(Q41211044)

28 September 2017

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title

The p53 tumour suppressor gene: a mediator of a G1 growth arrest and of apoptosis (English)

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28 September 2017

E Yonish-Rouach

1

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28 September 2017

publication date

1 October 1996

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28 September 2017

number of pages

7

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inferred from page(s)

published in

Experientia

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28 September 2017

volume

52

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28 September 2017

issue

10-11

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28 September 2017

page(s)

1001-1007

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A transcriptionally active DNA-binding site for human p53 protein complexes

28 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FBF01920109

Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920109

Endogenous p53 protein generated from wild-type alternatively spliced p53 RNA in mouse epidermal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920109

The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920109

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920109

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920109

Identification of a novel p53 promoter element involved in genotoxic stress-inducible p53 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920109

p53 functions as a cell cycle control protein in osteosarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920109

Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920109

p53-mediated cell death: relationship to cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920109

Growth suppression of Friend virus-transformed erythroleukemia cells by p53 protein is accompanied by hemoglobin production and is sensitive to erythropoietin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920109

Cytokines inhibit p53-mediated apoptosis but not p53-mediated G1 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920109

Regulation of p53-mediated apoptosis and cell cycle arrest by Steel factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920109

Bcl-2 blocks p53-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920109

Complementation by wild-type p53 of interleukin-6 effects on M1 cells: induction of cell cycle exit and cooperativity with c-myc suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920109

Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920109

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920109

Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920109

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01920109

p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation.

21 January 2018

1 reference

12 December 2020

p53 domains: identification and characterization of two autonomous DNA-binding regions.

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12 December 2020

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

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12 December 2020

Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene

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12 December 2020

Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: blocking p53-induced apoptosis unmasks G1 arrest.

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12 December 2020

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

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12 December 2020

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

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12 December 2020

Accumulation of wild-type p53 protein upon gamma-irradiation induces a G2 arrest-dependent immunoglobulin kappa light chain gene expression.

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12 December 2020

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

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12 December 2020

Relationships between G1 arrest and stability of the p53 and p21Cip1/Waf1 proteins following gamma-irradiation of human lymphoma cells

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12 December 2020

Thymocyte apoptosis induced by p53-dependent and independent pathways.

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12 December 2020

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

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12 December 2020

Transcriptional activation plays a role in the induction of apoptosis by transiently transfected wild-type p53

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12 December 2020

Essential role for p53-mediated transcription in E1A-induced apoptosis

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12 December 2020

Down-regulation of bcl-2 by p53 in breast cancer cells.

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12 December 2020

mdm2 expression is induced by wild type p53 activity

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12 December 2020

A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice

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12 December 2020

Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis

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12 December 2020

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

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12 December 2020

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

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12 December 2020

Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1

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12 December 2020

Increased activity of p53 in senescing fibroblasts

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12 December 2020

Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

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12 December 2020

Activation of the cryptic DNA binding function of mutant forms of p53.

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12 December 2020

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

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12 December 2020

Expression of a deletion mutant of the E2F1 transcription factor in fibroblasts lengthens S phase and increases sensitivity to S phase-specific toxins

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12 December 2020

Tumor spectrum analysis in p53-mutant mice

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12 December 2020

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

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12 December 2020

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein

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12 December 2020

Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways

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12 December 2020

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo

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12 December 2020

Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1

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12 December 2020

p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein

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12 December 2020

p53 is required for radiation-induced apoptosis in mouse thymocytes

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12 December 2020

WAF1, a potential mediator of p53 tumor suppression

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12 December 2020

Cooperative tumorigenic effects of germline mutations in Rb and p53

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12 December 2020

Wild-type p53 can down-modulate the activity of various promoters

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12 December 2020

Radiation-induced cell cycle arrest compromised by p21 deficiency

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12 December 2020

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

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12 December 2020

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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12 December 2020

DNA damage in human B cells can induce apoptosis, proceeding from G1/S when p53 is transactivation competent and G2/M when it is transactivation defective.

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12 December 2020

p53 mutations in human cancers

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12 December 2020

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

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12 December 2020

p53 and E2F-1 cooperate to mediate apoptosis

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12 December 2020

p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer

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12 December 2020

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein

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12 December 2020

No room at the p53 inn

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12 December 2020

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53.

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12 December 2020

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

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12 December 2020

Definition of a consensus binding site for p53

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12 December 2020

Sequence-specific transcriptional activation is essential for growth suppression by p53.

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12 December 2020

Radiation-induced G1 arrest is selectively mediated by the p53-WAF1/Cip1 pathway in human thyroid cells

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12 December 2020

bcl-2 inhibits wild-type p53-triggered apoptosis but not G1 cell cycle arrest and transactivation of WAF1 and bax

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12 December 2020

A temperature sensitive mutant of the human p53, Val138, arrests rat cell growth without induced expression of cip1/waf1/sdi1 after temperature shift-down

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12 December 2020

p21 is a universal inhibitor of cyclin kinases

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12 December 2020

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12 December 2020

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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12 December 2020

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

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12 December 2020

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

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12 December 2020

Growth factor modulation of p53-mediated growth arrest versus apoptosis

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12 December 2020

Participation of p53 protein in the cellular response to DNA damage

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12 December 2020

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

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12 December 2020

Induction of apoptosis by transiently transfected metabolically stable wt p53 in transformed cell lines

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12 December 2020

Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents

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12 December 2020

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

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12 December 2020

p53-mediated apoptosis in HeLa cells can be overcome by excess pRB

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12 December 2020

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

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12 December 2020

Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation.

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12 December 2020

Wild-type p53 activates transcription in vitro

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12 December 2020

Overcoming tumor necrosis factor and drug resistance of human tumor cell lines by combination treatment with anti-Fas antibody and drugs or toxins.

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12 December 2020

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

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12 December 2020

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53

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12 December 2020

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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12 December 2020

Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif

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12 December 2020

Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

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12 December 2020

Identification of p53 target genes through immune selection of genomic DNA: the cyclin G gene contains two distinct p53 binding sites

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12 December 2020

The tumor suppressor p53.

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12 December 2020

Cells expressing HPV16 E7 continue cell cycle progression following DNA damage induced p53 activation.

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12 December 2020

Transcriptional activation by p53 correlates with suppression of growth but not transformation.

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12 December 2020

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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12 December 2020

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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12 December 2020

Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.

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12 December 2020

A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization

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12 December 2020

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

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12 December 2020

Cyclin G is a transcriptional target of the p53 tumor suppressor protein

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12 December 2020

Human p53 binds DNA as a protein homodimer but monomeric variants retain full transcription transactivation activity

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12 December 2020

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

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12 December 2020

Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA

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12 December 2020

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

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12 December 2020

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

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12 December 2020

Structural aspects of the p53 protein in relation to gene evolution

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12 December 2020

Identification of p53 as a sequence-specific DNA-binding protein

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12 December 2020

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

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12 December 2020

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development

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12 December 2020

Inhibition of viral and cellular promoters by human wild-type p53

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12 December 2020

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

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12 December 2020

Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents

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12 December 2020

Identifiers

DOI

10.1007/BF01920109

1 reference

28 September 2017

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