(Q40969125)

English

The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity

scientific article published on March 1999

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scholarly article

1 reference

Europe PubMed Central

25 September 2017

The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity (English)

1 reference

Europe PubMed Central

25 September 2017

1 reference

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author name string

Sun J

1

1 reference

Europe PubMed Central

25 September 2017

Qian Y

2

1 reference

Europe PubMed Central

25 September 2017

Chen Z

3

1 reference

Europe PubMed Central

25 September 2017

Marfurt J

4

1 reference

Europe PubMed Central

25 September 2017

Hamilton AD

5

1 reference

Europe PubMed Central

25 September 2017

Sebti SM

6

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Europe PubMed Central

25 September 2017

language of work or name

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publication date

1 March 1999

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Europe PubMed Central

25 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

25 September 2017

274

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Europe PubMed Central

25 September 2017

6930-6934

1 reference

Europe PubMed Central

25 September 2017

11

1 reference

Europe PubMed Central

25 September 2017

Protein prenylation: molecular mechanisms and functional consequences

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

Signal transduction from multiple Ras effectors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

A role for Rho in Ras transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

Inhibition of Ras prenylation: a novel approach to cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

Cancer cell cycles

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

Cell cycle checkpoints: preventing an identity crisis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

New functional activities for the p21 family of CDK inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.6930

21 January 2018

Identifiers

10.1074/JBC.274.11.6930

1 reference

Europe PubMed Central

25 September 2017

1 reference

Europe PubMed Central

25 September 2017

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