(Q41689650)

7 October 2017

title

A mutant form of human protein farnesyltransferase exhibits increased resistance to farnesyltransferase inhibitors (English)

1 reference

7 October 2017

Del Villar K

1

1 reference

7 October 2017

Urano J

series ordinal

2

1 reference

7 October 2017

Guo L

series ordinal

3

1 reference

7 October 2017

Tamanoi F

series ordinal

4

1 reference

7 October 2017

language of work or name

English

0 references

publication date

1 September 1999

1 reference

Journal of Biological Chemistry

7 October 2017

published in

1 reference

7 October 2017

volume

274

1 reference

7 October 2017

issue

38

1 reference

7 October 2017

page(s)

27010-27017

1 reference

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

7 October 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Protein prenylation: molecular mechanisms and functional consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Protein farnesyltransferase: structure and implications for substrate binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Mutant farnesyltransferase beta subunit of Saccharomyces cerevisiae that can substitute for geranylgeranyltransferase type I beta subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Amino acid substitutions that convert the protein substrate specificity of farnesyltransferase to that of geranylgeranyltransferase type I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Farnesyltransferase inhibitors induce dramatic morphological changes of KNRK cells that are blocked by microtubule interfering agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Identification of Ras farnesyltransferase inhibitors by microbial screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Metal-chelating inhibitors of a zinc finger protein HIV-EP1. Remarkable potentiation of inhibitory activity by introduction of SH groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Improved method for high efficiency transformation of intact yeast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Synthetic inhibitors of regulatory proteins involved in the signaling pathway of the replication of human immunodeficiency virus 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Evidence for a catalytic role of zinc in protein farnesyltransferase. Spectroscopy of Co2+-farnesyltransferase indicates metal coordination of the substrate thiolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Mutational analysis of conserved residues of the beta-subunit of human farnesyl:protein transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Functional consequence of mutating conserved residues of the yeast farnesyl-protein transferase beta-subunit Ram1(Dpr1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Yeast protein farnesyltransferase. Site-directed mutagenesis of conserved residues in the beta-subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Amino acid residues that define both the isoprenoid and CAAX preferences of the Saccharomyces cerevisiae protein farnesyltransferase. Creating the perfect farnesyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

From bench top to bedside

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.38.27010

21 January 2018

Identifiers

DOI

10.1074/JBC.274.38.27010

1 reference

release_vlvjwdw7sffj3dufhebzahrr74

7 October 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/vlvjwdw7sffj3dufhebzahrr74

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference