(Q41756842)

8 October 2017

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title

Metabolism of the newer antidepressants. An overview of the pharmacological and pharmacokinetic implications (English)

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8 October 2017

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Caccia S

1

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8 October 2017

1 April 1998

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Clinical Pharmacokinetics

8 October 2017

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8 October 2017

34

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8 October 2017

281-302

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8 October 2017

4

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https://scigraph.springernature.com/pub.10.2165/00003088-199834040-00002

8 October 2017

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12 December 2020

Phenacetin O-deethylation by human liver microsomes in vitro: inhibition by chemical probes, SSRI antidepressants, nefazodone and venlafaxine

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Fluvoxamine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness

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Antidepressants. A comparative review of the clinical pharmacology and therapeutic use of the 'newer' versus the 'older' drugs

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12 December 2020

Cytochrome P450 enzymes: interpretation of their interactions with selective serotonin reuptake inhibitors. Part II.

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12 December 2020

Daily administration of m-chlorophenylpiperazine to healthy human volunteers rapidly attenuates many of its behavioral, hormonal, cardiovascular and temperature effects.

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Venlafaxine oxidation in vitro is catalysed by CYP2D6.

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12 December 2020

Active hydroxymetabolites of antidepressants. Emphasis on E-10-hydroxy-nortriptyline

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12 December 2020

Pharmacokinetics of sertraline and its N-demethyl metabolite in elderly and young male and female volunteers.

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12 December 2020

Effects of the (+) and (-) enantiomers of the antidepressant drug tianeptine on 5-HTP-induced behaviour

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12 December 2020

The clinical application of tricyclic antidepressant pharmacokinetics and plasma levels

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12 December 2020

Mirtazapine: pharmacology in relation to adverse effects

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12 December 2020

Antidepressants, metabolites, and apparent drug resistance

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12 December 2020

Sertraline. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depression and obsessive-compulsive disorder

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12 December 2020

The disposition of fluoxetine but not sertraline is altered in poor metabolizers of debrisoquin

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12 December 2020

The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes

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12 December 2020

Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants

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12 December 2020

Pharmacokinetics of reboxetine in healthy volunteers. Single against repeated oral doses and lack of enzymatic alterations

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12 December 2020

Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain.

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12 December 2020

Clinical pharmacokinetics of the monoamine oxidase-A inhibitor moclobemide

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12 December 2020

Species-specific biotransformation of moclobemide: a comparative study in rats and humans.

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12 December 2020

Inhibition by paroxetine of desipramine metabolism in extensive but not in poor metabolizers of sparteine

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12 December 2020

Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration

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12 December 2020

Pharmacokinetic and pharmacodynamic drug interactions with polypharmacotherapy of treatment-resistant affective and obsessive-compulsive disorders.

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12 December 2020

Clinical pharmacokinetics of nefazodone

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12 December 2020

A review of the metabolism and pharmacokinetics of paroxetine in man.

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12 December 2020

Biotransformation of moclobemide in humans

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12 December 2020

Single and multiple dose pharmacokinetics of nefazodone in subjects classified as extensive and poor metabolizers of dextromethorphan

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12 December 2020

The emerging role of cytochrome P450 3A in psychopharmacology

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12 December 2020

A review of functional neuroimaging in mood disorders: positron emission tomography and depression

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12 December 2020

Comparison of the effects of sertraline and its metabolite desmethylsertraline on blockade of central 5-HT reuptake in vivo.

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12 December 2020

The Role of Metabolites of Antidepressants in the Treatment of Depression

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12 December 2020

Therapeutic monitoring of antidepressant drugs: guidelines updated

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12 December 2020

Inhibition of cytochrome P450 by nefazodone in vitro: studies of dextromethorphan O- and N-demethylation

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12 December 2020

A double-blind, placebo-controlled study of citalopram with and without lithium in the treatment of therapy-resistant depressive patients: a clinical, pharmacokinetic, and pharmacogenetic investigation

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12 December 2020

Metabolism and disposition of the 5-hydroxytryptamine uptake blocker sertraline in the rat and dog.

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12 December 2020

The disposition of venlafaxine enantiomers in dogs, rats, and humans receiving venlafaxine

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12 December 2020

A study of the effect of age and gender on the pharmacokinetics of nefazodone after single and multiple doses

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12 December 2020

Pharmacokinetic and pharmacodynamic significance of antidepressant drug metabolites

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12 December 2020

Inhibition of antidepressant demethylation and hydroxylation by fluvoxamine in depressed patients

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12 December 2020

The role of beta-glucuronidase in drug disposition and drug targeting in humans

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12 December 2020

Review of the animal pharmacology and pharmacokinetics of fluvoxamine

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12 December 2020

Progress report on the anorectic effects of dexfenfluramine, fluoxetine and sertraline

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12 December 2020

Paroxetine potentiates the central nervous system side effects of perphenazine: contribution of cytochrome P4502D6 inhibition in vivo.

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12 December 2020

Absorption and disposition of moclobemide in patients with advanced age or reduced liver or kidney function

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12 December 2020

Stereoselective and species-dependent kinetics of reboxetine in mouse and rat

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12 December 2020

Drug-drug interactions involving antidepressants: focus on venlafaxine

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12 December 2020

Disposition kinetics of moclobemide, a monoamine oxidase-A enzyme inhibitor: single and multiple dosing in normal subjects

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12 December 2020

Mirtazapine : A Review of its Pharmacology and Therapeutic Potential in the Management of Major Depression

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12 December 2020

Moclobemide treatment causes a substantial rise in the sparteine metabolic ratio. Danish University Antidepressant Group

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12 December 2020

The relationship between paroxetine and the sparteine oxidation polymorphism

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12 December 2020

Inhibition by fluoxetine of cytochrome P450 2D6 activity.

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12 December 2020

Importance of duration of drug action in the antagonism of p-chloroamphetamine depletion of brain serotonin—comparison of fluoxetine and chlorimipramine

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12 December 2020

Moclobemide. A review of its pharmacological properties and therapeutic use in depressive illness

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12 December 2020

Pharmacokinetic and pharmacodynamic evaluation of the potential drug interaction between venlafaxine and diazepam.

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12 December 2020

Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative

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12 December 2020

Inhibitors of imipramine metabolism by human liver microsomes

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12 December 2020

Analysis of enantiomers of citalopram and its demethylated metabolites in plasma of depressive patients using chiral reverse-phase liquid chromatography

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12 December 2020

Tianeptine and its main metabolite. Disposition in chronic renal failure and haemodialysis

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12 December 2020

1-Aryl-2-(aminomethyl)cyclopropanecarboxylic acid derivatives. A new series of potential antidepressants

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12 December 2020

Fluvoxamine inhibits the CYP2C19-catalyzed bioactivation of chloroguanide*

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12 December 2020

Tianeptine and its main metabolite pharmacokinetics in chronic alcoholism and cirrhosis

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12 December 2020

Pharmacokinetics of antidepressants: why and how they are relevant to treatment

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12 December 2020

Selective serotonin reuptake inhibitors and CNS drug interactions. A critical review of the evidence

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12 December 2020

Citalopram. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness

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12 December 2020

Plasma concentrations of trazodone and 1-(3-chlorophenyl)piperazine in man after a single oral dose of trazodone

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12 December 2020

Effects of short- and long-term administration of fluoxetine on the monoamine content of rat brain

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12 December 2020

The alpha 2-adrenoceptor antagonist activity of ipsapirone and gepirone is mediated by their common metabolite 1-(2-pyrimidinyl)-piperazine (PmP)

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12 December 2020

The effect of renal disease on the disposition of venlafaxine

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12 December 2020

Disposition kinetics of moclobemide, a new MAO-A inhibitor, in subjects with impaired renal function

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12 December 2020

Desipramine pharmacokinetics when coadministered with paroxetine or sertraline in extensive metabolizers

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12 December 2020

Steady-state pharmacokinetics of nefazodone in subjects with normal and impaired renal function

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12 December 2020

Inhibition of trazodone metabolism by thioridazine in humans

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12 December 2020

Therapeutic drug monitoring of tricyclic antidepressants

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12 December 2020

Are pharmacokinetic drug interactions with the SSRIs an issue?

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12 December 2020

Current antidepressants

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12 December 2020

The metabolic pathways of tianeptine, a new antidepressant, in healthy volunteers

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12 December 2020

Sertraline does not inhibit cytochrome P450 3A-mediated drug metabolism in vivo

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12 December 2020

Detection of psychoactive drugs using 19F MR spectroscopy

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12 December 2020

Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, org 3770 and its enantiomers

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12 December 2020

The effect of sertraline on the pharmacokinetics of desipramine and imipramine

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12 December 2020

Identification of cytochrome P450 isoforms involved in citalopram N-demethylation by human liver microsomes

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12 December 2020

Pharmacokinetics of milnacipran in comparison with other antidepressants

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12 December 2020

Single-dose pharmacokinetics of nefazodone in healthy young and elderly subjects and in subjects with renal or hepatic impairment

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12 December 2020

Inhibition of hepatic P-450 isoenzymes by serotonin selective reuptake inhibitors: in vitro and in vivo findings and their implications for patient care

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12 December 2020

Comparison of the disposition and of the metabolic pattern of Reboxetine, a new antidepressant, in the rat, dog, monkey and man.

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12 December 2020

Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression

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12 December 2020

Clinical pharmacokinetics of fluoxetine

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12 December 2020

Clinical Pharmacokinetics of Oral Buspirone in Patients with Impaired Renal Function

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12 December 2020

Tianeptine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depression and coexisting anxiety and depression

1 reference

12 December 2020

Clinically relevant pharmacology of selective serotonin reuptake inhibitors. An overview with emphasis on pharmacokinetics and effects on oxidative drug metabolism

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12 December 2020

Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms

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12 December 2020

Single- and multiple-dose pharmacokinetics of nefazodone in patients with hepatic cirrhosis

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12 December 2020

Kinetic profiles of tianeptine and its MC5 metabolite in plasma, blood and brain after single and chronic intraperitoneal administration in the rat.

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12 December 2020

Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors

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12 December 2020

Paroxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness

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12 December 2020

Selective serotonin reuptake inhibitors in older patients. A tolerability perspective

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12 December 2020

Venlafaxine: a structurally unique and novel antidepressant.

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12 December 2020

Anorectic activity of fluoxetine and norfluoxetine in mice, rats and guinea-pigs

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12 December 2020

Effect of cigarette smoking on fluvoxamine pharmacokinetics in humans

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12 December 2020

Review of the pharmacokinetics and metabolism of reboxetine, a selective noradrenaline reuptake inhibitor

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12 December 2020

Simultaneous determination of fluoxetine and norfluoxetine enantiomers in biological samples by gas chromatography with electron-capture detection

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12 December 2020

Serotonin reuptake blockers in vitro and in vivo.

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12 December 2020

Clinical pharmacokinetics 1990.

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12 December 2020

Neurochemical profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type A.

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12 December 2020

Formation of active metabolites of psychotropic drugs. An updated review of their significance

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12 December 2020

Venlafaxine: in vitro inhibition of CYP2D6 dependent imipramine and desipramine metabolism; comparative studies with selected SSRIs, and effects on human hepatic CYP3A4, CYP2C9 and CYP1A2.

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12 December 2020

Pharmacokinetic drug interaction potential of selective serotonin reuptake inhibitors.

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12 December 2020

Pharmacokinetics of reboxetine in healthy volunteers. Single oral doses, linearity and plasma protein binding

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12 December 2020

Moclobemide. An update of its pharmacological properties and therapeutic use

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12 December 2020

1-(m-chlorophenyl)piperazine (mCPP) interactions with neurotransmitter receptors in the human brain.

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12 December 2020

Comparison of desmethylsertraline with sertraline as a monoamine uptake inhibitor in vivo

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12 December 2020

Pharmacokinetic optimisation of therapy with newer antidepressants

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12 December 2020

Influence of the CYP1A2 inhibitor fluvoxamine on tacrine pharmacokinetics in humans

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12 December 2020

Neurobiology of tianeptine. A new pharmaceutic agent

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12 December 2020

Metabolic activation of the new tricyclic antidepressant tianeptine by human liver cytochrome P450

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12 December 2020

Non-response to citalopram in depressive patients: pharmacokinetic and clinical consequences of a fluvoxamine augmentation

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12 December 2020

Plasma moclobemide and metabolites: lack of correlation with clinical response and biogenic amines

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12 December 2020

Antidepressive action, pharmacokinetic characteristics and biochemical properties of cimoxatone, a new reversible MAO-A inhibitor

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12 December 2020

Metabolic disposition of 14C-venlafaxine in mouse, rat, dog, rhesus monkey and man

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12 December 2020

Non-linear fluvoxamine disposition

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12 December 2020

Plasma levels of citalopram enantiomers and metabolites in elderly patients

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12 December 2020

The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes

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12 December 2020

Metabolism of three pharmacologically active drugs in isolated human and rat hepatocytes: analysis of interspecies variability and comparison with metabolism in vivo

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12 December 2020

Pharmacokinetics of the newer antidepressants: clinical relevance

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12 December 2020

Serotonin-selective arylpiperazines with neuroendocrine, behavioral, temperature, and cardiovascular effects in humans

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12 December 2020

Pharmacogenetics of antidepressants: clinical aspects

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12 December 2020

Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness

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12 December 2020

Pharmacokinetics of the antidepressant tianeptine at steady state in the elderly

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12 December 2020

Preclinical pharmacology of milnacipran

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12 December 2020

The effects of single and repeated anorectic doses of 5-hydroxytryptamine uptake inhibitors on indole levels in rat brain

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12 December 2020

Identification of three cytochrome P450 isozymes involved in N-demethylation of citalopram enantiomers in human liver microsomes.

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12 December 2020

Second generation antidepressants: a comparative review

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12 December 2020

Antidepressants and drug-metabolizing enzymes--expert group report

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12 December 2020

Pharmacological antidepressive effects and tianeptine-induced 5-HT uptake increase.

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12 December 2020

Drug treatment of depression in the 1990s. An overview of achievements and future possibilities

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12 December 2020

Characterization of the metabolites of the antidepressant drug nefazodone in human urine and plasma

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12 December 2020

Clinically Relevant Pharmacology of Selective Serotonin Reuptake Inhibitors

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12 December 2020

10.2165/00003088-199834040-00002

Identifiers

DOI

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PubMed ID

9571301

Dimensions Publication ID

8 October 2017

0 references

1 reference

PubMed ID

9571301