(Q41814137)

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Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease

scientific article published on 8 February 2012

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22316420%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22316420%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

blood–brain barrier

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inferred from title

Henk-Jan Drenth

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22316420%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Elizabeth C de Lange

5

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22 January 2020

Meindert Danhof

4

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Meindert Danhof

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22 January 2020

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Paulien Gm Ravenstijn

1

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22 January 2020

Michael J O'Neill

3

1 reference

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22 January 2020

publication date

8 February 2012

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22316420%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Fluids and Barriers of the CNS

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22316420%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22316420%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22316420%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Structure and function of the blood-brain barrier

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Current status of symptomatic medical therapy in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson's disease, PSP and MSA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Motor complications in Parkinson disease: clinical manifestations and management

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Endothelial proliferation and increased blood-brain barrier permeability in the basal ganglia in a rat model of 3,4-dihydroxyphenyl-L-alanine-induced dyskinesia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Organic anion transporter family: current knowledge.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Pharmacokinetic optimisation in the treatment of Parkinson's disease : an update.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Protective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline against dopaminergic neurodegeneration in the extrapyramidal structures produced by intracerebral injection of rotenone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

The origin of motor fluctuations in Parkinson's disease: importance of dopaminergic innervation and basal ganglia circuits.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Parkinson's disease: mechanisms and models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Dopamine synthesis, uptake, metabolism, and receptors: relevance to gene therapy of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

On the origin of dopamine and its metabolite in predominantly noradrenergic innervated brain areas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Dopamine release in vivo from nigrostriatal, mesolimbic, and mesocortical neurons: utility of 3-methoxytyramine measurements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Homovanillic acid measurement in clinical research: a review of methodology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Assessment of dopamine and its metabolites in the intracellular and extracellular compartments of the rat striatum after peripheral administration of L-[11C]dopa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Characteristics of catechol O-methyl-transferase (COMT) and properties of selective COMT inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Biotransformation of L-dopa in striatum and substantia nigra of rats with a unilateral, nigrostriatal lesion: a microdialysis study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Levodopa pharmacokinetics. Alterations after benserazide, a decarboxylase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

6 June 2018

Reduction of L-type amino acid transporter 1 mRNA expression in brain capillaries in a mouse model of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

18 August 2018

Sequence and significance of dopamine metabolism in the rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

18 August 2018

Blood-brain barrier P-glycoprotein function is not impaired in early Parkinson's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

18 August 2018

The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK-PD experiments.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

18 August 2018

Dopamine turnover is upregulated in the caudate/putamen of asymptomatic MPTP-treated rhesus monkeys

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

18 August 2018

6-Hydroxydopamine-induced alterations in blood-brain barrier permeability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

18 August 2018

Ionic composition of microdialysis perfusing solution alters the pharmacological responsiveness and basal outflow of striatal dopamine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298802

18 August 2018

Increased caudate dopamine turnover may contribute to the recovery of motor function in marmosets treated with the dopaminergic neurotoxin MPTP

1 reference

https://pubmed.ncbi.nlm.nih.gov/22316420

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Striatal L-dopa metabolism studied in vivo in rats with nigrostriatal lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22316420

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of plasma levels of large neutral amino acids and degree of parkinsonism on the blood-to-brain transport of levodopa in naive and MPTP parkinsonian monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/22316420

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of conjugated monoamine metabolites in brain tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/22316420

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microdialysis for pharmacokinetic analysis of drug transport to the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/22316420

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

6-fluoroDOPA metabolism in rat striatum: time course of extracellular metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/22316420

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic and pharmacodynamic studies of L-dopa in rats. II. Effect of L-dopa on dopamine and dopamine metabolite concentration in rat striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/22316420

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/22316420

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic and pharmacodynamic studies of L-dopa in rats. I. Pharmacokinetic analysis of L-dopa in rat plasma and striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/22316420

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1186/2045-8118-9-4

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22316420%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

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22 January 2020

PubMed publication ID

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Europe PubMed Central

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22 January 2020

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