(Q41881169)

13 October 2017

The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain (English)

1 reference

13 October 2017

Renate Lüllmann-Rauch

4

object named as

Renate Lüllmann-Rauch

0 references

Regina Fluhrer

10

object named as

Regina Fluhrer

1 reference

13 October 2017

Ralf Dressel

2

0 references

Eeva-Liisa Eskelinen

object named as

Eeva-Liisa Eskelinen

8

0 references

author name string

Janna Schneppenheim

1

1 reference

13 October 2017

Susann Hüttl

3

1 reference

13 October 2017

Renate Lüllmann-Rauch

4

1 reference

13 October 2017

Michael Engelke

5

1 reference

13 October 2017

Kai Dittmann

6

1 reference

13 October 2017

Jürgen Wienands

7

1 reference

13 October 2017

Irm Hermans-Borgmeyer

9

1 reference

13 October 2017

Paul Saftig

11

1 reference

13 October 2017

Bernd Schröder

12

1 reference

13 October 2017

language of work or name

English

0 references

publication date

24 December 2012

1 reference

Journal of Experimental Medicine

13 October 2017

1 reference

13 October 2017

210

1 reference

13 October 2017

1

1 reference

13 October 2017

41-58

1 reference

B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.

13 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Soluble BAFF levels inversely correlate with peripheral B cell numbers and the expression of BAFF receptors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Towards a systems understanding of MHC class I and MHC class II antigen presentation.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Invariant chain increases the half-life of MHC II by delaying endosomal maturation.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

B-cell targeted therapies in human autoimmune diseases: an updated perspective

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

B cell receptor and BAFF receptor signaling regulation of B cell homeostasis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

MHC II and the endocytic pathway: regulation by invariant chain.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

B-cell-directed therapies for autoimmune disease

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Intramembrane proteolysis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Ca(2+) signaling in antigen receptor-activated B lymphocytes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

CD74 is a member of the regulated intramembrane proteolysis-processed protein family

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

B-lymphocytes, innate immunity, and autoimmunity

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Intramembrane proteolysis: theme and variations.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Invariant chain, a chain of command

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

The cytoplasmic tail of invariant chain modulates antigen processing and presentation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Intramembrane proteolysis controls diverse signalling pathways throughout evolution

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

The cytoplasmic tail of invariant chain regulates endosome fusion and morphology

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Invariant chain induces B cell maturation in a process that is independent of its chaperonic activity

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Uncoating ATPase Hsc70 is recruited by invariant chain and controls the size of endocytic compartments

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Invariant chain induces B cell maturation by activating a TAF(II)105-NF-kappaB-dependent transcription program

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Mice lacking all conventional MHC class II genes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

Requirement for invariant chain in B cell maturation and function.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549707

An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

18 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20121069

Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20121069

The transmembrane segment of invariant chain mediates binding to MHC class II molecules in a CLIP-independent manner

21 January 2018

1 reference

12 December 2020

Regulation of the T-independent humoral response by TACI

1 reference

12 December 2020

Activation and accumulation of B cells in TACI-deficient mice

1 reference

12 December 2020

Invariant chain-induced B cell differentiation requires intramembrane proteolytic release of the cytosolic domain

1 reference

12 December 2020

Mice deficient in invariant-chain and MHC class II exhibit a normal mature B2 cell compartment

1 reference

12 December 2020

Selective modulation of the major histocompatibility complex class II antigen presentation pathway following B cell receptor ligation and protein kinase C activation

1 reference

12 December 2020

Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice

1 reference

12 December 2020

In vivo control of endosomal architecture by class II-associated invariant chain and cathepsin S

1 reference

12 December 2020

CD74 induces TAp63 expression leading to B-cell survival

1 reference

12 December 2020

Toxic MHC class II beta chains

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20121069

1 reference

13 October 2017

1 reference

13 October 2017

PubMed publication ID

23267015

1 reference