(Q42186727)

English

A mouse model of human congenital heart disease: high incidence of diverse cardiac anomalies and ventricular noncompaction produced by heterozygous Nkx2-5 homeodomain missense mutation

scientific article published on 15 July 2014

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scholarly article

1 reference

Europe PubMed Central

18 October 2017

A mouse model of human congenital heart disease: high incidence of diverse cardiac anomalies and ventricular noncompaction produced by heterozygous Nkx2-5 homeodomain missense mutation (English)

1 reference

Europe PubMed Central

18 October 2017

congenital disorder

0 references

congenital heart disease

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

object named as

Eileen I Chang

3

0 references

author name string

Hassan Ashraf

1

1 reference

Europe PubMed Central

18 October 2017

Lagnajeet Pradhan

2

1 reference

Europe PubMed Central

18 October 2017

Ryota Terada

4

1 reference

Europe PubMed Central

18 October 2017

Nicole J Ryan

5

1 reference

Europe PubMed Central

18 October 2017

Laura E Briggs

6

1 reference

Europe PubMed Central

18 October 2017

Rajib Chowdhury

7

1 reference

Europe PubMed Central

18 October 2017

Miguel A Zárate

8

1 reference

Europe PubMed Central

18 October 2017

Yukiko Sugi

9

1 reference

Europe PubMed Central

18 October 2017

Hyun-Joo Nam

10

1 reference

Europe PubMed Central

18 October 2017

D Woodrow Benson

11

1 reference

Europe PubMed Central

18 October 2017

Robert H Anderson

12

1 reference

Europe PubMed Central

18 October 2017

Hideko Kasahara

13

1 reference

Europe PubMed Central

18 October 2017

publication date

15 July 2014

1 reference

Europe PubMed Central

18 October 2017

Circulation: Cardiovascular Genetics

1 reference

Europe PubMed Central

18 October 2017

7

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Europe PubMed Central

18 October 2017

4

1 reference

Europe PubMed Central

18 October 2017

423-433

1 reference

Europe PubMed Central

18 October 2017

Nfatc1 directs the endocardial progenitor cells to make heart valve primordium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Crystal Structure of the Human NKX2.5 Homeodomain in Complex with DNA Target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Atrioventricular valve development: new perspectives on an old theme.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Progressive anatomical closure of foramen ovale in normal neonatal mouse hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Left ventricular noncompaction: a 25-year odyssey

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Differential role of Nkx2-5 in activation of the atrial natriuretic factor gene in the developing versus failing heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

The changing epidemiology of congenital heart disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

NKX2-5: an update on this hypermutable homeodomain protein and its role in human congenital heart disease (CHD).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Heterogeneity of genetic modifiers ensures normal cardiac development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Zac1 is an essential transcription factor for cardiac morphogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Genetic origins of pediatric heart disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Histology atlas of the developing mouse heart with emphasis on E11.5 to E18.5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

'Knock, and it shall be opened': knocking out and knocking in to reveal mechanisms of disease and novel therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Genetic factors in congenital heart malformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

The morphological spectrum of ventricular noncompaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Development and structure of the atrial septum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Echocardiographic and pathoanatomical characteristics of isolated left ventricular non-compaction: a step towards classification as a distinct cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Developmental patterning of the myocardium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Classification of ventricular septal defects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

26 October 2017

Novel NKX2-5 mutations responsible for congenital heart disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

29 May 2018

Biochemical analyses of eight NKX2.5 homeodomain missense mutations causing atrioventricular block and cardiac anomalies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

29 May 2018

Novel NKX2-5 mutations in patients with familial atrial septal defects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

17 August 2018

Congenital heart disease in live-born children: incidence, distribution, and yearly changes in the Campania Region.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

17 August 2018

Familial biventricular myocardial noncompaction associated with Ebstein's malformation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

17 August 2018

Haploinsufficiency of the cardiac transcription factor Nkx2-5 variably affects the expression of putative target genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

17 August 2018

Left heart lesions in patients with Ebstein anomaly.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

17 August 2018

Somatic NKX2-5 mutations as a novel mechanism of disease in complex congenital heart disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

17 August 2018

Lineage and morphogenetic analysis of the cardiac valves.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

17 August 2018

Prevalence of congenital heart disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

17 August 2018

Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

17 August 2018

Cardiac and extracardiac expression of Csx/Nkx2.5 homeodomain protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

17 August 2018

Formation of the tricuspid valve in the human heart.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

17 August 2018

Congenital Heart Defects in Europe: Prevalence and Perinatal Mortality, 2000 to 2005

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

1 December 2018

Familial transposition of the great arteries caused by multiple mutations in laterality genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140955

1 December 2018

Mutational spectrum in the cardiac transcription factor gene NKX2.5 (CSX) associated with congenital heart disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/25028484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5

1 reference

https://pubmed.ncbi.nlm.nih.gov/25028484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolated noncompaction of the ventricular myocardium: clinical and molecular aspects of a rare cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/25028484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25028484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ventricular septal defects

1 reference

https://pubmed.ncbi.nlm.nih.gov/25028484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stem cell and genetic therapies for the fetus

1 reference

https://pubmed.ncbi.nlm.nih.gov/25028484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1161/CIRCGENETICS.113.000281

1 reference

Europe PubMed Central

18 October 2017

1 reference

Europe PubMed Central

18 October 2017

1 reference

Europe PubMed Central

18 October 2017

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