(Q41412946)

13 July 2018

title

Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms (English)

1 reference

13 July 2018

Solute carrier family 16 member 11

main subject

1 reference

pyruvate transmembrane transporter activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

30

Eric S Lander

0 references

Gaelen Guzman

Gaelen Guzman

11

0 references

Josep Maria Mercader

Josep M Mercader

3

0 references

Marcin von Grotthuss

8

Marcin von Grotthuss

1 reference

13 July 2018

Lorena Orozco

25

Lorena Orozco

1 reference

13 July 2018

Melissa Gymrek

5

Melissa Gymrek

1 reference

13 July 2018

Stuart Schreiber

27

Stuart L Schreiber

1 reference

13 July 2018

author name string

Victor Rusu

1

1 reference

13 July 2018

Eitan Hoch

2

1 reference

13 July 2018

Danielle E Tenen

4

1 reference

13 July 2018

Christina R Hartigan

6

1 reference

13 July 2018

Michael DeRan

7

1 reference

13 July 2018

Pierre Fontanillas

9

1 reference

13 July 2018

Alexandra Spooner

10

1 reference

13 July 2018

Amy A Deik

12

1 reference

13 July 2018

Kerry A Pierce

13

1 reference

13 July 2018

Courtney Dennis

14

1 reference

13 July 2018

Clary B Clish

15

1 reference

13 July 2018

Steven A Carr

16

1 reference

13 July 2018

Bridget K Wagner

17

1 reference

13 July 2018

Monica Schenone

18

1 reference

13 July 2018

Maggie C Y Ng

19

1 reference

13 July 2018

Brian H Chen

20

1 reference

13 July 2018

MEDIA Consortium

21

1 reference

13 July 2018

SIGMA T2D Consortium

22

1 reference

13 July 2018

Federico Centeno-Cruz

23

1 reference

13 July 2018

Carlos Zerrweck

24

1 reference

13 July 2018

David M Altshuler

26

1 reference

13 July 2018

Jose C Florez

28

1 reference

13 July 2018

Suzanne B R Jacobs

29

1 reference

13 July 2018

language of work or name

English

0 references

publication date

1 June 2017

1 reference

13 July 2018

published in

Cell

1 reference

13 July 2018

volume

170

1 reference

13 July 2018

issue

1

1 reference

13 July 2018

page(s)

199-212.e20

1 reference

13 July 2018

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5562285/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/5562285

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Type 2 diabetes: genetic data sharing to advance complex disease research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Mitochondrial dysfunction in fatty acid oxidation disorders: insights from human and animal studies

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

WASP: allele-specific software for robust molecular quantitative trait locus discovery

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

The support of human genetic evidence for approved drug indications

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Lumacaftor-Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Genetics of type 2 diabetes-pitfalls and possibilities

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Efficacy and safety of evolocumab in reducing lipids and cardiovascular events.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Efficacy and safety of alirocumab in reducing lipids and cardiovascular events

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Update on developments with SGLT2 inhibitors in the management of type 2 diabetes

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Improved vectors and genome-wide libraries for CRISPR screening

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Energy metabolism in the liver

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Imaging mitochondrial flux in single cells with a FRET sensor for pyruvate

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Genome-wide association study identifies three novel loci for type 2 diabetes

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Effect of ivacaftor on CFTR forms with missense mutations associated with defects in protein processing or function

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Validating therapeutic targets through human genetics

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

The SLC16 gene family - structure, role and regulation in health and disease

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Systematic localization of common disease-associated variation in regulatory DNA

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

An integrated encyclopedia of DNA elements in the human genome

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Fast gapped-read alignment with Bowtie 2

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Mechanisms for insulin resistance: common threads and missing links

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Human metabolic individuality in biomedical and pharmaceutical research

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

METAL: fast and efficient meta-analysis of genomewide association scans

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Prevalence and distribution of type 2 diabetes mellitus in Mexican adult population: a probabilistic survey

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Diacylglycerol-mediated insulin resistance

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Evidence for a homodimeric structure of human monocarboxylate transporter 8.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

A Bayesian measure of the probability of false discovery in genetic epidemiology studies

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Genomic maps and comparative analysis of histone modifications in human and mouse

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Three-dimensional crystallization of the Escherichia coli glycerol-3-phosphate transporter: a member of the major facilitator superfamily

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Application of 3D-Jury, GRDB, and Verify3D in fold recognition

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Genetic cause of hyperglycaemia and response to treatment in diabetes

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

GeneSilico protein structure prediction meta-server.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Oral antihyperglycemic therapy for type 2 diabetes: scientific review

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Comparison of sequence profiles. Strategies for structural predictions using sequence information

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Triglycerides and disease.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Comparative protein modelling by satisfaction of spatial restraints

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Cytoplasmic pH and free Mg2+ in lymphocytes

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Improved whole-chromosome phasing for disease and population genetic studies

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

A genetic diagnosis of HNF1A diabetes alters treatment and improves glycaemic control in the majority of insulin-treated patients.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

The double puzzle of diabetes

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562285

Targeted Allelic Expression Profiling in Human Islets Identifiescis-Regulatory Effects for Multiple Variants Identified by Type 2 Diabetes Genome-Wide Association Studies

19 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28666119

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2017.06.011

1 reference

13 July 2018

PMC publication ID

5562285

1 reference

13 July 2018

PubMed publication ID

28666119

1 reference

13 July 2018