(Q41515960)

2 October 2017

1 reference

title

Hepatotoxicity in drug development: detection, significance and solutions (English)

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2 October 2017

1 reference

Ballet F

1

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2 October 2017

1 January 1997

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2 October 2017

Journal of Hepatology

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2 October 2017

26 Suppl 2

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2 October 2017

26-36

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New Applications of Microbial Products

2 October 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Natural plant chemicals: sources of industrial and medicinal materials

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Structure-based strategies for drug design and discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Safety assessment programs for U.S. regulatory agencies: a perspective of requirements and compliance

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Risks, regulation, and rewards in new drug development in the United States

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Predictive value of animal studies in toxicology

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

The use of the dog in toxicity tests on pharmaceutical compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

The concept of multispecies testing in industrial toxicology.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Correlation of metabolism, covalent binding and toxicity for a series of bromobenzene derivatives using rat liver slices in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

The integration of investigative toxicology in the drug discovery process

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

The role of experimental toxicology in safety evaluation: challenges facing the pharmaceutical industry

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Effect of bile acids on intracellular calcium in isolated rat hepatocyte couplets

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Effect of tauroursodeoxycholate on actin filament alteration induced by cholestatic agents. A study in isolated rat hepatocyte couplets

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Actin filament alteration as a potential marker for cholestasis: a study in isolated rat hepatocyte couplets

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Reactive intermediates and their toxicological significance

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Role of Covalent and Noncovalent Interactions in Cell Toxicity: Effects on Proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Specific targets of covalent drug-protein interactions in hepatocytes and their toxicological significance in drug-induced liver injury

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Immunochemical detection of liver protein adducts of the nonsteroidal antiinflammatory drug diclofenac

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Immunochemical detection of acetaminophen-bound liver proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Immunochemical analysis of acetaminophen covalent binding to proteins. Partial characterization of the major acetaminophen-binding liver proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity: comparison with two directly hepatotoxic drugs.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro. Studies with human and rat liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Preclinical evaluation of lovastatin

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Induction of liver growth by xenobiotic compounds and other stimuli.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Nuclear receptors and chemical carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

The dioxin and peroxisome proliferator-activated receptors: nuclear receptors in search of endogenous ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Carcinogenicity of TCDD: experimental, mechanistic, and epidemiologic evidence

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Growth stimulation followed by growth inhibition in livers of female rats treated with ethinyl estradiol

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Phenobarbital induction of cytochrome P-450 gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Mechanisms of non-genotoxic carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Current knowledge of mechanisms of carcinogenicity: genotoxins versus non-genotoxins

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Cell death by apoptosis and its protective role against disease

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Concepts, labeling procedures, and design of cell proliferation studies relating to carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Peroxisome proliferation and nongenotoxic carcinogenesis: commentary on a symposium

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Biochemical mechanisms of induction of hepatic peroxisome proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

The significance of hepatic microsomal enzyme induction and altered thyroid function in rats: implications for thyroid gland neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

UDP-glucuronosyltransferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Comparison of proliferating cell nuclear antigen to tritiated thymidine as a marker of proliferating hepatocytes in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Retrospective assessment of liver cell proliferation via PCNA: a comparison with tritiated thymidine

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Image analysis of bromodeoxyuridine (BrdU) staining for measurement of S-phase in rat and mouse liver

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

Use of cell proliferation data in cancer risk assessment: FDA view

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2980494-1

7 January 2021

10.1016/S0168-8278(97)80494-1

Identifiers

DOI

1 reference

2 October 2017

1 reference

PubMed ID

9204407