(Q41808908)

English

Mouse Model of Human Congenital Heart Disease: Progressive Atrioventricular Block Induced by a Heterozygous Nkx2-5 Homeodomain Missense Mutation

scientific article published on 30 July 2015

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scholarly article

1 reference

Europe PubMed Central

12 October 2017

Mouse Model of Human Congenital Heart Disease: Progressive Atrioventricular Block Induced by a Heterozygous Nkx2-5 Homeodomain Missense Mutation (English)

1 reference

Europe PubMed Central

12 October 2017

congenital disorder

0 references

atrioventricular block

1 reference

based on heuristic

inferred from title

congenital heart disease

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Rajib Chowdhury

1

1 reference

Europe PubMed Central

12 October 2017

Hassan Ashraf

2

1 reference

Europe PubMed Central

12 October 2017

Michelle Melanson

3

1 reference

Europe PubMed Central

12 October 2017

Yohei Tanada

4

1 reference

Europe PubMed Central

12 October 2017

Minh Nguyen

5

1 reference

Europe PubMed Central

12 October 2017

Michael Silberbach

6

1 reference

Europe PubMed Central

12 October 2017

Hiroko Wakimoto

7

1 reference

Europe PubMed Central

12 October 2017

D Woodrow Benson

8

1 reference

Europe PubMed Central

12 October 2017

Robert H Anderson

9

1 reference

Europe PubMed Central

12 October 2017

Hideko Kasahara

10

1 reference

Europe PubMed Central

12 October 2017

publication date

30 July 2015

1 reference

Europe PubMed Central

12 October 2017

Circulation: Arrhythmia and Electrophysiology

1 reference

Europe PubMed Central

12 October 2017

8

1 reference

Europe PubMed Central

12 October 2017

5

1 reference

Europe PubMed Central

12 October 2017

1255-1264

1 reference

Europe PubMed Central

12 October 2017

A mouse model of human congenital heart disease: high incidence of diverse cardiac anomalies and ventricular noncompaction produced by heterozygous Nkx2-5 homeodomain missense mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

The anatomy of the conduction system: implications for the clinical cardiologist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

Gene regulatory networks in cardiac conduction system development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

Novel NKX2-5 mutations responsible for congenital heart disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

Ectopic expression of Nkx2.5 suppresses the formation of the sinoatrial node in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

NKX2-5: an update on this hypermutable homeodomain protein and its role in human congenital heart disease (CHD).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

Biochemical analyses of eight NKX2.5 homeodomain missense mutations causing atrioventricular block and cardiac anomalies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

Development of the cardiac conduction system involves recruitment within a multipotent cardiomyogenic lineage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

The architecture of the atrioventricular conduction axis in dog compared to man: its significance to ablation of the atrioventricular nodal approaches.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

Distribution of acetylcholinesterase activity in the rat embryonic heart with reference to HNK-1 immunoreactivity in the conduction tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

6 June 2018

Novel NKX2-5 mutations in patients with familial atrial septal defects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

18 August 2018

Developmental origin, growth, and three-dimensional architecture of the atrioventricular conduction axis of the mouse heart.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

18 August 2018

Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

18 August 2018

Cardiac and extracardiac expression of Csx/Nkx2.5 homeodomain protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

18 August 2018

Familial transposition of the great arteries caused by multiple mutations in laterality genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618020

2 December 2018

Mutational spectrum in the cardiac transcription factor gene NKX2.5 (CSX) associated with congenital heart disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26226998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the cholinergic signal-transduction pathway components during embryonic rat heart development

1 reference

https://pubmed.ncbi.nlm.nih.gov/26226998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo cardiac electrophysiology studies in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/26226998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylcholinesterase in prenatal rat heart: a marker for the early development of the cardiac conductive tissue?

1 reference

https://pubmed.ncbi.nlm.nih.gov/26226998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmentally modulated cardiac conduction failure in transgenic mice with fetal or postnatal overexpression of DNA nonbinding mutant Nkx2.5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26226998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5

1 reference

https://pubmed.ncbi.nlm.nih.gov/26226998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1161/CIRCEP.115.002720

1 reference

Europe PubMed Central

12 October 2017

1 reference

Europe PubMed Central

12 October 2017

1 reference

Europe PubMed Central

12 October 2017

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