(Q22122013)

Dimensions Publication ID

Dimensions

22 September 2022

Peter D. Keightley

2

Peter D.

Keightley

1 reference

Dimensions Publication ID

Dimensions

1022243201

How much do we know about spontaneous human mutation rates?

22 September 2022

language of work or name

English

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publication date

August 2007

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published in

Nature Reviews Genetics

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volume

8

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page(s)

610-618

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issue

8

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cites work

1 reference

A molecular approach to estimating the human deleterious mutation rate.

31 March 2020

1 reference

The Nearly Neutral Theory of Molecular Evolution

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Quantifying the genomic decay paradox due to Muller's ratchet in human mitochondrial DNA

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Genetic variability under mutation selection balance

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The distribution of fitness effects of new deleterious amino acid mutations in humans

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On the allelic spectrum of human disease

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Theoretical models of selection and mutation on quantitative traits

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Experimental estimate of the abundance and effects of nearly neutral mutations in the RNA virus phi 6.

31 March 2020

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Distribution of fitness effects caused by random insertion mutations in Escherichia coli

31 March 2020

1 reference

The distribution of fitness effects caused by single-nucleotide substitutions in an RNA virus

31 March 2020

1 reference

Marginal fitness contributions of nonessential genes in yeast

31 March 2020

1 reference

Estimation of spontaneous genome-wide mutation rate parameters: whither beneficial mutations?

31 March 2020

1 reference

Spontaneous mutations in diploid Saccharomyces cerevisiae: more beneficial than expected

31 March 2020

1 reference

A comprehensive model of mutations affecting fitness and inferences for Arabidopsis thaliana.

31 March 2020

1 reference

High Frequency of Cryptic Deleterious Mutations in Caenorhabditis elegans

31 March 2020

1 reference

High mutation rate and predominance of insertions in the Caenorhabditis elegans nuclear genome.

31 March 2020

1 reference

Quantifying the Slightly Deleterious Mutation Model of Molecular Evolution

31 March 2020

1 reference

Inferring the distribution of mutational effects on fitness in Drosophila

31 March 2020

1 reference

Estimating selection on nonsynonymous mutations

31 March 2020

1 reference

Estimating the distribution of selection coefficients from phylogenetic data with applications to mitochondrial and viral DNA.

31 March 2020

1 reference

Estimating the distribution of fitness effects from DNA sequence data: implications for the molecular clock

31 March 2020

1 reference

Bayesian analysis suggests that most amino acid replacements in Drosophila are driven by positive selection

31 March 2020

1 reference

Scan of human genome reveals no new Loci under ancient balancing selection

31 March 2020

1 reference

Genetic variability maintained in a finite population due to mutational production of neutral and nearly neutral isoalleles

31 March 2020

1 reference

Elevated rates of nonsynonymous substitution in island birds.

31 March 2020

1 reference

Population size and molecular evolution on islands

31 March 2020

1 reference

Understanding the evolutionary fate of finite populations: the dynamics of mutational effects

31 March 2020

1 reference

The origins of genome complexity

31 March 2020

1 reference

Higher intensity of purifying selection on >90% of the human genes revealed by the intrinsic replacement mutation rates

31 March 2020

1 reference

The rate of adaptive evolution in enteric bacteria.

31 March 2020

1 reference

Selfish DNA: the ultimate parasite

31 March 2020

1 reference

Finding Functional Features in Saccharomyces Genomes by Phylogenetic Footprinting

31 March 2020

1 reference

Pattern of selective constraint in C. elegans and C. briggsae genomes

31 March 2020

1 reference

31 March 2020

1 reference

Adaptive evolution of non-coding DNA in Drosophila

31 March 2020

1 reference

Analysis of conserved noncoding DNA in Drosophila reveals similar constraints in intergenic and intronic sequences.

31 March 2020

1 reference

Ubiquitous selective constraints in the Drosophila genome revealed by a genome-wide interspecies comparison

31 March 2020

1 reference

Numerous potentially functional but non-genic conserved sequences on human chromosome 21

31 March 2020

1 reference

Human and rodent DNA sequence comparisons: a mosaic model of genomic evolution

31 March 2020

1 reference

Selective constraint in intergenic regions of human and mouse genomes.

31 March 2020

1 reference

Initial sequencing and comparative analysis of the mouse genome

31 March 2020

1 reference

Conserved non-genic sequences - an unexpected feature of mammalian genomes

31 March 2020

1 reference

Genomic selective constraints in murid noncoding DNA

31 March 2020

1 reference

The genomic rate of adaptive evolution

31 March 2020

1 reference

Initial sequence of the chimpanzee genome and comparison with the human genome

31 March 2020

1 reference

Human SNPs reveal no evidence of frequent positive selection

31 March 2020

1 reference

The genomic rate of adaptive amino acid substitution in Drosophila.

31 March 2020

1 reference

Adaptive protein evolution in Drosophila

31 March 2020

1 reference

Estimating the genomewide rate of adaptive protein evolution in Drosophila

31 March 2020

1 reference

Selection, recombination and demographic history in Drosophila miranda

31 March 2020

1 reference

Adaptation in the env gene of HIV-1 and evolutionary theories of disease progression.

31 March 2020

1 reference

Evidence for widespread degradation of gene control regions in hominid genomes

31 March 2020

1 reference

Fitness effects of advantageous mutations in evolving Escherichia coli populations

31 March 2020

1 reference

Distribution of fitness effects among beneficial mutations before selection in experimental populations of bacteria

31 March 2020

1 reference

An empirical test of the mutational landscape model of adaptation using a single-stranded DNA virus

31 March 2020

1 reference

Distributions of beneficial fitness effects in RNA.

31 March 2020

1 reference

Genetic architecture of traits associated with serpentine adaptation of Silene vulgaris.

31 March 2020

1 reference

Genetics of species differences in the wild annual sunflowers, Helianthus annuus and H. petiolaris

31 March 2020

1 reference

Pollinator preference and the evolution of floral traits in monkeyflowers (Mimulus)

31 March 2020

1 reference

The fitness effects of spontaneous mutations in Caenorhabditis elegans

31 March 2020

1 reference

Rate of deleterious mutation and the distribution of its effects on fitness in vesicular stomatitis virus

31 March 2020

1 reference

Increase of the spontaneous mutation rate in a long-term experiment with Drosophila melanogaster

31 March 2020

1 reference

The mutation rate and the distribution of mutational effects of viability and fitness in Drosophila melanogaster.

31 March 2020

1 reference

Gene action of new mutations in Arabidopsis thaliana

31 March 2020

1 reference

Simultaneous inference of selection and population growth from patterns of variation in the human genome

31 March 2020

1 reference

An evaluation of the molecular clock hypothesis using mammalian DNA sequences

31 March 2020

1 reference

Synonymous and nonsynonymous substitutions in mammalian genes and the nearly neutral theory

31 March 2020

1 reference

Selective constraint on noncoding regions of hominid genomes

31 March 2020

1 reference

Evolutionary constraints in conserved nongenic sequences of mammals.

31 March 2020

1 reference

Small fitness effect of mutations in highly conserved non-coding regions

31 March 2020

1 reference

PERSPECTIVE: SPONTANEOUS DELETERIOUS MUTATION.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRG2146

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1318193

1022243201

0 references

1318193

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference