(Q41065976)

26 September 2017

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation (English)

1 reference

identical protein binding

26 September 2017

1 reference

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25643172%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Alexander K Buell

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25643172%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Georg Meisl

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25643172%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Thomas C. T. Michaels

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25643172%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Michele Vendruscolo

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25643172%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Tuomas Knowles

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25643172%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

Christopher M Dobson

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25643172%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

publication date

2 February 2015

1 reference

26 September 2017

Nature Chemical Biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25643172%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25643172%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25643172%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

229-234

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25643172%20AND%20SRC:MED&resulttype=core&format=json

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

1 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

The amyloid state and its association with protein misfolding diseases.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Membrane lipid co-aggregation with α-synuclein fibrils.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Direct observation of the interconversion of normal and toxic forms of α-synuclein

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

From α-synuclein to synaptic dysfunctions: new insights into the pathophysiology of Parkinson's disease.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

From macroscopic measurements to microscopic mechanisms of protein aggregation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

α-Synuclein synaptic pathology and its implications in the development of novel therapeutic approaches to cure Parkinson's disease

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Assays for α-synuclein aggregation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Effects of curvature and composition on α-synuclein binding to lipid vesicles

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Amyloidogenic protein-membrane interactions: mechanistic insight from model systems

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

α-Synuclein: membrane interactions and toxicity in Parkinson's disease

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

An analytical solution to the kinetics of breakable filament assembly

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Alpha-synuclein binds large unilamellar vesicles as an extended helix

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Role of alpha-synuclein in synaptic glutamate release

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Molecular anatomy of a trafficking organelle

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Characterization of the nanoscale properties of individual amyloid fibrils

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

The aggregation and fibrillation of alpha-synuclein

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Protein misfolding, functional amyloid, and human disease

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Structure and fluctuations of charged phosphatidylserine bilayers in the absence of salt

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

The association of alpha-synuclein with membranes affects bilayer structure, stability, and fibril formation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Protein misfolding, evolution and disease

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Alpha-synuclein in Lewy bodies

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Use of fluorescent probes to monitor molecular order and motions within liposome bilayers

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Kinetics of nucleation-controlled polymerization. A perturbation treatment for use with a secondary pathway

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

α-Synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Dual effect of amino modified polystyrene nanoparticles on amyloid β protein fibrillation

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Strategies to increase the reproducibility of protein fibrillization in plate reader assays

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Kinetics of sickle hemoglobin polymerization. II. A double nucleation mechanism.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

The behavior of alpha-synuclein in neurons.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

GM1 specifically interacts with alpha-synuclein and inhibits fibrillation

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Lipid binding inhibits alpha-synuclein fibril formation

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Dependence of alpha-synuclein aggregate morphology on solution conditions

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Analysis of protein aggregation kinetics.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019199

Metastability of Native Proteins and the Phenomenon of Amyloid Formation

19 August 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1750

Global Optimization by Basin-Hopping and the Lowest Energy Structures of Lennard-Jones Clusters Containing up to 110 Atoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1750

Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1750

Frequency Factors in a Landscape Model of Filamentous Protein Aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1750

The presence of an air-water interface affects formation and elongation of α-Synuclein fibrils

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25643172

12 December 2020

inferred from PubMed ID database lookup

The mode of α-synuclein binding to membranes depends on lipid composition and lipid to protein ratio

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25643172

12 December 2020

inferred from PubMed ID database lookup

A theory of linear and helical aggregations of macromolecules

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25643172

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NCHEMBIO.1750

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25643172%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 June 2020

1033765634

0 references

Fatcat ID

release_2husklfvcndknnmqdorx3jtidy

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/2husklfvcndknnmqdorx3jtidy

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25643172%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PubMed publication ID

25643172

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25643172%20AND%20SRC:MED&resulttype=core&format=json