(Q41872301)

English

Dihydrobetulinic acid induces apoptosis in Leishmania donovani by targeting DNA topoisomerase I and II: implications in antileishmanial therapy.

scientific article published on January 2003

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12765337%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Dihydrobetulinic acid induces apoptosis in Leishmania donovani by targeting DNA topoisomerase I and II: implications in antileishmanial therapy (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12765337%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

dihydrobetulinic acid

1 reference

ChEBI release 2020-05-28

Leishmania donovani

object named as

Leishmania donovani

1 reference

based on heuristic

inferred from title

author name string

Arnab Roy Chowdhury

1

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Europe PubMed Central

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3 November 2019

Suparna Mandal

2

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3 November 2019

Anindya Goswami

3

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3 November 2019

Monidipa Ghosh

4

1 reference

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3 November 2019

Labanya Mandal

5

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3 November 2019

Debabani Chakraborty

6

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3 November 2019

Agneyo Ganguly

7

1 reference

Europe PubMed Central

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3 November 2019

Gayatri Tripathi

8

1 reference

Europe PubMed Central

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3 November 2019

Sibabrata Mukhopadhyay

9

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3 November 2019

Santu Bandyopadhyay

10

1 reference

Europe PubMed Central

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3 November 2019

Hemanta K Majumder

11

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3 November 2019

language of work or name

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publication date

1 January 2003

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3 November 2019

Molecular Medicine

1 reference

Europe PubMed Central

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3 November 2019

9

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3 November 2019

1-2

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3 November 2019

26-36

1 reference

Europe PubMed Central

PMC publication ID

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3 November 2019

Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

Signal transduction pathways leading to cell cycle arrest and apoptosis induced by DNA topoisomerase poisons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

In vitro and in vivo Leishmanicidal activity of 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIalpha.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

Experimental evaluation of second-line oral treatments of visceral leishmaniasis caused by Leishmania infantum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

Trial of oral miltefosine for visceral leishmaniasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

Activity of oral atovaquone alone and in combination with antimony in experimental visceral leishmaniasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

DNA topoisomerases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

Antileishmanial activity of the ether phospholipid ilmofosine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

Evidence for intercalation of chloroquine into DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

A high affinity topoisomerase I binding sequence is clustered at DNAase I hypersensitive sites in Tetrahymena R-chromatin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

A consensus sequence for cleavage by vertebrate DNA topoisomerase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

DNA topoisomerase poisons as antitumor drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

5 June 2018

Programmed cell death in the unicellular protozoan parasite Leishmania

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

18 August 2018

Phase 2 trial of WR6026, an orally administered 8-aminoquinoline, in the treatment of visceral leishmaniasis caused by Leishmania chagasi.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

18 August 2018

Activation of nuclear factor kappaB through the IKK complex by the topoisomerase poisons SN38 and doxorubicin: a brake to apoptosis in HeLa human carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

18 August 2018

The anti-leishmanial effect of Kalanchoe is mediated by nitric oxide intermediates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

18 August 2018

Drug-promoted cleavage of kinetoplast DNA minicircles. Evidence for type II topoisomerase activity in trypanosome mitochondria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430381

18 August 2018

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

1 reference

https://pubmed.ncbi.nlm.nih.gov/12765337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Medicinal plants in the fight against leishmaniasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12765337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual inhibition of DNA topoisomerases of Leishmania donovani by novel indolyl quinolines

1 reference

https://pubmed.ncbi.nlm.nih.gov/12765337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decatenation of kinetoplast DNA by an ATP-dependent DNA topoisomerase from the kinetoplast hemoflagellate Leishmania donovani

1 reference

https://pubmed.ncbi.nlm.nih.gov/12765337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of itraconazole in the treatment of mucocutaneous leishmaniasis: a pilot study

1 reference

https://pubmed.ncbi.nlm.nih.gov/12765337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of bulk and c-myc P2 promoter-specific DNA damage by an anti-topoisomerase II agent salvicine is an early event leading to apoptosis in HL-60 cells

1 reference

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12 December 2020

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Intracellular development of choleraphage phi 149 under permissive and nonpermissive conditions: an electron microscopic study

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Leishmania donovani: oral efficacy and toxicity of formycin B in the infected hamster

1 reference

https://pubmed.ncbi.nlm.nih.gov/12765337

12 December 2020

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inferred from PubMed ID database lookup

NF-κB Activation Is a Critical Regulator of Human Granulocyte Apoptosisin Vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/12765337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diospyrin, a bisnaphthoquinone: a novel inhibitor of type I DNA topoisomerase of Leishmania donovani

1 reference

https://pubmed.ncbi.nlm.nih.gov/12765337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple procedure for the preparation of pure kinetoplast DNA network free of nuclear DNA from the kinetoplast hemoflagellate Leishmania donovani

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Differential actions of aclarubicin and doxorubicin: the role of topoisomerase I

1 reference

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based on heuristic

inferred from PubMed ID database lookup

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12765337%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12765337%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

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