(Q41867513)

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3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.

scientific article published on 15 November 2013

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1 March 2020

3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant (English)

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1 March 2020

Marta Barniol-Xicota

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1 March 2020

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1 March 2020

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1 March 2020

Santiago Vazquez

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1 March 2020

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Robert A Lamb

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1 March 2020

Lawrence H Pinto

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Lawrence H Pinto

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1 March 2020

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Matias Rey-Carrizo

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1 March 2020

Eva Torres

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1 March 2020

Chunlong Ma

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1 March 2020

Yibing Wu

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1 March 2020

William F DeGrado

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1 March 2020

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15 November 2013

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1 March 2020

Journal of Medicinal Chemistry

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1 March 2020

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1 March 2020

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1 March 2020

9265-9274

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1 March 2020

Synthesis and Anti-influenza A Virus Activity of 2,2-Dialkylamantadines and Related Compounds.

1 reference

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5 June 2018

Mutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonuclease

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Emerging antiviral strategies to interfere with influenza virus entry

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5 June 2018

Role of the viral hemagglutinin in the anti-influenza virus activity of newly synthesized polycyclic amine compounds.

1 reference

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5 June 2018

Drug-induced conformational and dynamical changes of the S31N mutant of the influenza M2 proton channel investigated by solid-state NMR.

1 reference

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5 June 2018

Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus

1 reference

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5 June 2018

Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus

1 reference

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5 June 2018

Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel

1 reference

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5 June 2018

Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2.

1 reference

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5 June 2018

Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus

1 reference

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5 June 2018

Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy

1 reference

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5 June 2018

Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel

1 reference

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5 June 2018

Novel inhibitors of influenza virus fusion: structure-activity relationship and interaction with the viral hemagglutinin

1 reference

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5 June 2018

Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel

1 reference

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5 June 2018

Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus

1 reference

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5 June 2018

Large-scale sequence analysis of M gene of influenza A viruses from different species: mechanisms for emergence and spread of amantadine resistance.

1 reference

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Global transmission of oseltamivir-resistant influenza

1 reference

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5 June 2018

Anti-influenza virus activity and structure-activity relationship of aglycoristocetin derivatives with cyclobutenedione carrying hydrophobic chains.

1 reference

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5 June 2018

Identification of the pore-lining residues of the BM2 ion channel protein of influenza B virus

1 reference

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5 June 2018

Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2007.

1 reference

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5 June 2018

Influenza a virus M2 ion channel activity is essential for efficient replication in tissue culture

1 reference

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5 June 2018

Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block

1 reference

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Sequences of mRNAs derived from genome RNA segment 7 of influenza virus: colinear and interrupted mRNAs code for overlapping proteins

1 reference

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5 June 2018

Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface

1 reference

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Solubilization of matrix protein M1/M from virions occurs at different pH for orthomyxo- and paramyxoviruses

1 reference

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Maturation of influenza A virus hemagglutinin--estimates of the pH encountered during transport and its regulation by the M2 protein

1 reference

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5 June 2018

Structural comparison of the wild-type and drug-resistant mutants of the influenza A M2 proton channel by molecular dynamics simulations

1 reference

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18 August 2018

Emergence of oseltamivir-resistant pandemic H1N1 virus during prophylaxis

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1 reference

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18 August 2018

Comparisons of the influenza virus A M2 channel binding affinities, anti-influenza virus potencies and NMDA antagonistic activities of 2-alkyl-2-aminoadamantanes and analogues

1 reference

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18 August 2018

Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United States

1 reference

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1 reference

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18 August 2018

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10.1021/JM401340P

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1 March 2020

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