosphatase 2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Type 2A protein phosphatase, the complex regulator of numerous signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

AMPK activity is regulated by calcium-mediated protein phosphatase 2A activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

PP2A mediated AMPK inhibition promotes HSP70 expression in heat shock response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Signalling by amino acid nutrients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Targeting of PKCzeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Multiple modes of interaction between Lck and CD28.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Protein Kinase C (PKC ): A Key Enzyme in T Cell Life and Death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Ceramide-mediated clustering is required for CD95-DISC formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-016-8787-9

Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells

21 January 2018

1 reference

12 December 2020

Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death

1 reference

12 December 2020

Cross-talk between ceramide and PKC activity in the control of apoptosis in WEHI-231

1 reference

12 December 2020

Inhibition of ceramide pathway does not affect ability of TNF-alpha to activate nuclear factor-kappa B.

1 reference

12 December 2020

Ceramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis

1 reference

12 December 2020

Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme

1 reference

12 December 2020

Ceramide activates the stress-activated protein kinases

1 reference

12 December 2020

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase

1 reference

12 December 2020

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1 reference

12 December 2020

Fumonisin toxicity and sphingolipid biosynthesis.

1 reference

12 December 2020

Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B.

1 reference

12 December 2020

CD28 and lipid rafts coordinate recruitment of Lck to the immunological synapse of human T lymphocytes

1 reference

12 December 2020

Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis

1 reference

12 December 2020

Mitochondrial free radical signal in ceramide-dependent apoptosis: a putative mechanism for neuronal death in Parkinson's disease.

1 reference

12 December 2020

NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta

1 reference

12 December 2020

Ceramide activates heterotrimeric protein phosphatase 2A.

1 reference

12 December 2020

Selective inhibition of protein kinase C isozymes by Fas ligation

1 reference

12 December 2020

AMP-activated protein kinase mediates T cell activation-induced expression of FasL and COX-2 via protein kinase C theta-dependent pathway in human Jurkat T leukemia cells

1 reference

12 December 2020

Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction

1 reference

12 December 2020

Fas (APO-1/CD95) signaling pathway is intact in radioresistant human glioma cells

1 reference

12 December 2020

Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal.

1 reference

12 December 2020

Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ

1 reference

12 December 2020

Ceramide inhibits phospholipase D in a cell-free system

1 reference

12 December 2020

10.1007/S12026-016-8787-9

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26798039%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

5 March 2020

1000805142

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26798039%20AND%20SRC:MED&resulttype=core&format=json