(Q41712081)

English

Pneumolysin activates macrophage lysosomal membrane permeabilization and executes apoptosis by distinct mechanisms without membrane pore formation

scientific article published on 7 October 2014

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scholarly article

1 reference

Europe PubMed Central

7 October 2017

Pneumolysin activates macrophage lysosomal membrane permeabilization and executes apoptosis by distinct mechanisms without membrane pore formation (English)

1 reference

Europe PubMed Central

7 October 2017

Andrea Mitchell

object named as

Andrea Mitchell

4

0 references

Helen M Marriott

object named as

Helen M Marriott

6

0 references

object named as

Robert C Read

7

0 references

Timothy J Mitchell

object named as

Timothy J Mitchell

8

0 references

Moira K B Whyte

9

object named as

Moira K B Whyte

1 reference

Europe PubMed Central

7 October 2017

author name string

Martin A Bewley

1

1 reference

Europe PubMed Central

7 October 2017

Michael Naughton

2

1 reference

Europe PubMed Central

7 October 2017

Julie Preston

3

1 reference

Europe PubMed Central

7 October 2017

Ashleigh Holmes

5

1 reference

Europe PubMed Central

7 October 2017

David H Dockrell

10

1 reference

Europe PubMed Central

7 October 2017

publication date

7 October 2014

1 reference

Europe PubMed Central

7 October 2017

1 reference

Europe PubMed Central

7 October 2017

5

1 reference

Europe PubMed Central

7 October 2017

5

1 reference

Europe PubMed Central

7 October 2017

e01710-14

1 reference

Europe PubMed Central

7 October 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4196231/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection

1 reference

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1 reference

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1 reference

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Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection.

1 reference

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Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae

1 reference

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RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein

1 reference

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A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.

1 reference

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Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.

1 reference

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1 reference

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Regulation of apoptosis-associated lysosomal membrane permeabilization

1 reference

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Streptococcus pneumoniae evades human dendritic cell surveillance by pneumolysin expression

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1 reference

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Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells

1 reference

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Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor

1 reference

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A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome

1 reference

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1 reference

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Pneumolysin: a double-edged sword during the host-pathogen interaction

1 reference

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

1 reference

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The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease

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6 June 2018

Tumor suppressor cylindromatosis acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling

1 reference

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6 June 2018

Pneumolysin causes neuronal cell death through mitochondrial damage

1 reference

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Autophagy, ageing and apoptosis: the role of oxidative stress and lysosomal iron

1 reference

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6 June 2018

Identification of a secreted cholesterol-dependent cytolysin (mitilysin) from Streptococcus mitis

1 reference

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Epithelial cells are sensitive detectors of bacterial pore-forming toxins

1 reference

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Identification of invasive serotype 1 pneumococcal isolates that express nonhemolytic pneumolysin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196231

6 June 2018

Streptococcus pneumoniae : Epidemiology, Risk Factors, and Clinical Features

1 reference

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6 June 2018

The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease

1 reference

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Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopolysaccharide-stimulated macrophages

1 reference

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6 June 2018

Structural basis of pore formation by the bacterial toxin pneumolysin

1 reference

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Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance

1 reference

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Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium

1 reference

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Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae

1 reference

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6 June 2018

CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection.

1 reference

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Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense

1 reference

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6 June 2018

Geographic distribution and clonal diversity of Streptococcus pneumoniae serotype 1 isolates.

1 reference

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6 June 2018

Toll-like receptors in health and disease: complex questions remain.

1 reference

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6 June 2018

Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection

1 reference

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6 June 2018

Pneumococcal infections in humans are associated with increased apoptosis and trafficking of type 1 cytokine-producing T cells

1 reference

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6 June 2018

Pore-forming toxins

1 reference

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6 June 2018

Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis

1 reference

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6 June 2018

Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196231

6 June 2018

Essential role of domain 4 of pneumolysin from Streptococcus pneumoniae in cytolytic activity as determined by truncated proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196231

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Cytolysin-mediated translocation (CMT): a functional equivalent of type III secretion in gram-positive bacteria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196231

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Pathogenesis of pneumococcal infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196231

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Cholesterol-binding cytolytic protein toxins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196231

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Intracellular trafficking and killing of Streptococcus pneumoniae by human alveolar macrophages are influenced by opsonins

1 reference

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The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196231

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Molecular analysis of virulence factors of Streptococcus pneumoniae

1 reference

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Relationship between phagosome acidification, phagosome-lysosome fusion, and mechanism of particle ingestion.

1 reference

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Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes.

1 reference

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Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia

1 reference

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Diphtheria toxin fragment forms large pores in phospholipid bilayer membranes

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Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae

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1 reference

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Accumulation of indigestible substances reduces fusion competence of macrophage lysosomes

1 reference

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Macrophage heterogeneity occurs through a developmental mechanism

1 reference

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Cytochalasin inhibits the rate of elongation of actin filament fragments

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Myeloid differentiation factor 88-dependent signalling controls bacterial growth during colonization and systemic pneumococcal disease in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196231

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The mechanism of pneumolysin-induced cochlear hair cell death in the rat.

1 reference

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Additive inhibition of complement deposition by pneumolysin and PspA facilitates Streptococcus pneumoniae septicemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196231

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Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor

1 reference

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Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection.

1 reference

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Alveolar Macrophage Apoptosis Contributes to Pneumococcal Clearance in a Resolving Model of Pulmonary Infection

1 reference

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18 August 2018

Streptococcus pneumoniae-associated human macrophage apoptosis after bacterial internalization via complement and Fcgamma receptors correlates with intracellular bacterial load.

1 reference

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Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis

1 reference

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Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia

1 reference

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18 August 2018

Immune-mediated phagocytosis and killing of Streptococcus pneumoniae are associated with direct and bystander macrophage apoptosis.

1 reference

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The NLRP3 Inflammasome Is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia

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Mechanism of apoptosis induced by a lysosomotropic agent, L-Leucyl-L-Leucine methyl ester

1 reference

https://pubmed.ncbi.nlm.nih.gov/25293758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative inactivation of pneumolysin by the myeloperoxidase system and stimulated human neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/25293758

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based on heuristic

inferred from PubMed ID database lookup

Degranulation and enzyme release during phagocytosis of inert particles and of bacteria by polymorphonuclear neutrophil granulocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25293758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/25293758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/25293758

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MBIO.01710-14

1 reference

Europe PubMed Central

7 October 2017

1 reference

Europe PubMed Central

7 October 2017

1 reference

Europe PubMed Central

7 October 2017

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