(Q41545564)

3 October 2017

Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3. (English)

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3 October 2017

8

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3 October 2017

9

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3 October 2017

Miklós Kovács

4

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Zoltán Jakus

object named as

Zoltán Jakus

3

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Leonard R. Stephens

object named as

Len Stephens

7

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Phillip Thomas Hawkins

object named as

Phillip T Hawkins

6

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author name string

Laure Gambardella

1

1 reference

3 October 2017

Karen E Anderson

2

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3 October 2017

Susann Voigt

5

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3 October 2017

language of work or name

English

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publication date

23 November 2012

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3 October 2017

Journal of Immunology

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3 October 2017

190

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3 October 2017

1

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3 October 2017

381-391

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describes a project that uses

3 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3672969/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease

6 June 2018

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Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling

6 June 2018

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Regulation of human neutrophil Fcγ receptor IIa by C5a receptor promotes inflammatory arthritis in mice

6 June 2018

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PI3K signaling in neutrophils

6 June 2018

1 reference

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Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.

6 June 2018

1 reference

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The ins and outs of leukocyte integrin signaling

6 June 2018

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Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis

6 June 2018

1 reference

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CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks

6 June 2018

1 reference

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Critical but overlapping role of FcgammaRIII and FcgammaRIV in activation of murine neutrophils by immobilized immune complexes

6 June 2018

1 reference

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Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins

6 June 2018

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Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1

6 June 2018

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Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

6 June 2018

1 reference

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Neutrophils and immunity: challenges and opportunities

6 June 2018

1 reference

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P-Rex1 regulates neutrophil function

6 June 2018

1 reference

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FcgammaRIV: a novel FcR with distinct IgG subclass specificity

6 June 2018

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Importance of integrin LFA-1 deactivation for the generation of immune responses

6 June 2018

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Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672969

Rap1b is required for normal platelet function and hemostasis in mice

6 June 2018

1 reference

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An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients

6 June 2018

1 reference

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Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672969

Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672969

Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase

6 June 2018

1 reference

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From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins

6 June 2018

1 reference

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Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice

6 June 2018

1 reference

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CR3 (Mac-1, alpha M beta 2, CD11b/CD18) and Fc gamma RIII cooperate in generation of a neutrophil respiratory burst: requirement for Fc gamma RIII and tyrosine phosphorylation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672969

Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672969

PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672969

PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672969

Integrin regulation by RhoA in thymocytes

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672969

Responses of neutrophils to anti-integrin antibodies depends on costimulation through low affinity Fc gamma Rs: full activation requires both integrin and nonintegrin signals

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672969

RhoA and zeta PKC control distinct modalities of LFA-1 activation by chemokines: critical role of LFA-1 affinity triggering in lymphocyte in vivo homing

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672969

Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672969

Down-regulation of Rac activity during beta 2 integrin-mediated adhesion of human neutrophils

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672969

Syk is required for integrin signaling in neutrophils

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672969

ARAP3 is a PI3K- and rap-regulated GAP for RhoA

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672969

PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis

4 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672969

Manifestations of inflammatory arthritis are critically dependent on LFA-1

2 December 2018

1 reference

12 December 2020

ARAP3 binding to phosphatidylinositol-(3,4,5)-trisphosphate depends on N-terminal tandem PH domains and adjacent sequences

1 reference

12 December 2020

Vav proteins in neutrophils are required for FcgammaR-mediated signaling to Rac GTPases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox)

1 reference

12 December 2020

The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils

1 reference

12 December 2020

Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow

1 reference

12 December 2020

Cocapping of the leukoadhesin molecules complement receptor type 3 and lymphocyte function-associated antigen-1 with Fc gamma receptor III on human neutrophils. Possible role of lectin-like interactions

1 reference

12 December 2020

Role of Rho in chemoattractant-activated leukocyte adhesion through integrins

1 reference

12 December 2020

Organ-specific disease provoked by systemic autoimmunity

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1201330

1 reference

3 October 2017

1 reference

3 October 2017

PubMed publication ID

23180820

1 reference