(Q41359348)

29 September 2017

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title

Mechanism of antigen-driven somatic hypermutation of rearranged immunoglobulin V(D)J genes in the mouse (English)

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29 September 2017

Steele EJ

1

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29 September 2017

Rothenfluh HS

series ordinal

2

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29 September 2017

Blanden RV

series ordinal

3

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29 September 2017

language of work or name

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1 February 1997

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Immunology & Cell Biology

29 September 2017

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29 September 2017

75

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29 September 2017

1

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29 September 2017

82-95

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Hypothesis: somatic hypermutation by gene conversion via the error prone DNA----RNA----DNA information loop

29 September 2017

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Defining the nucleic acid substrate for somatic hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Affinity maturation of lymphocyte receptors and positive selection of T cells in the thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Might gene conversion be the mechanism of somatic hypermutation of mammalian immunoglobulin genes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Somatic hypermutation: how many mechanisms diversify V region sequences?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

The efficiency of antibody affinity maturation: can the rate of B-cell division be limiting?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

21 January 2018

Somatic hypermutation

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

A hyperconversion mechanism generates the chicken light chain preimmune repertoire.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Germ line maintenance of the pseudogene donor pool for somatic immunoglobulin gene conversion in chickens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Restricted VH gene usage and generation of antibody diversity in rabbit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Somatic mutations of immunoglobulin variable genes are restricted to the rearranged V gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Generation of immunoglobulin variable gene diversity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Clusters of point mutations are found exclusively around rearranged antibody variable genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Somatic mutation in constant regions of mouse lambda 1 light chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Expression, allelic exclusion and somatic mutation of mouse immunoglobulin kappa genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

The T-cell-independent immune response to the hapten NP uses a large repertoire of heavy chain genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Antigen-driven selection of virgin and memory B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Mutation drift and repertoire shift in the maturation of the immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Maturation of the immune response in germinal centers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Locus-specific somatic hypermutation in germinal centre T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

The dynamic nature of the antibody repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Distribution of mutations around rearranged heavy-chain antibody variable-region genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

An immunoglobulin promoter region is unaltered by DNA rearrangement and somatic mutation during B-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Somatic hypermutation in 5' flanking regions of heavy chain antibody variable regions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Somatic hypermutation of an immunoglobulin mu heavy chain transgene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Analysis of sequence transfers resembling gene conversion in a mouse antibody transgene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Mutation in a reporter gene depends on proximity to and transcription of immunoglobulin variable transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Reciprocal homologous recombination in or near antibody VDJ genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Analysis of patterns of DNA sequence variation in flanking and coding regions of murine germ-line immunoglobulin heavy-chain variable genes: evolutionary implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Evolution of V genes: DNA sequence structure of functional germline genes and pseudogenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

DNA polymerase III holoenzyme: structure and function of a chromosomal replicating machine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Maturation and dispersal of B-cell clones during T cell-dependent antibody responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

B cell activation, tolerance and antigen-presenting function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

A lambda 1 transgene under the control of a heavy chain promoter and enhancer does not undergo somatic hypermutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Efficient integration of an intron RNA into double-stranded DNA by reverse splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Timing, genetic requirements and functional consequences of somatic hypermutation during B-cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

The centre of hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Mechanism of antigen-driven selection in germinal centres

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Codon bias targets mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

7 January 2021

Somatic hyperconversion diversifies the single Vh gene of the chicken with a high incidence in the D region

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

7 January 2021

Chicken IgL variable region gene conversions display pseudogene donor preference and 5' to 3' polarity

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

7 January 2021

Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

7 January 2021

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

7 January 2021

Enhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations.

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

7 January 2021

Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

7 January 2021

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

7 January 2021

https://api.crossref.org/works/10.1038%2FICB.1997.12

1 reference

7 January 2021

Inside an intron invasion

1 reference

https://api.crossref.org/works/10.1038%2FICB.1997.12

7 January 2021

Identifiers

DOI

10.1038/ICB.1997.12

1 reference

29 September 2017

1 reference