(Q41166962)

English

Diminishing returns from beneficial mutations and pervasive epistasis shape the fitness landscape for rifampicin resistance in Pseudomonas aeruginosa

scientific article published on 27 September 2010

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

Diminishing returns from beneficial mutations and pervasive epistasis shape the fitness landscape for rifampicin resistance in Pseudomonas aeruginosa (English)

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

Pseudomonas aeruginosa

0 references

1 reference

based on heuristic

inferred from title

beneficial mutation

1 reference

based on heuristic

inferred from title

author name string

R C MacLean

1

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

G G Perron

2

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

A Gardner

3

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

language of work or name

0 references

publication date

27 September 2010

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

186

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

4

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

1345-1354

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

The population genetics of antibiotic resistance: integrating molecular mechanisms and treatment contexts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Antibiotic resistance and its cost: is it possible to reverse resistance?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

The properties of adaptive walks in evolving populations of fungus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Genome evolution and adaptation in a long-term experiment with Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Gene amplification and adaptive evolution in bacteria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Positive epistasis drives the acquisition of multidrug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Bacterial gene amplification: implications for the evolution of antibiotic resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

The distribution of fitness effects of beneficial mutations in Pseudomonas aeruginosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

The Beagle in a bottle

1 reference

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27 September 2017

The distribution of beneficial and fixed mutation fitness effects close to an optimum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Adaptive mutations in bacteria: high rate and small effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

The distribution of fitness effects of new mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Empirical fitness landscapes reveal accessible evolutionary paths

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Mutations of intermediate effect are responsible for adaptation in evolving Pseudomonas fluorescens populations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Darwinian evolution can follow only very few mutational paths to fitter proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Structural perspective on mutations affecting the function of multisubunit RNA polymerases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Perspective: Sign epistasis and genetic constraint on evolutionary trajectories

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

An empirical test of the mutational landscape model of adaptation using a single-stranded DNA virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

The genetic theory of adaptation: a brief history

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Microbial genetics: Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Use of the rpoB gene to determine the specificity of base substitution mutations on the Escherichia coli chromosome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Structural mechanism for rifampicin inhibition of bacterial rna polymerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Fitness effects of advantageous mutations in evolving Escherichia coli populations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Exceptional convergent evolution in a virus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Dynamics of adaptation and diversification: a 10,000-generation experiment with bacterial populations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Exponential increases of RNA virus fitness during large population transmissions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

27 September 2017

Contribution of gene amplification to evolution of increased antibiotic resistance in Salmonella typhimurium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

19 August 2018

Exploring the effect of sex on empirical fitness landscapes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

19 August 2018

The cost of multiple drug resistance in Pseudomonas aeruginosa.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

19 August 2018

An equivalence principle for the incorporation of favorable mutations in asexual populations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

19 August 2018

Fitness effects of fixed beneficial mutations in microbial populations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

19 August 2018

Mutational neighbourhood and mutation supply rate constrain adaptation in Pseudomonas aeruginosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

4 November 2018

Big-benefit mutations in a bacteriophage inhibited with heat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998316

4 November 2018

The population genetics of adaptation: the adaptation of DNA sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/20876562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variable epistatic effects between mutations at host recognition sites in phiX174 bacteriophage

1 reference

https://pubmed.ncbi.nlm.nih.gov/20876562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EXPERIMENTAL STUDIES OF PLEIOTROPY AND EPISTASIS IN ESCHERICHIA COLI. II. COMPENSATION FOR MALADAPTIVE EFFECTS ASSOCIATED WITH RESISTANCE TO VIRUS T4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20876562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

THE POPULATION GENETICS OF ADAPTATION: THE DISTRIBUTION OF FACTORS FIXED DURING ADAPTIVE EVOLUTION.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20876562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EVOLUTIONARY DYNAMICS OF FITNESS RECOVERY FROM THE DEBILITATING EFFECTS OF MULLER'S RATCHET.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20876562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1534/GENETICS.110.123083

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

ResearchGate publication ID

0 references

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