(Q41327338)

English

Rational design of a beta-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 A crystal structure of wt SHV-1 complex with a penam sulfone

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scholarly article

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Europe PubMed Central

PMC publication ID

29 September 2017

Rational design of a beta-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 A crystal structure of wt SHV-1 complex with a penam sulfone (English)

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Europe PubMed Central

PMC publication ID

29 September 2017

Robert A Bonomo

9

object named as

Robert A Bonomo

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29 September 2017

3

object named as

Monica A Totir

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29 September 2017

author name string

Pius S Padayatti

1

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29 September 2017

Anjaneyulu Sheri

2

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29 September 2017

Marion S Helfand

4

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29 September 2017

Marianne P Carey

5

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29 September 2017

Vernon E Anderson

6

1 reference

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29 September 2017

Paul R Carey

7

1 reference

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29 September 2017

Christopher R Bethel

8

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29 September 2017

John D Buynak

10

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29 September 2017

Focco van den Akker

11

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29 September 2017

language of work or name

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publication date

1 October 2006

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Europe PubMed Central

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29 September 2017

Journal of the American Chemical Society

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29 September 2017

128

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Europe PubMed Central

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29 September 2017

40

1 reference

Europe PubMed Central

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29 September 2017

13235-13242

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Understanding the longevity of the beta-lactam antibiotics and of antibiotic/beta-lactamase inhibitor combinations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Clavulanic acid inactivation of SHV-1 and the inhibitor-resistant S130G SHV-1 beta-lactamase. Insights into the mechanism of inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Beta-lactamase inhibitors: evolving compounds for evolving resistance targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

The discovery and development of modified penicillin- and cephalosporin-derived beta-lactamase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Tazobactam inactivation of SHV-1 and the inhibitor-resistant Ser130 -->Gly SHV-1 beta-lactamase: insights into the mechanism of inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Tazobactam forms a stoichiometric trans-enamine intermediate in the E166A variant of SHV-1 beta-lactamase: 1.63 A crystal structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Following the Reactions of Mechanism-Based Inhibitors with β-Lactamase by Raman Crystallography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Clinical role of beta-lactam/beta-lactamase inhibitor combinations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Ultrahigh resolution structure of a class A beta-lactamase: on the mechanism and specificity of the extended-spectrum SHV-2 enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Beta-lactamases: a survey of protein diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

The impact of beta-lactamases on the development of novel antimicrobial agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Molecular dynamics at the root of expansion of function in the M69L inhibitor-resistant TEM beta-lactamase from Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Inactivation of CMY-2 beta-lactamase by tazobactam: initial mass spectroscopic characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Inhibition of the SHV-1 beta-lactamase by sulfones: crystallographic observation of two reaction intermediates with tazobactam

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Molecular basis of antibiotic resistance and beta-lactamase inhibition by mechanism-based inactivators: perspectives and future directions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

The high resolution crystal structure for class A beta-lactamase PER-1 reveals the bases for its increase in breadth of activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Structure of the SHV-1 beta-lactamase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Clinical inhibitor-resistant mutants of the beta-lactamase TEM-1 at amino-acid position 69. Kinetic analysis and molecular modelling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Elimination of the hydrolytic water molecule in a class A beta-lactamase mutant: crystal structure and kinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Kinetic interactions of tazobactam with beta-lactamases from all major structural classes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

The role of lysine-234 in beta-lactamase catalysis probed by site-directed mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

In search of new lead compounds for trypanosomiasis drug design: a protein structure-based linked-fragment approach.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Beta-lactamase TEM1 of E. coli. Crystal structure determination at 2.5 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Site-directed mutagenesis at the active site of Escherichia coli TEM-1 beta-lactamase. Suicide inhibitor-resistant mutants reveal the role of arginine 244 and methionine 69 in catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Chemical studies on the inactivation of Escherichia coli RTEM β-lactamase by clavulanic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Kinetic studies on the inactivation of Escherichia coli RTEM β-lactamase by clavulanic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

1 October 2017

Kinetic analysis of an inhibitor-resistant variant of the OHIO-1 beta-lactamase, an SHV-family class A enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

11 June 2018

β-Lactamase inactivation by mechanism-based reagents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

11 June 2018

Molecular mechanisms of antibiotic resistance: QM/MM modelling of deacylation in a class A beta-lactamase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

19 August 2018

High resolution crystal structures of the trans-enamine intermediates formed by sulbactam and clavulanic acid and E166A SHV-1 {beta}-lactamase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

19 August 2018

Inhibition of TEM-2 beta-lactamase from Escherichia coli by clavulanic acid: observation of intermediates by electrospray ionization mass spectrometry.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

19 August 2018

PRODRG, a program for generating molecular topologies and unique molecular descriptors from coordinates of small molecules.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2593906

19 August 2018

Difference density quality (DDQ): a method to assess the global and local correctness of macromolecular crystal structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/17017804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of inhibition of the class A beta -lactamases PC1 and TEM-1 by tazobactam. Observation of reaction products by electrospray ionization mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/17017804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://pubmed.ncbi.nlm.nih.gov/17017804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Penicillanic acid sulfone: nature of irreversible inactivation of RTEM beta-lactamase from Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/17017804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

6-(Methoxymethylene)penicillanic acid: inactivator of RTEM .beta.-lactamase from Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/17017804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Penicillanic acid sulfone: an unexpected isotope effect in the interaction of 6.alpha.- and 6.beta.-monodeuterio and of 6,6-dideuterio derivatives with RTEM .beta.-lactamase from Escherichia coli. Crystal structure of penicillanic acid sulfone

1 reference

https://pubmed.ncbi.nlm.nih.gov/17017804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Lactamase proceeds via an acyl-enzyme intermediate. Interaction of the Escherichia coli RTEM enzyme with cefoxitin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17017804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of the RTEM beta-lactamase from Escherichia coli. Interaction of penam sulfones with enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/17017804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of RTEM beta-lactamase from Escherichia coli by clavulanic acid and 9-deoxyclavulanic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/17017804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JA063715W

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

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