(Q41757269)

English

Random mutagenesis of the multidrug transporter AcrB from Escherichia coli for identification of putative target residues of efflux pump inhibitors

scientific article published on 2 September 2014

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

8 October 2017

Random mutagenesis of the multidrug transporter AcrB from Escherichia coli for identification of putative target residues of efflux pump inhibitors (English)

1 reference

Europe PubMed Central

PMC publication ID

8 October 2017

Escherichia coli

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Escherichia coli

1 reference

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inferred from title

author name string

Sabine Schuster

1

1 reference

Europe PubMed Central

PMC publication ID

8 October 2017

Samay Kohler

2

1 reference

Europe PubMed Central

PMC publication ID

8 October 2017

Annika Buck

3

1 reference

Europe PubMed Central

PMC publication ID

8 October 2017

Christine Dambacher

4

1 reference

Europe PubMed Central

PMC publication ID

8 October 2017

Armin König

5

1 reference

Europe PubMed Central

PMC publication ID

8 October 2017

Jürgen A Bohnert

6

1 reference

Europe PubMed Central

PMC publication ID

8 October 2017

Winfried V Kern

7

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Europe PubMed Central

PMC publication ID

8 October 2017

language of work or name

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publication date

2 September 2014

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Europe PubMed Central

PMC publication ID

8 October 2017

number of pages

9

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Antimicrobial Agents and Chemotherapy

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Europe PubMed Central

PMC publication ID

8 October 2017

58

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Europe PubMed Central

PMC publication ID

8 October 2017

11

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Europe PubMed Central

PMC publication ID

8 October 2017

6870-6878

1 reference

Europe PubMed Central

PMC publication ID

8 October 2017

Structural basis for the inhibition of bacterial multidrug exporters

1 reference

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PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells

1 reference

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6 June 2018

Crystal structure of AcrB complexed with linezolid at 3.5 Å resolution

1 reference

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6 June 2018

The efflux inhibitor phenylalanine-arginine beta-naphthylamide (PAβN) permeabilizes the outer membrane of gram-negative bacteria

1 reference

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6 June 2018

CDD: conserved domains and protein three-dimensional structure

1 reference

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6 June 2018

Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations.

1 reference

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6 June 2018

Protein engineering methods applied to membrane protein targets

1 reference

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6 June 2018

Culture history and population heterogeneity as determinants of bacterial adaptation: the adaptomics of a single environmental transition

1 reference

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6 June 2018

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

1 reference

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6 June 2018

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

1 reference

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6 June 2018

Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria

1 reference

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6 June 2018

Determination of real-time efflux phenotypes in Escherichia coli AcrB binding pocket phenylalanine mutants using a 1,2'-dinaphthylamine efflux assay

1 reference

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6 June 2018

Random mutagenesis of the prokaryotic peptide transporter YdgR identifies potential periplasmic gating residues

1 reference

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6 June 2018

Substrate path in the AcrB multidrug efflux pump of Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249408

6 June 2018

Functional rotation of the transporter AcrB: insights into drug extrusion from simulations

1 reference

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6 June 2018

Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli

1 reference

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6 June 2018

Directed evolution reveals hidden properties of VMAT, a neurotransmitter transporter

1 reference

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6 June 2018

Directed evolution drives the next generation of biocatalysts

1 reference

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6 June 2018

Crucial role of Asp408 in the proton translocation pathway of multidrug transporter AcrB: evidence from site-directed mutagenesis and carbodiimide labeling

1 reference

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6 June 2018

Drug transport mechanism of the AcrB efflux pump

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249408

6 June 2018

Site-directed mutagenesis reveals putative substrate binding residues in the Escherichia coli RND efflux pump AcrB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249408

6 June 2018

Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities

1 reference

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6 June 2018

Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors

1 reference

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6 June 2018

A "silent" polymorphism in the MDR1 gene changes substrate specificity

1 reference

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6 June 2018

Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway

1 reference

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6 June 2018

Intracellular accumulation of linezolid in Escherichia coli, Citrobacter freundii and Enterobacter aerogenes: role of enhanced efflux pump activity and inactivation

1 reference

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6 June 2018

ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal

1 reference

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6 June 2018

Efflux-mediated antimicrobial resistance

1 reference

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6 June 2018

Selected arylpiperazines are capable of reversing multidrug resistance in Escherichia coli overexpressing RND efflux pumps

1 reference

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6 June 2018

Antibiotic-sensitive TolC mutants and their suppressors

1 reference

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6 June 2018

Chimeric analysis of the multicomponent multidrug efflux transporters from gram-negative bacteria.

1 reference

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6 June 2018

Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249408

6 June 2018

Crystal structure of bacterial multidrug efflux transporter AcrB

1 reference

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6 June 2018

Enhanced expression of the multidrug efflux pumps AcrAB and AcrEF associated with insertion element transposition in Escherichia coli mutants Selected with a fluoroquinolone

1 reference

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6 June 2018

Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy

1 reference

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6 June 2018

Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coli

1 reference

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6 June 2018

Drug uptake pathways of multidrug transporter AcrB studied by molecular simulations and site-directed mutagenesis experiments

1 reference

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18 August 2018

Effect of the F610A mutation on substrate extrusion in the AcrB transporter: explanation and rationale by molecular dynamics simulations.

1 reference

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18 August 2018

Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance

1 reference

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18 August 2018

Bacterial efflux pump inhibitors

1 reference

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18 August 2018

Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF).

1 reference

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18 August 2018

Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249408

18 August 2018

Crystal structures of a multidrug transporter reveal a functionally rotating mechanism.

1 reference

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18 August 2018

Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Escherichia coli

1 reference

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18 August 2018

Membrane topology of a multidrug efflux transporter, AcrB, in Escherichia coli

1 reference

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18 August 2018

A new and rapid method for monitoring the new oxazolidinone antibiotic linezolid in serum and urine by high performance liquid chromatography-integrated sample preparation

1 reference

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18 August 2018

Influence of the MexA-MexB-oprM multidrug efflux system on expression of the MexC-MexD-oprJ and MexE-MexF-oprN multidrug efflux systems in Pseudomonas aeruginosa.

1 reference

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18 August 2018

Identifiers

10.1128/AAC.03775-14

1 reference

Europe PubMed Central

PMC publication ID

8 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

8 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

8 October 2017

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