(Q41856924)

13 October 2017

Development of clickable active site-directed photoaffinity probes for γ-secretase (English)

1 reference

13 October 2017

Christina J Crump

1

1 reference

13 October 2017

Christopher W am Ende

2

1 reference

13 October 2017

T Eric Ballard

3

1 reference

13 October 2017

Nikolay Pozdnyakov

4

1 reference

13 October 2017

Martin Pettersson

5

1 reference

13 October 2017

De-Ming Chau

6

1 reference

13 October 2017

Kelly R Bales

7

1 reference

13 October 2017

Yue-Ming Li

8

1 reference

13 October 2017

Douglas S Johnson

9

1 reference

13 October 2017

language of work or name

English

0 references

publication date

20 February 2012

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13 October 2017

4

1 reference

Bioorganic & Medicinal Chemistry Letters

inferred from page(s)

published in

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13 October 2017

22

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13 October 2017

8

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13 October 2017

2997-3000

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Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1.

13 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Target of γ-secretase modulators, presenilin marks the spot

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Photoaffinity labeling in activity-based protein profiling

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

The many substrates of presenilin/γ-secretase

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Novel research horizons for presenilins and γ-secretases in cell biology and disease

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Modulation of gamma-secretase specificity using small molecule allosteric inhibitors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

An exo-cell assay for examining real-time gamma-secretase activity and inhibition

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Toward structural elucidation of the gamma-secretase complex

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Presenilin: running with scissors in the membrane

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Activity-based probes for proteomic profiling of histone deacetylase complexes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Proteomic profiling of metalloprotease activities with cocktails of active-site probes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Identification of signal peptide peptidase, a presenilin-type aspartic protease

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Small molecule probes that target Abl kinase

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Stereoselective synthesis of photoreactive peptidomimetic gamma-secretase inhibitors

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

gamma-Secretase: characterization and implication for Alzheimer disease therapy

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321063

“Click” Chemistry by Microcontact Printing

2 December 2018

1 reference

12 December 2020

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

12 December 2020

Unraveling the protein targets of vancomycin in living S. aureus and E. faecalis cells

1 reference

12 December 2020

A New Chemical Probe for Proteomics of Carbohydrate-Binding Proteins

1 reference

12 December 2020

10.1016/J.BMCL.2012.02.027

Identifiers

DOI

1 reference

13 October 2017

1 reference

13 October 2017

PubMed publication ID

22418280

1 reference