(Q41824446)

English

Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.

scientific article published on 19 September 2008

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18805792%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5 (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18805792%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Colin J Henderson

6

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14 January 2020

7

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14 January 2020

Lesley A McLaughlin

2

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Lesley A McLaughlin

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14 January 2020

4

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Ian Rosewell

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14 January 2020

Sebastien Ronseaux

3

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Sebastien Ronseaux

1 reference

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14 January 2020

author name string

Robert D Finn

1

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14 January 2020

J Brian Houston

5

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14 January 2020

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publication date

19 September 2008

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14 January 2020

Journal of Biological Chemistry

1 reference

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14 January 2020

283

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14 January 2020

46

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Europe PubMed Central

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14 January 2020

31385-31393

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18805792%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

6 June 2018

Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

6 June 2018

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

6 June 2018

The many roles of cytochrome b5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

6 June 2018

The roles of cytochrome b5 in cytochrome P450 reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

6 June 2018

Probing the differences between rat liver outer mitochondrial membrane cytochrome b5 and microsomal cytochromes b5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

6 June 2018

Allosteric phenomena in cytochrome P450-catalyzed monooxygenations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

6 June 2018

The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1

1 reference

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6 June 2018

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

6 June 2018

Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

6 June 2018

Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

6 June 2018

Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4. Characterization of a reconstituted cytochrome P450 3A4/NADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

6 June 2018

Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochromes P4501A2 and 2B, respectively, in the rat and mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

6 June 2018

Dissection of NADPH-cytochrome P450 oxidoreductase into distinct functional domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

6 June 2018

Regulation of phenobarbital-inducible cytochrome P-450s in rat and mouse liver following dexamethasone administration and hypophysectomy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

6 June 2018

Cytochrome b5 potentiation of cytochrome P-450 catalytic activity demonstrated by a vaccinia virus-mediated in situ reconstitution system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

6 June 2018

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

6 June 2018

7 Purification and properties of NADPH-Cytochrome P-450 reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

6 June 2018

Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

18 August 2018

Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

18 August 2018

Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

18 August 2018

CYP2C44, a new murine CYP2C that metabolizes arachidonic acid to unique stereospecific products.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

18 August 2018

Mammalian mitochondrial and microsomal cytochromes b(5) exhibit divergent structural and biophysical characteristics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

18 August 2018

Determination of the Rate of Reduction of Oxyferrous Cytochrome P450 2B4 by 5-Deazariboflavin Adenine Dinucleotide T491V Cytochrome P450 Reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

18 August 2018

Expression and Activity of Cytochromes P450 2E1, 2A, and 2B in the Mouse Ovary: The Effect of 4-Vinylcyclohexene and Its Diepoxide Metabolite

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

18 August 2018

Cytochrome b5 reductase and cytochrome b5 support the CYP2E1-mediated activation of nitrosamines in a recombinant Ames test

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

18 August 2018

Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

18 August 2018

The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

18 August 2018

Cytochrome b(5) coexpression increases the CYP2E1-dependent mutagenicity of dialkylnitrosamines in methyltransferase-deficient strains of Salmonella typhimurium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

18 August 2018

Stimulation of cytochrome P450 reactions by apo-cytochrome b5: evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

18 August 2018

The kinetic and spectral characterization of the E. coli-expressed mammalian CYP4A7: cytochrome b5 effects vary with substrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

18 August 2018

Interaction of apo-cytochrome b5 with cytochromes P4503A4 and P45017A: relevance of heme transfer reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

18 August 2018

Effects of benzyl isothiocyanate on rat and human cytochromes P450: identification of metabolites formed by P450 2B1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

18 August 2018

Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms.

1 reference

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18 August 2018

Selective deficiency of debrisoquine 4-hydroxylase activity in mouse liver microsomes.

1 reference

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18 August 2018

A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: expression of CYP3A4, CYP2A6, and CYP2E1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2581580

18 August 2018

Effects of human cytochrome b5 on CYP3A4 activity and stability in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18805792

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Approach to predict the contribution of cytochrome P450 enzymes to drug metabolism in the early drug-discovery stage: the effect of the expression of cytochrome b(5) with recombinant P450 enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18805792

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome b5 increases the rate of product formation by cytochrome P450 2B4 and competes with cytochrome P450 reductase for a binding site on cytochrome P450 2B4

1 reference

https://pubmed.ncbi.nlm.nih.gov/18805792

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome b5 inhibits electron transfer from NADPH-cytochrome P450 reductase to ferric cytochrome P450 2B4

1 reference

https://pubmed.ncbi.nlm.nih.gov/18805792

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for the participation of cytochrome b 5 in hepatic microsomal mixed-function oxidation reactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18805792

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 IIIA1 (P450p) requires cytochrome b5 and phospholipid with unsaturated fatty acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/18805792

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/18805792

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of cytochrome b5, NADPH-P450 reductase, and lipid on the rate of 6 beta-hydroxylation of testosterone as catalyzed by a human P450 3A4 fusion protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/18805792

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome b5, its functions, structure and membrane topology

1 reference

https://pubmed.ncbi.nlm.nih.gov/18805792

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of cytochrome b5 in NADH-dependent microsomal reduction of ferric complexes, lipid peroxidation, and hydrogen peroxide generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18805792

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18805792

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species

1 reference

https://pubmed.ncbi.nlm.nih.gov/18805792

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional co-expression of CYP2D6 and human NADPH-cytochrome P450 reductase in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/18805792

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M803496200

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18805792%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18805792%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18805792%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

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