(Q41716371)

English

mTOR kinase-dependent, but raptor-independent regulation of downstream signaling is important for cell cycle exit and myogenic differentiation

scientific article published on January 2014

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

mTOR kinase-dependent, but raptor-independent regulation of downstream signaling is important for cell cycle exit and myogenic differentiation (English)

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

author name string

Hilary J Pollard

1

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

Mark Willett

2

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

Simon J Morley

3

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

publication date

1 January 2014

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

13

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

16

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

2517-2525

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase

1 reference

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mTOR signaling in growth control and disease

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mTOR-independent 4E-BP1 phosphorylation is associated with cancer resistance to mTOR kinase inhibitors

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High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1.

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Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy.

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Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence

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mTOR: from growth signal integration to cancer, diabetes and ageing

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mTORC1 signaling: what we still don't know

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PRAS40 regulates protein synthesis and cell cycle in C2C12 myoblasts

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The translation regulatory subunit eIF3f controls the kinase-dependent mTOR signaling required for muscle differentiation and hypertrophy in mouse

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The mTORC2 complex regulates terminal differentiation of C2C12 myoblasts

1 reference

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Inhibition of mammalian target of rapamycin (mTOR) signalling in C2C12 myoblasts prevents myogenic differentiation without affecting the hyperphosphorylation of 4E-BP1.

1 reference

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Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

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6 June 2018

Molecular mechanisms of mTOR-mediated translational control

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Regulation of translation initiation in eukaryotes: mechanisms and biological targets

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Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

1 reference

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6 June 2018

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

1 reference

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6 June 2018

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

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Defining the role of mTOR in cancer

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

1 reference

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

1 reference

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Specific isoforms of translation initiation factor 4GI show differences in translational activity

1 reference

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

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mTOR pathway inhibition attenuates skeletal muscle growth induced by stretching

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mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

1 reference

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Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade.

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Mammalian target of rapamycin (mTOR) signaling is required for a late-stage fusion process during skeletal myotube maturation

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Initiation factor modifications in the preapoptotic phase

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

1 reference

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The proteasome inhibitor, MG132, promotes the reprogramming of translation in C2C12 myoblasts and facilitates the association of hsp25 with the eIF4F complex

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.

1 reference

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Skeletal myocyte hypertrophy requires mTOR kinase activity and S6K1.

1 reference

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Molecular cross-talk between MEK1/2 and mTOR signaling during recovery of 293 cells from hypertonic stress

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18 August 2018

Identifiers

10.4161/15384101.2014.941747

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

ResearchGate publication ID

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