(Q41514506)

English

Strategies to make protein serine/threonine (PP1, calcineurin) and tyrosine phosphatases (PTP1B) druggable: achieving specificity by targeting substrate and regulatory protein interaction sites

scientific article published on 26 February 2015

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

Strategies to make protein serine/threonine (PP1, calcineurin) and tyrosine phosphatases (PTP1B) druggable: achieving specificity by targeting substrate and regulatory protein interaction sites (English)

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

author name string

Wolfgang Peti

1

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

Rebecca Page

2

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

language of work or name

0 references

publication date

26 February 2015

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Europe PubMed Central

PMC publication ID

2 October 2017

Bioorganic & Medicinal Chemistry

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

23

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

12

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

2781-2785

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

Intrinsically disordered proteins in cellular signalling and regulation.

1 reference

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Targeting the disordered C terminus of PTP1B with an allosteric inhibitor

1 reference

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Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code

1 reference

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Cancerous inhibitor of protein phosphatase 2A, an emerging human oncoprotein and a potential cancer therapy target.

1 reference

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Targeting the untargetable: recent advances in the selective chemical modulation of protein phosphatase-1 activity.

1 reference

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The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin

1 reference

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NIPP1 maintains EZH2 phosphorylation and promoter occupancy at proliferation-related target genes

1 reference

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Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells

1 reference

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6 June 2018

The Molecular Basis for Substrate Specificity of the Nuclear NIPP1:PP1 Holoenzyme

1 reference

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6 June 2018

Small molecule tools for functional interrogation of protein tyrosine phosphatases

1 reference

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Balanced interactions of calcineurin with AKAP79 regulate Ca2+–calcineurin–NFAT signaling

1 reference

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Protein phosphatases and Alzheimer's disease

1 reference

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Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease.

1 reference

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Structural basis for protein phosphatase 1 regulation and specificity

1 reference

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Conformation-Sensing Antibodies Stabilize the Oxidized Form of PTP1B and Inhibit Its Phosphatase Activity

1 reference

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Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development

1 reference

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6 June 2018

Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis

1 reference

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6 June 2018

Molecular investigations of the structure and function of the protein phosphatase 1-spinophilin-inhibitor 2 heterotrimeric complex

1 reference

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Inside the human cancer tyrosine phosphatome

1 reference

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6 June 2018

Interaction of calcineurin with substrates and targeting proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451382

6 June 2018

Flexibility in the PP1:spinophilin holoenzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451382

6 June 2018

Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451382

6 June 2018

The extended PP1 toolkit: designed to create specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451382

6 June 2018

Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451382

6 June 2018

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis

1 reference

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6 June 2018

Cracking the phosphatase code: docking interactions determine substrate specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451382

6 June 2018

Serine/threonine phosphatases: mechanism through structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451382

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A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants

1 reference

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From promiscuity to precision: protein phosphatases get a makeover

1 reference

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Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development

1 reference

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Crystal Structures of Protein Phosphatase-1 Bound to Nodularin-R and Tautomycin: A Novel Scaffold for Structure-based Drug Design of Serine/Threonine Phosphatase Inhibitors

1 reference

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Detailed structural characterization of unbound protein phosphatase 1 inhibitors

1 reference

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Structural basis for regulation of protein phosphatase 1 by inhibitor-2

1 reference

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Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction

1 reference

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The role of Shp2 (PTPN11) in cancer.

1 reference

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6 June 2018

Protein tyrosine phosphatases: from genes, to function, to disease

1 reference

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Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins

1 reference

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A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

1 reference

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Protein tyrosine phosphatases and the immune response

1 reference

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Protein tyrosine phosphatases in the human genome

1 reference

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1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451382

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The protein kinase complement of the human genome

1 reference

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Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Combinatorial control of protein phosphatase-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/25771485

12 December 2020

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Identifiers

10.1016/J.BMC.2015.02.040

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

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