(Q41887103)

English

Thermodynamic stability and Watson-Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect.

scientific article published on 6 November 2008

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scholarly article

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25 December 2019

Thermodynamic stability and Watson-Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect (English)

1 reference

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25 December 2019

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25 December 2019

author name string

Kumiko Ui-Tei

1

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25 December 2019

Kenji Nishi

3

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25 December 2019

Aya Juni

4

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25 December 2019

Kaoru Saigo

5

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25 December 2019

publication date

6 November 2008

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25 December 2019

Nucleic Acids Research

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25 December 2019

36

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25 December 2019

7100-7109

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25 December 2019

22

1 reference

Europe PubMed Central

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25 December 2019

MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation

1 reference

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5 June 2018

miR-148 targets human DNMT3b protein coding region

1 reference

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5 June 2018

Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

miRBase: tools for microRNA genomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

MicroRNA targeting specificity in mammals: determinants beyond seed pairing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

siRNA-mediated off-target gene silencing triggered by a 7 nt complementation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage

1 reference

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5 June 2018

RNAi: the nuts and bolts of the RISC machine

1 reference

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5 June 2018

Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

MicroRNAs: genomics, biogenesis, mechanism, and function

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

https://api.crossref.org/works/10.1093%2FNAR%2FGKN902

21 January 2018

Functional siRNAs and miRNAs Exhibit Strand Bias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

Asymmetry in the assembly of the RNAi enzyme complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

Expression profiling reveals off-target gene regulation by RNAi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

The G x U wobble base pair. A fundamental building block of RNA structure crucial to RNA function in diverse biological systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

Thermodynamics of base pairing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

Improved free-energy parameters for predictions of RNA duplex stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

5 June 2018

Comparison of different melting temperature calculation methods for short DNA sequences.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

18 August 2018

Robust estimators for expression analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

18 August 2018

Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602766

18 August 2018

Identifiers

10.1093/NAR/GKN902

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18988625%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18988625%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18988625%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

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