(Q41821426)

12 October 2017

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence (English)

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12 October 2017

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U Weyemi

1

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12 October 2017

O Lagente-Chevallier

2

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12 October 2017

M Boufraqech

3

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12 October 2017

F Prenois

4

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12 October 2017

F Courtin

5

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12 October 2017

B Caillou

6

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12 October 2017

M Talbot

7

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12 October 2017

M Dardalhon

8

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12 October 2017

A Al Ghuzlan

9

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12 October 2017

J-M Bidart

10

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12 October 2017

M Schlumberger

11

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12 October 2017

C Dupuy

12

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12 October 2017

language of work or name

English

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publication date

15 August 2011

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12 October 2017

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12 October 2017

31

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12 October 2017

1117-1129

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12 October 2017

9

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https://scigraph.springernature.com/pub.10.1038/onc.2011.327

12 October 2017

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cites work

Intracellular expression of reactive oxygen species-generating NADPH oxidase NOX4 in normal and cancer thyroid tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

The NADPH oxidase Nox4 restricts the replicative lifespan of human endothelial cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

The Epstein-Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Positive regulation of the NADPH oxidase NOX4 promoter in vascular smooth muscle cells by E2F.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Oncogenes and senescence: breaking down in the fast lane

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Putting the Oncogenic and Tumor Suppressive Activities of E2F into Context

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Tissue distribution and putative physiological function of NOX family NADPH oxidases.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

A DNA damage checkpoint response in telomere-initiated senescence

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Molecular pathobiology of thyroid neoplasms

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Identification of renox, an NAD(P)H oxidase in kidney

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Presence of mutations in all three ras genes in human thyroid tumors

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

NADPH oxidases 1 and 4 mediate cellular senescence induced by resveratrol in human endothelial cells.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Nox4 and nox2 NADPH oxidases mediate distinct cellular redox signaling responses to agonist stimulation

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Overexpression of human NOX1 complex induces genome instability in mammalian cells.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Ras induces chromosome instability and abrogation of the DNA damage response.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Low levels of clustered oxidative DNA damage induced at low and high LET irradiation in mammalian cells.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Rac1 GTPase regulates cell genomic stability and senescence.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

The power and the promise of oncogene-induced senescence markers.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307059

Genetically encoded fluorescent indicator for intracellular hydrogen peroxide

18 August 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.327

Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.327

Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.327

Oncogene activation in melanocytes links reactive oxygen to multinucleated phenotype and senescence

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.327

Complex engagement of DNA damage response pathways in human cancer and in lung tumor progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.327

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.327

31 March 2020

Identifiers

DOI

10.1038/ONC.2011.327

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Dimensions Publication ID

12 October 2017

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12 October 2017

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