(Q40900721)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677703%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

title

Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677703%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677703%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

author name string

Hajime Akada

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677703%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Saeko Akada

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677703%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Robert E Hutchison

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677703%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Kazuhito Sakamoto

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677703%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Golam Mohi

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677703%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

publication date

1 July 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677703%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677703%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

volume

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677703%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677703%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

page(s)

1878-1889

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677703%20AND%20SRC:MED&resulttype=core&format=json

Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans

12 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Erk1 and Erk2 are required for maintenance of hematopoietic stem cells and adult hematopoiesis.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Endothelial and perivascular cells maintain haematopoietic stem cells

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Phase 2 study of CEP-701, an orally available JAK2 inhibitor, in patients with primary or post-polycythemia vera/essential thrombocythemia myelofibrosis

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

JNK signaling in apoptosis

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Cytokines regulating hematopoietic stem cell function

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Identification of an acquired JAK2 mutation in polycythemia vera

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

A gain-of-function mutation of JAK2 in myeloproliferative disorders

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Some speculations on the myeloproliferative syndromes.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

JAKs, STATs and Src kinases in hematopoiesis

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Thrombopoietin signal transduction requires functional JAK2, not TYK2

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Jak2 is essential for signaling through a variety of cytokine receptors

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Jaks and Stats in signaling by the cytokine receptor superfamily

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Inducible gene targeting in mice

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Kit regulates maintenance of quiescent hematopoietic stem cells.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Hematopoietic stem cells need two signals to prevent apoptosis; BCL-2 can provide one of these, Kitl/c-Kit signaling the other

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063883

Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells

19 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FSTEM.1711

Myeloproliferative disorders

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24677703

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Long-term outcome of treatment with ruxolitinib in myelofibrosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24677703

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24677703

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/STEM.1711

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677703%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677703%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

PubMed publication ID

24677703

1 reference