(Q41897802)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25184038%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

title

Metformin directly acts on mitochondria to alter cellular bioenergetics (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25184038%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25184038%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

author name string

Sylvia Andrzejewski

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25184038%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Michael Pollak

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25184038%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Julie St-Pierre

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25184038%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

publication date

28 August 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25184038%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25184038%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

volume

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25184038%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

page(s)

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25184038%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1186/2049-3002-2-12

15 February 2020

exact match

0 references

cites work

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1 reference

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5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

5 June 2018

1 reference

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5 June 2018

1 reference

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5 June 2018

1 reference

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5 June 2018

1 reference

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Respiratory complex I is essential to induce a Warburg profile in mitochondria-defective tumor cells

5 June 2018

1 reference

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Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler

5 June 2018

1 reference

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Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch.

5 June 2018

1 reference

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5 June 2018

1 reference

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Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells.

5 June 2018

1 reference

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Physical and functional association of lactate dehydrogenase (LDH) with skeletal muscle mitochondria

5 June 2018

1 reference

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Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF.

5 June 2018

1 reference

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PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.

5 June 2018

1 reference

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Carbon source and myc expression influence the antiproliferative actions of metformin

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Investigating metformin for cancer prevention and treatment: the end of the beginning

5 June 2018

1 reference

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Genetically-defined metabolic reprogramming in cancer

5 June 2018

1 reference

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Cellular responses to the metal-binding properties of metformin.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

PGC-1α promotes the growth of ErbB2/Neu-induced mammary tumors by regulating nutrient supply

5 June 2018

1 reference

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Reductive carboxylation supports growth in tumour cells with defective mitochondria.

5 June 2018

1 reference

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PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis.

5 June 2018

1 reference

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2,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity and risk of death

5 June 2018

1 reference

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5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Metformin activates AMP kinase through inhibition of AMP deaminase

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Transcriptional control of the ERBB2 amplicon by ERRalpha and PGC-1beta promotes mammary gland tumorigenesis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling

5 June 2018

1 reference

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Metformin--the gold standard in type 2 diabetes: what does the evidence tell us?

5 June 2018

1 reference

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The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Elevated expression of DecR1 impairs ErbB2/Neu-induced mammary tumor development

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Mitochondriotoxic compounds for cancer therapy

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Drug specificity and intestinal membrane localization of human organic cation transporters (OCT).

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Metformin and reduced risk of cancer in diabetic patients

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

A study of the action of hypoglycemia-producing biguanide and sulfonylurea compounds on oxidative phosphorylation.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Mechanism by which metformin reduces glucose production in type 2 diabetes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Metformin: a new oral biguanide

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Mitochondrial Membrane Potential in Living Cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Biomolecular mode of action of metformin in relation to its copper binding properties.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

The U.K. Prospective Diabetes Study. A review.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147388

Diabetes and Cancer: A Consensus Report

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25184038

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Impact of PGC-1α on the topology and rate of superoxide production by the mitochondrial electron transport chain

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25184038

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/2049-3002-2-12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25184038%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

15 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25184038%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25184038%20AND%20SRC:MED&resulttype=core&format=json