(Q41876173)

English

Kaposi's sarcoma associated herpesvirus tegument protein ORF75 is essential for viral lytic replication and plays a critical role in the antagonization of ND10-instituted intrinsic immunity.

scientific article published on 16 January 2014

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scholarly article

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6 March 2020

Kaposi's sarcoma associated herpesvirus tegument protein ORF75 is essential for viral lytic replication and plays a critical role in the antagonization of ND10-instituted intrinsic immunity (English)

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6 March 2020

Kaposi's sarcoma

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Michael Stürzl

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6 March 2020

Thomas Stamminger

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Thomas Stamminger

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Armin Ensser

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6 March 2020

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Florian Full

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Doris Jungnickl

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Nina Reuter

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6 March 2020

Kevin Brulois

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Brigitte Scholz

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6 March 2020

Jinjong Myoung

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Jae U Jung

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6 March 2020

publication date

16 January 2014

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6 March 2020

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6 March 2020

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6 March 2020

1

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6 March 2020

e1003863

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6 March 2020

copyright license

Creative Commons Attribution 4.0 International

16 January 2014

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11 June 2022

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based on heuristic

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Kaposi's sarcoma-derived cell line SLK is not of endothelial origin, but is a contaminant from a known renal carcinoma cell line

1 reference

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Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 3 inhibits gamma interferon and major histocompatibility complex class II expression

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Covalent modification by SUMO is required for efficient disruption of PML oncogenic domains by Kaposi's sarcoma-associated herpesvirus latent protein LANA2.

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The epigenetic landscape of latent Kaposi sarcoma-associated herpesvirus genomes.

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KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine

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Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a SUMO E3 ligase that is SIM-dependent and SUMO-2/3-specific

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Kaposi's sarcoma-associated herpesvirus protein LANA2 disrupts PML oncogenic domains and inhibits PML-mediated transcriptional repression of the survivin gene

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New insights into the role of the subnuclear structure ND10 for viral infection

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Multiple functions for ORF75c in murid herpesvirus-4 infection

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Murine gammaherpesvirus 68 open reading frame 75c tegument protein induces the degradation of PML and is essential for production of infectious virus

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Virion-wide protein interactions of Kaposi's sarcoma-associated herpesvirus

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Inhibition of interferon regulatory factor 7 (IRF7)-mediated interferon signal transduction by the Kaposi's sarcoma-associated herpesvirus viral IRF homolog vIRF3.

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Evidence for a role of the cellular ND10 protein PML in mediating intrinsic immunity against human cytomegalovirus infections

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Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expression

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Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis.

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Identifiers

10.1371/JOURNAL.PPAT.1003863

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Europe PubMed Central

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6 March 2020

1 reference

Europe PubMed Central

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6 March 2020

1 reference

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6 March 2020

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