(Q41680681)

English

Curcumin protects rat liver from streptozotocin-induced diabetic pathophysiology by counteracting reactive oxygen species and inhibiting the activation of p53 and MAPKs mediated stress response pathways

scientific article published on 2 January 2015

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scholarly article

1 reference

Europe PubMed Central

7 October 2017

Curcumin protects rat liver from streptozotocin-induced diabetic pathophysiology by counteracting reactive oxygen species and inhibiting the activation of p53 and MAPKs mediated stress response pathways (English)

1 reference

Europe PubMed Central

7 October 2017

0 references

reactive oxygen species

1 reference

based on heuristic

inferred from title

author name string

Shatadal Ghosh

1

1 reference

Europe PubMed Central

7 October 2017

Sudip Bhattacharyya

2

1 reference

Europe PubMed Central

7 October 2017

Kahkashan Rashid

3

1 reference

Europe PubMed Central

7 October 2017

Parames C Sil

4

1 reference

Europe PubMed Central

7 October 2017

publication date

2 January 2015

1 reference

Europe PubMed Central

7 October 2017

Toxicology reports

1 reference

Europe PubMed Central

7 October 2017

2

1 reference

Europe PubMed Central

7 October 2017

365-376

1 reference

Europe PubMed Central

7 October 2017

p53 activation and mitochondria-mediated pathway are involved during hanging death-induced neuronal cell apoptosis in dentate gyrus region of the rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Transforming growth factor-β-induced cross talk between p53 and a microRNA in the pathogenesis of diabetic nephropathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Therapeutic roles of curcumin: lessons learned from clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Regulation of GAD65 expression by SMAR1 and p53 upon Streptozotocin treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Mechanism of the protective action of taurine in toxin and drug induced organ pathophysiology and diabetic complications: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Effect of novel water soluble curcumin derivative on experimental type- 1 diabetes mellitus (short term study)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Multitargeting by curcumin as revealed by molecular interaction studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Curcumin treatment suppresses IKKβ kinase activity of salivary cells of patients with head and neck cancer: a pilot study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Oxidative stress and diabetic complications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Curcumin attenuates the effects of insulin on stimulating hepatic stellate cell activation by interrupting insulin signaling and attenuating oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Phase II trial of curcumin in patients with advanced pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Bioavailability of curcumin: problems and promises

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Animal models in type 2 diabetes research: an overview.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Formulation and characterization of curcuminoids loaded solid lipid nanoparticles.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Differential effect of saturated, monounsaturated, and polyunsaturated fatty acids on alloxan-induced diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Curcumin therapy in inflammatory bowel disease: a pilot study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Mitochondrial activation of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Tissue sulfhydryl groups

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Diabetes, oxidative stress, and antioxidants: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Caspases: opening the boxes and interpreting the arrows

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Lipid peroxidation-DNA damage by malondialdehyde

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Human erythrocyte catalase: an improved method of isolation and a reevaluation of reported properties.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Glutathione S-transferases. The first enzymatic step in mercapturic acid formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Isolation of highly purified mitochondria from rat pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Assay of glutathione reductase in crude tissue homogenates using 5,5'-dithiobis(2-nitrobenzoic acid)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Glutathione metabolism and its selective modification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Antioxidant activity of curcumin and related compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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6 June 2018

Studies on Streptozotocin Diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

6 June 2018

Oxidative stress parameters in blood, liver, and kidney of diabetic rats treated with curcumin and/or insulin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

18 August 2018

The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

18 August 2018

Comparative and combined effect of chlorogenic acid and tetrahydrocurcumin on antioxidant disparities in chemical induced experimental diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

18 August 2018

Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

18 August 2018

Improvement in oxidative stress and antioxidant parameters in beta-thalassemia/Hb E patients treated with curcuminoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

18 August 2018

Protection of arsenic-induced testicular oxidative stress by arjunolic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

18 August 2018

Antihyperlipidemic effect of curcumin and tetrahydrocurcumin in experimental type 2 diabetic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

18 August 2018

Evidence for p53 as guardian of the cardiomyocyte mitochondrial genome following acute adriamycin treatment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

18 August 2018

Beneficial effects of the bioflavonoids curcumin and quercetin on early function in cadaveric renal transplantation: a randomized placebo controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

18 August 2018

Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

18 August 2018

Stable and functional regeneration of pancreatic beta-cell population in nSTZ-rats treated with tungstate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

18 August 2018

Insulin-like growth factor-1 prevents loss of electrochemical gradient in cardiac muscle mitochondria via activation of PI 3 kinase/Akt pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

18 August 2018

Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

18 August 2018

Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

18 August 2018

Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

18 August 2018

Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5598222

18 August 2018

Drug-induced suppression of phosphorylase kinase activity correlates with resolution of psoriasis as assessed by clinical, histological and immunohistochemical parameters

1 reference

https://pubmed.ncbi.nlm.nih.gov/28962370

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Curcumin, the active principle of turmeric (Curcuma longa), ameliorates diabetic nephropathy in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/28962370

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/28962370

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Effects of curcumin intake on kidney and liver pathological changes in T2DM rats]

1 reference

https://pubmed.ncbi.nlm.nih.gov/28962370

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes increases p53-mediated apoptosis following ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/28962370

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of cultured pancreatic B-cells with streptozotocin induces cell death by apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28962370

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Responses of Neonatal Rat Islets to Streptozotocin: Limited B-Cell Regeneration and Hyperglycemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/28962370

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibacterial Action of Curcumin and Related Compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/28962370

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/28962370

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration

1 reference

https://pubmed.ncbi.nlm.nih.gov/28962370

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 promotes cardiac dysfunction in diabetic mellitus caused by excessive mitochondrial respiration-mediated reactive oxygen species generation and lipid accumulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28962370

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical development plan: curcumin

1 reference

https://pubmed.ncbi.nlm.nih.gov/28962370

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal

1 reference

https://pubmed.ncbi.nlm.nih.gov/28962370

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A fluorometric method for determination of oxidized and reduced glutathione in tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/28962370

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Taurine ameliorates alloxan-induced diabetic renal injury, oxidative stress-related signaling pathways and apoptosis in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/28962370

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Taurine protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28962370

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assays of glutathione peroxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/28962370

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.TOXREP.2014.12.017

1 reference

Europe PubMed Central

7 October 2017

1 reference

Europe PubMed Central

7 October 2017

1 reference

Europe PubMed Central

7 October 2017

ResearchGate publication ID

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