(Q41880723)

13 October 2017

Arrest of myelination and reduced axon growth when Schwann cells lack mTOR. (English)

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13 October 2017

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5

Klaus-Armin Nave

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13 October 2017

Yann-Gaël Gangloff

6

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author name string

Diane L Sherman

1

1 reference

13 October 2017

Michiel Krols

2

1 reference

13 October 2017

Lai-Man N Wu

3

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13 October 2017

Matthew Grove

4

1 reference

13 October 2017

Peter J Brophy

7

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13 October 2017

language of work or name

English

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publication date

1 February 2012

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13 October 2017

Journal of Neuroscience

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13 October 2017

32

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13 October 2017

5

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13 October 2017

1817-1825

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describes a project that uses

13 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4298696/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Proteomic identification of novel targets regulated by the mammalian target of rapamycin pathway during oligodendrocyte differentiation

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mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway

5 June 2018

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An emerging role for TOR signaling in mammalian tissue and stem cell physiology

5 June 2018

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Schwann cell mitochondrial metabolism supports long-term axonal survival and peripheral nerve function

5 June 2018

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N-WASp is required for Schwann cell cytoskeletal dynamics, normal myelin gene expression and peripheral nerve myelination.

5 June 2018

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Axonally derived neuregulin-1 is required for remyelination and regeneration after nerve injury in adulthood.

5 June 2018

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N-WASP is required for membrane wrapping and myelination by Schwann cells

5 June 2018

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Rheb1 is required for mTORC1 and myelination in postnatal brain development

5 June 2018

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mTOR: from growth signal integration to cancer, diabetes and ageing

5 June 2018

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Nrg1/ErbB signaling networks in Schwann cell development and myelination

5 June 2018

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Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice

5 June 2018

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MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

5 June 2018

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Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination.

5 June 2018

1 reference

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Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination

5 June 2018

1 reference

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Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

5 June 2018

1 reference

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Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination.

5 June 2018

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Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation

5 June 2018

1 reference

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

5 June 2018

1 reference

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Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

5 June 2018

1 reference

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

5 June 2018

1 reference

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Constitutively active Akt induces enhanced myelination in the CNS

5 June 2018

1 reference

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Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function

5 June 2018

1 reference

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Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival

5 June 2018

1 reference

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FAK is required for axonal sorting by Schwann cells

5 June 2018

1 reference

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Axonal regulation of myelination by neuregulin 1.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

TOR signaling in growth and metabolism

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Neurofascins are required to establish axonal domains for saltatory conduction

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Mechanisms of axon ensheathment and myelin growth

5 June 2018

1 reference

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The origin and development of glial cells in peripheral nerves

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Restricted growth of Schwann cells lacking Cajal bands slows conduction in myelinated nerves.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Axonal neuregulin-1 regulates myelin sheath thickness

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

The effect of myelinating Schwann cells on axons.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Loss of distal axons and sensory Merkel cells and features indicative of muscle denervation in hindlimbs of P0-deficient mice

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Requirement of heavy neurofilament subunit in the development of axons with large calibers

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Severe neuropathies in mice with targeted mutations in the ErbB3 receptor

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Krox-20 controls myelination in the peripheral nervous system

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Axon-induced mitogenesis of human Schwann cells involves heregulin and p185erbB2.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Changes in DNA synthesis rate in the Schwann cell lineage in vivo are correlated with the precursor--Schwann cell transition and myelination

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Studies of Schwann cell proliferation. II. Characterization of the stimulation and specificity of the response to a neurite membrane fraction.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Presence of the myelin-associated glycoprotein correlates with alterations in the periodicity of peripheral myelin

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

The relationships between interphase Schwann cells and axons before myelination: A quantitative electron microscopic study

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Evidence that sensory axons are mitogenic for Schwann cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

IGF-1-stimulated protein synthesis in oligodendrocyte progenitors requires PI3K/mTOR/Akt and MEK/ERK pathways.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

The axis of mTOR-mitochondria-ROS and stemness of the hematopoietic stem cells

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Neuregulin signaling through a PI3K/Akt/Bad pathway in Schwann cell survival

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298696

Axonal regulation of Schwann cell proliferation and survival and the initial events of myelination requires PI 3-kinase activity

18 August 2018

1 reference

12 December 2020

Lipid composition of myelin from the peripheral nervous system. Intradural spinal roots

1 reference

12 December 2020

Mitotic Schwann cells in developing nerve: Their changes in shape, fine structure, and axon relationships

1 reference

12 December 2020

Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells

1 reference

12 December 2020

Modulation of axon diameter and neurofilaments by hypomyelinating Schwann cells in transgenic mice

1 reference

12 December 2020

Altered neurofilament phosphorylation and beta tubulin isotypes in Charcot-Marie-Tooth disease type 1

1 reference

12 December 2020

Modulation of the axonal microtubule cytoskeleton by myelinating Schwann cells

1 reference

12 December 2020

Abnormal Schwann cell/axon interactions in the Trembler-J mouse

1 reference

12 December 2020

Formation of compact myelin is required for maturation of the axonal cytoskeleton

1 reference

12 December 2020

The relationship between axons and Schwann cells during development of peripheral nerves in the rat

1 reference

12 December 2020

10.1523/JNEUROSCI.4814-11.2012

Identifiers

DOI

1 reference

13 October 2017

1 reference

13 October 2017

PubMed publication ID

22302821

1 reference