(Q41293013)

29 September 2017

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title

Pharmacokinetic individualisation of zidovudine therapy. Current state of pharmacokinetic-pharmacodynamic relationships (English)

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29 September 2017

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4

J H Beijnen

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29 September 2017

R M Hoetelmans

1

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29 September 2017

D M Burger

series ordinal

2

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29 September 2017

P L Meenhorst

series ordinal

3

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29 September 2017

publication date

1 April 1996

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Clinical Pharmacokinetics

29 September 2017

published in

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29 September 2017

volume

30

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29 September 2017

issue

4

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29 September 2017

page(s)

314-327

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https://scigraph.springernature.com/pub.10.2165/00003088-199630040-00004

29 September 2017

exact match

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cites work

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Decreased and variable systemic availability of zidovudine in patients with AIDS if administered with a meal.

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Prolonged, but not diminished, zidovudine absorption induced by a high-fat breakfast.

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Azidothymidine-induced cytotoxicity and incorporation into DNA in the human colon tumor cell line HCT-8 is enhanced by methotrexate in vitro and in vivo

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Clinical pharmacokinetics of zidovudine. An overview of current data

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Intracellular zidovudine (ZDV) and ZDV phosphates as measured by a validated combined high-pressure liquid chromatography-radioimmunoassay procedure

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Intracellular monitoring of nucleoside analogues: a new frontier

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Concise overview of the clinical pharmacokinetics of dideoxynucleoside antiretroviral agents

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Erratic zidovudine bioavailability in HIV seropositive patients

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Evidence of in vitro development of drug resistance to azidothymidine in T-lymphocytic leukemia cell lines (Jurkat E6-1/AZT-100) and in pediatric patients with HIV-1 infection

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Therapy for human immunodeficiency virus infection

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12 December 2020

Catabolism of 3'-azido-3'-deoxythymidine in hepatocytes and liver microsomes, with evidence of formation of 3'-amino-3'-deoxythymidine, a highly toxic catabolite for human bone marrow cells

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Absorption of zidovudine in patients with diarrhoea

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Plasma and cerebrospinal fluid pharmacokinetics of 3'-azido-3'-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases

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Long-term inhibition of human T-lymphotropic virus type III/lymphadenopathy-associated virus (human immunodeficiency virus) DNA synthesis and RNA expression in T cells protected by 2',3'-dideoxynucleosides in vitro

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Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase

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Zidovudine disposition in patients with severe renal impairment: influence of hemodialysis

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Clinical pharmacokinetics of zidovudine. An update

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High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR

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Pharmacokinetics of oral zidovudine (azidothymidine) in patients with AIDS when administered with and without a high-fat meal

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Acquired immunodeficiency syndrome. Cerebrospinal fluid findings in patients before and during long-term oral zidovudine therapy

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12 December 2020

The treatment of 12 HIV-infected children with zidovudine

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12 December 2020

Declining incidence of AIDS dementia complex after introduction of zidovudine treatment

1 reference

12 December 2020

Comparative pharmacokinetics of zidovudine in healthy volunteers and in patients with AIDS with and without hepatic disease

1 reference

12 December 2020

Pharmacokinetics of zidovudine phosphorylation in peripheral blood mononuclear cells from patients infected with human immunodeficiency virus

1 reference

12 December 2020

Effects of 2?,3?-dideoxynucleosides on mammalian cells and viruses

1 reference

12 December 2020

Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex

1 reference

12 December 2020

Intracellular metabolism of 3'-azidothymidine in isolated human peripheral blood mononuclear cells

1 reference

12 December 2020

Pharmacokinetic evaluations of low- and high-dose zidovudine plus high-dose acyclovir in patients with symptomatic human immunodeficiency virus infection

1 reference

12 December 2020

Effects of zidovudine in 365 consecutive patients with AIDS or AIDS-related complex

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Zidovudine. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy

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12 December 2020

Zidovudine phosphorylation in HIV-infected patients and seronegative volunteers

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12 December 2020

Evaluation of saliva as a specimen for monitoring zidovudine therapy in HIV-infected patients

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12 December 2020

Molecular targets for AIDS therapy

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12 December 2020

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12 December 2020

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1 reference

12 December 2020

Inhibition of the RNase H activity of HIV reverse transcriptase by azidothymidylate

1 reference

12 December 2020

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1 reference

12 December 2020

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1 reference

12 December 2020

A pilot study of low-dose zidovudine in human immunodeficiency virus infection

1 reference

12 December 2020

Neuropsychological outcome of zidovudine (AZT) treatment of patients with AIDS and AIDS-related complex

1 reference

12 December 2020

Biochemical pharmacology of zidovudine in human T-lymphoblastoid cells (CEM).

1 reference

12 December 2020

Concentrations of phosphorylated zidovudine (ZDV) in patient leukocytes do not correlate with ZDV dose or plasma concentrations

1 reference

12 December 2020

The pharmacokinetics of zidovudine administered by continuous infusion in children

1 reference

12 December 2020

Cellular pharmacology of 3'-azido-3'-deoxythymidine with evidence of incorporation into DNA of human bone marrow cells

1 reference

12 December 2020

Toxic effects of zidovudine in asymptomatic human immunodeficiency virus-infected individuals with CD4+ cell counts of 0.50 x 10(9)/L or less. Detailed and updated results from protocol 019 of the AIDS Clinical Trials Group

1 reference

12 December 2020

Pharmacokinetic variability of zidovudine in HIV-infected individuals: subgroup analysis and drug interactions

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12 December 2020

Incorporation of 3'-azido-3'-deoxythymidine into cellular DNA and its removal in a human leukemic cell line

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12 December 2020

A randomized controlled trial of a reduced daily dose of zidovudine in patients with the acquired immunodeficiency syndrome. The AIDS Clinical Trials Group

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12 December 2020

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Human immunodeficiency virus type 1 infection and myopathy: clinical relevance of zidovudine therapy

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12 December 2020

Effects of 3'-azido-3'-deoxythymidine on the deoxynucleotide triphosphate pools of cultured human cells

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12 December 2020

A method for the quantification of intracellular zidovudine nucleotides

1 reference

12 December 2020

The effect of a protein meal on zidovudine pharmacokinetics in HIV-infected patients

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12 December 2020

Double blind dose-response study of zidovudine in AIDS and advanced HIV infection. Nordic Medical Research Councils' HIV Therapy Group

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12 December 2020

Clinical pharmacokinetics of zidovudine: inter and intraindividual variability and relationship to long term efficacy and toxicity.

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12 December 2020

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12 December 2020

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12 December 2020

Enzymatic assay for measurement of zidovudine triphosphate in peripheral blood mononuclear cells

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12 December 2020

A review of the pharmacokinetics of zidovudine in man.

1 reference

12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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1 reference

12 December 2020

Correlates of zidovudine phosphorylation with markers of HIV disease progression and drug toxicity

1 reference

12 December 2020

Zidovudine pharmacokinetics in zidovudine-induced bone marrow toxicity.

1 reference

12 December 2020

Penetration of zidovudine into the cerebrospinal fluid of patients infected with HIV

1 reference

12 December 2020

Drug interactions with zidovudine phosphorylation in vitro.

1 reference

12 December 2020

Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds

1 reference

12 December 2020

Plasma viremia in human immunodeficiency virus infection

1 reference

12 December 2020

10.2165/00003088-199630040-00004

Identifiers

DOI

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Dimensions Publication ID

29 September 2017

1040394032

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